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227
datasets available to search
ShareScore release 0.7.1
Dataset results
227 results for “CVD”
Prospective Analysis of the Effect of Widowhood on CVD
ClinicalTrials.gov study NCT00005424. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Visceral Adiposity and CVD Risk in Women
ClinicalTrials.gov study NCT00021879. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Genetic Epidemiology of CVD Risk Factors
ClinicalTrials.gov study NCT00053521. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Neighborhoods and CVD Risk in a Multiethnic Cohort - Ancillary to MESA
ClinicalTrials.gov study NCT00063557. IPD Sharing: Not stated. Countries: 0. Publications: 0.
SES, Health Behaviors and CVD Among Vietnam-Era Twins
ClinicalTrials.gov study NCT00081679. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Changes in macrophages and endothelial cells mechanics treated with native LDL from donors with CVD
GEO Series GSE303475. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Data set from the article Vianello E, Dozio E, Bandera F, Schmitz G, Nebuloni M, Longhi E, Tacchini L, Guazzi M, Corsi Romanelli MM. Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression. Sci Rep. 2019 Jul 17;9(1):10331. doi: 10.1038/s41598-019-46676-w. Erratum in: Sci Rep. 2020 Jan 21;10(1):1182. PMID: 31316160; PMCID: PMC6637132.
<p>Data set from the article Vianello E, Dozio E, Bandera F, Schmitz G, Nebuloni M, Longhi E, Tacchini L, Guazzi M, Corsi Romanelli MM. Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression. Sci Rep. 2019 Jul 17;9(1):10331. doi: 10.1038/s41598-019-46676-w. Erratum in: Sci Rep. 2020 Jan 21;10(1):1182. PMID: 31316160; PMCID: PMC6637132.</p> <p>This is the abstract:</p> <p>Dysfunctional epicardial adipose tissue (EAT) secretome can influence the heart's stretch response. However, the molecular mechanisms are still poorly understood. The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production associated with exchange protein directly activated by cAMP (EPAC) proteins. A series of 55 CVD males were enrolled and their EAT thickness, LV mass and volumes were measured by echocardiography. Blood, plasma and EAT biopsies were collected for molecular and proteomic assays. Taking EAT thickness as a continuous variable there was a direct correlation between the ST2 cardiac stretch mediator and EAT thickness (r = 0.54, p < 0.01) and an inverse relation between the ST2 gene and IL-33 expression (r -0.50, p < 0.01). In the CVD population EPAC2 expression directly correlated with the ST2 gene (r = 0.74, p < 0.0001) causing an ST2/IL-33 system local (p < 0.001) and systemic (sST2 = 57.33 ± 3.22 and IL-33 = 0.53 ± 017 pg/mL; p < 0.0001) protein imbalance associated with maladaptive remodeling. This indicated that dysfunctional EAT is a source of both EPAC and ST2 protein and an EPAC2 isoform seems involved in ST2 production in adipose tissue. Both EPAC2 and ST2 expression were directly related to maladaptive heart remodeling indices, suggesting EAT measurements could be useful in the early assessment of CVD complications.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.