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Dataset results
240 results for “Cardiotoxicity”
Carfilzomib Suppresses SENP1 to Trigger Cardiotoxicity by DDX17 Destabilization
GEO Series GSE273971. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Identifying metabolic adaptations of rat cardiomyocytes in response to cardiotoxicity
GEO Series GSE166957. Rattus norvegicus. 65 samples. Type: Expression profiling by high throughput sequencing.
The Cardiac Endothelial Cell cGAS-STING Pathway Promotes Doxorubicin-Induced Cardiotoxicity via CD38-Mediated NAD Decline and Mitochondrial Dysfunction
GEO Series GSE226116. Homo sapiens; Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Activation of the ERRα Transcriptional Pathway Alleviates Anthracycline-induced Cardiotoxicity by Improving Mitochondrial Metabolism
GEO Series GSE291275. Sus scrofa. 8 samples. Type: Expression profiling by high throughput sequencing.
Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs – Model Verification with Doxorubicin
GEO Series GSE242692. Homo sapiens. 88 samples. Type: Expression profiling by high throughput sequencing.
Evaluation and mechanism study of cardiotoxicity caused by antipsychotics using human-induced pluripotent stem cell-derived cardiomyocytes
GEO Series GSE248368. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The Cardiac Endothelial Cell cGAS-STING Pathway Promotes Doxorubicin-Induced Cardiotoxicity via CD38-Mediated NAD Decline and Mitochondrial Dysfunction [mouse]
GEO Series GSE226114. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The Cardiac Endothelial Cell cGAS-STING Pathway Promotes Doxorubicin-Induced Cardiotoxicity via CD38-Mediated NAD Decline and Mitochondrial Dysfunction [human]
GEO Series GSE226115. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Electroacupuncture at PC6 Acupoint Adjusts Genome-Wide Gene Expressions and Alters Carfilzomib-Induced Cardiotoxicity in Mice
GEO Series GSE243878. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Pharmacogenetics and Drug Discovery for Anthracycline-Induced Cardiotoxicity Enabled by Sinoatrial Node-like Cells Derived from Human Pluripotent Stem Cells [SNP array]
GEO Series GSE118086. Homo sapiens. 42 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Cardiotoxicity of tubulin binders
GEO Series GSE19290. Rattus norvegicus. 82 samples. Type: Expression profiling by array.
Effect of Smad3 knockout on doxorubicin cardiotoxity
GEO Series GSE206679. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Activation of the ERRα Transcriptional Pathway Alleviates Anthracycline-induced Cardiotoxicity by Improving Mitochondrial Metabolism
GEO Series GSE291450. Sus scrofa. 9 samples. Type: Expression profiling by high throughput sequencing.
The effects of Baz2b-knockout on doxorubicin-induced cardiotoxicity
GEO Series GSE236165. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of TGFB1 and Smad3 deficiency on doxorubicin cardiotoxity
GEO Series GSE206743. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity.
<p>Monti CB, Schiaffino S, Galimberti Ortiz MDM, Capra D, Zanardo M, De Benedictis E, Luporini AG, Spagnolo P, Secchi F, Sardanelli F. Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity. Insights Imaging. 2021 Nov 6;12(1):161. doi: 10.1186/s13244-021-01069-4. PMID: 34741673; PMCID: PMC8571675.</p> <p><strong>Background: </strong>We investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role of EAT density as a biomarker of changes related to chemotherapy cardiotoxicity.</p> <p><strong>Methods: </strong>We reviewed BC patients treated with anthracyclines who underwent CT before (CT-t<sub>0</sub>) and after (CT-t<sub>1</sub>) chemotherapy, and age- and sex-matched controls who underwent two CT examinations at comparable intervals. On non-contrast scans, EAT was segmented contouring the pericardium and thresholding between -190 and -30 Hounsfield units (HU), and SAT and VAT were segmented with two 15-mm diameter regions of interest thresholded between -195 and -45 HU.</p> <p><strong>Results: </strong>Thirty-two female patients and 32 controls were included. There were no differences in age (p = 0.439) and follow-up duration (p = 0.162) between patients and controls. Between CT-t<sub>0</sub> and CT-t<sub>1</sub>, EAT density decreased in BC patients (-66 HU, interquartile range [IQR] -71 to -63 HU, to -71 HU, IQR -75 to -66 HU, p = 0.003), while it did not vary in controls (p = 0.955). SAT density increased from CT-t<sub>0</sub> to CT-t<sub>1</sub> in BC patients (-107 HU, IQR -111 to -105 HU, to -105 HU, IQR -110 to -100 HU, p = 0.014), whereas it did not change in controls (p = 0.477). VAT density did not vary in either BC patients (p = 0.911) or controls (p = 0.627).</p> <p><strong>Conclusions: </strong>EAT density appears to be influenced by anthracycline treatment for BC, well known for its cardiotoxicity, shifting towards lower values indicative of a less active metabolism.</p>
Development and Psychometric Validation of the Nursing Self-Efficacy Scale for Managing Cancer Treatment-Induced Cardiotoxicity: An Exploratory Mixed-Method Study.
<p>Magon A, Conte G, Arrigoni C, Dellafiore F, de Maria M, Pittella F, Rocco G, Stievano A, Ghizzardi G, Caruso R. Development and Psychometric Validation of the Nursing Self-Efficacy Scale for Managing Cancer Treatment-Induced Cardiotoxicity: An Exploratory Mixed-Method Study. Semin Oncol Nurs. 2022 Nov 18:151367. doi: 10.1016/j.soncn.2022.151367. Epub ahead of print. PMID: 36411124.</p> <p>Abstract</p> <p><strong>Objective: </strong>Assessing nursing self-efficacy could be strategic to sustain nursing competence. This study aimed to develop and validate the nursing self-efficacy scale for managing cancer treatment-induced cardiotoxicity (NSS-CTC).</p> <p><strong>Data sources: </strong>An exploratory mixed-method study was performed by including two main phases. The first comprised the developmental tasks to generate the initial pool of items, including a literature review and a consensus meeting based on a nominal group technique. The second phase initially involved an external panel of experts in assessing the content validity of the novel scale, followed by a cross-sectional data collection to perform exploratory factor analysis by employing a multicenter and convenience sampling approach. The most plausible psychometric structure derived from the exploratory factor analysis was tested with a confirmatory factor analysis using a second data collection round on another sample enrolled with a multicenter and convenience sampling approach. Internal consistency was assessed using Cronbach's alfa.</p> <p><strong>Conclusion: </strong>The NSS-CTS is a novel 15-item self-report measure for assessing nurse self-efficacy in dealing with cancer treatment-related cardiotoxicity. Its two plausible domains were labeled knowledge-related self-efficacy (Cronbach's α = 0.924) and practice-related self-efficacy (Cronbach's α = 0.937); the factor analyses in both samples showed adequate fit to sample statistics. Future studies are necessary to corroborate its construct validity and assess its measurement invariance across various country contexts.</p> <p><strong>Implications for nursing practice: </strong>Assessing nursing self-efficacy for managing cancer treatment-induced cardiotoxicity is a promising approach for identifying educational gaps and promoting nursing competency in this particular area of cancer care.</p>
Noninvasive neuromodulation protects against doxorubicin-induced cardiotoxicity and inhibits tumor growth
GEO Series GSE253959. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Gasdermin D Mediates Endoplasmic Reticulum Stress via FAM134B to Regulate Cardiomyocyte Autophagy and Apoptosis in Doxorubicin-induced Cardiotoxicity
GEO Series GSE213613. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity
GEO Series GSE240959. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.