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236
datasets available to search
ShareScore release 0.9.0
Dataset results
236 results for “Surfactants”
Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep
GEO Series GSE131195. Ovis aries. 24 samples. Type: Expression profiling by high throughput sequencing.
Lung collapse and respiratory distress in neonatal cloned cows is caused by surfactant homeostasis disorders
GEO Series GSE88912. Bos taurus. 8 samples. Type: Expression profiling by array.
RNA-Seq Analysis of the Human Surfactant Air-Liquid Interface Culture Reveals Alveolar Type II Cell-like Transcriptome
GEO Series GSE171624. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Isoleucyl-tRNA synthetase 1 novel mutation promotes deposition of pulmonary surfactant through stabilizing Cathepsin Z
GEO Series GSE250412. Homo sapiens; Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Chemotherapy modulates intestinal immune gene expression in piglets including surfactant protein-D and DMBT1
GEO Series GSE71964. Sus scrofa. 22 samples. Type: Expression profiling by array.
An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection
GEO Series GSE214772. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
Impact of Surfactant's Availability on Newborns
ClinicalTrials.gov study NCT00005432. IPD Sharing: Not stated. Countries: 0. Publications: 0.
An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [Prox, Distal, and Whole
GEO Series GSE214762. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Synergistic enhancement of SvLAC-1 gene expression by strong promoter and surfactant: A novel strategy to improve laccase production in Inocutis levis
GEO Series GSE280815. Inocutis levis. 6 samples. Type: Expression profiling by high throughput sequencing.
Novel Immune Response Evasion Strategy to Redose Adeno-Associated Viral Vectors and Prolong Survival in Surfactant Protein-B Deficient Mice
GEO Series GSE282558. Mus musculus. 33 samples. Type: Expression profiling by array.
Isoleucyl-tRNA synthetase 1 novel mutation promotes deposition of pulmonary surfactant through stabilizing Cathepsin Z [RNA-seq]
GEO Series GSE250270. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Gpr116 regulates pulmonary surfactant pool size
GEO Series GSE41417. Mus musculus. 6 samples. Type: Expression profiling by array.
Effect of topical treatment with either lung surfactant or selective MMP inhibitor on excisional wounds in mice
GEO Series GSE110438. Mus musculus. 36 samples. Type: Expression profiling by array.
Transient expression of misfolded surfactant protein C
GEO Series GSE16054. Homo sapiens. 9 samples. Type: Expression profiling by array.
miRNAs regulate lung development and surfactant homeostasis via directly targeting SFTPC and TTF-1 in reprogramming-derived bovine model of NRDS
GEO Series GSE87861. Bos taurus. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Impact of Sacubitril/Valsartan on surfactant binding protein, central sleep apnea, lung function tests and heart failure biomarkers: hemodynamic or pleiotropism?
<p><strong>Purpose:</strong> Little is known about the mechanism underlying Sacubitril/Valsartan effects in patients with heart failure (HFrEF). Aim of the study is to assess hemodynamic vs. non-hemodynamic Sacubitril/Valsartan effects by analyzing several biological and functional parameters.</p> <p><strong>Methods: </strong>Seventy-nine patients (86% males, age 66±10 years) were enrolled. At baseline and 6 months after reaching the maximum Sacubitril/Valsartan tolerated dose, we assessed biomarkers, transthoracic echocardiography, polysomnography, spirometry, and carbon monoxide diffusing capacity of the lung (DLCO).</p> <p><strong>Results:</strong> Mean follow-up was 261±41 days with 83% of patients reaching Sacubitril/Valsartan maximum dose (97/103mg b.i.d). Significant improvements were observed in cardiac performance and biomarkers: left ventricular ejection fraction increased (31±5 vs. 37±9 %; p<0.001), end-diastolic and end-systolic volumes decreased; NT-proBNP decreased (1196 [IQR 648-2891] vs. 958 [IQR 424-1663] pg/ml; p<0.001) in parallel with interleukin ST-2 (28.4 [IQR 19.4-36.6] vs. 20.4 [IQR 15.1-29.2] ng/ml; p<0.001) and circulating surfactant binding proteins (proSP-B: 58.43 [IQR 40.42-84.23] vs. 50.36 [IQR 37.16-69.54] AU; p=0.014 and SP-D: 102.17 [IQR 62.85-175.34] vs. 77.64 [IQR 53.55-144.70] AU; p<0.001).</p> <p>Forced expiratory volume in 1 second and forced vital capacity improved. DLCO increased in the patients’ subgroup (n=39) with impaired baseline values (from 65.3±10.8 to 70.3±15.9 %predicted; p=0.013). We also observed a significant reduction in central sleep apneas (CSA).</p> <p><strong>Conclusion</strong>: Sacubitril/Valsartan effects share a double pathway: hemodynamic and systemic. The first is evidenced by NT-proBNP, proSP-B, lung mechanics, and CSA improvement. The latter is confirmed by an amelioration of DLCO, ST-2, SP-D as well as by reverse remodeling echocardiographic parameters.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.