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889 results for “fatty liver”
Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT00633282. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Kidney Affection in Non Alcaholic Fatty Liver Diseases
ClinicalTrials.gov study NCT04273230. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)
ClinicalTrials.gov study NCT03350165. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Vitamin E on Non-Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT02690792. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Multiple Ascending Dose Study to Evaluate Safety and Tolerability of BFKB8488A in Participants With Type 2 Diabetes Mellitus and Participants With Non-Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT03060538. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Non Alcoholic Fatty Liver Disease: Nutritional Epidemiology and Lifestyle Medicine
ClinicalTrials.gov study NCT03300661. IPD Sharing: NO. Countries: 1. Publications: 1.
The Influence of SARS-CoV-2 Lifestyle Changes on Non-alcoholic Fatty Liver Disease Evolution
ClinicalTrials.gov study NCT05416970. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver
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Data from: Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins
The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat, isocaloric diets. Animal growth rates and mitochondrial respiratory parameters were essentially unaffected, but mass spectrometry-based, mitochondrial lipidomics profiling revealed increased levels of cardiolipins (CLs), a family of phospholipids essential for mitochondrial structure and function, in rats fed saturated or trans fat-based diets with a high glycemic index. These mitochondria showed elevated monolysocardiolipins (a CL precursor/product of CL degradation), elevated ratio of trans PC (18:1/18:1) to cis PC (18:1/18:1) (a marker of thiyl radical stress), and decreased ubiquinone Q9 -- the latter two of which imply a low-grade mitochondrial redox abnormality. Extended analysis demonstrated: (i) dietary fats and, to a lesser extent, carbohydrates induce changes in the relative abundance of specific CL species; (ii) Fatty acid (FA) incorporation into mature CLs undergoes both positive (>400-fold) and negative (2.5-fold) regulation; and, (iii) dietary lipid abundance and incorporation of FAs into both the CL pool and specific mature tetra-acyl CLs are inversely related, suggesting previously unobserved compensatory regulation. This study reveals previously unobserved complexity/regulation of the central lipid in mitochondrial metabolism.
EFFECTIVENESS OF COMPLEX TREATMENT OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN PSORIATIC ARTHRITIS
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Step Change - CSI 2 – Non-Alcoholic Fatty Liver Disease in the UK – Infographic
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Rodent Model of Non-alcoholic Fatty Liver Disease: A Systematic Review
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Data from: Effects of 4-Hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on liver transcriptome in rats: implication in the disruption of circadian rhythm and fatty acid metabolism
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) have been detected in tissues of both wild animals and humans. Several previous studies have suggested adverse effects of OH-PCBs on the endocrine and nervous systems in mammals. However, there have been no studies on transcriptome analysis of the effects of OH-PCBs, and thus, the whole picture and mechanisms underlying the adverse effects induced by OH-PCBs are still poorly understood. We therefore investigated the mRNA expression profile in the liver of adult male Wistar rats treated with 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) to explore the genes responsive to OH-PCBs and to understand the potential effects of the chemical. Next-generation RNA sequencing analysis revealed changes in the expression of genes involved in the circadian rhythm and fatty acid metabolism, such as nuclear receptor subfamily 1, group D, member 1 (Nr1d1), aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl), cryptochrome circadian clock 1 (Cry1), and enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase (Ehhadh), in 4-OH-CB107-treated rats. In addition, biochemical analysis of the plasma revealed a dose-dependent increase in the leucine aminopeptidase (LAP), indicating the onset of liver damage. These results suggest that OH-PCB exposure may induce liver injury as well as disrupt the circadian rhythm and peroxisome proliferator-activated receptor (PPAR)-related fatty acid metabolism.
Nonalcoholic fatty liver disease, sleep behaviors, and incident type 2 diabetes
<p><span>Objectives: Nonalcoholic fatty liver disease (NAFLD) is associated with incident type 2 diabetes; however, the extent to which NAFLD may confer its risk remains uncertain, especially in Europeans. Emerging evidence suggests that sleep behaviors are linked to NAFLD and diabetes. We aimed to measure whether sleep behaviors modified the association between NAFLD and incident type 2 diabetes.</span></p> <p><span>Methods: This prospective cohort study included 362,834 participants without type 2 diabetes at baseline in UK Biobank data. Five sleep behaviors, including sleep duration, insomnia, snoring, chronotype, and daytime sleepiness, were collected from the questionnaire. Liver steatosis was based on the fatty liver index.</span></p> <p><span>Results: During a median follow-up of 10.9 years, we documented 7,394 patients with incident type 2 diabetes. NAFLD was significantly associated with increased diabetes risk. Sleeping 7-8 h/day, no insomnia, no self-reported snoring and no frequent daytime sleepiness were independently associated with incident type 2 diabetes, with a 19%, 19%, 13%, and 29% lower risk, respectively. 33.8% and 33.5% of type 2 diabetes events in this cohort could be attributed to NAFLD and poor sleep pattern, respectively. We further found significant interaction between NAFLD and sleep duration and insomnia (<i>P</i> for interaction = 0.027 and 0.025, respectively). Compared those with NAFLD and abnormal sleep duration (≤6 h or ≥9 h) or insomnia, participants with non-NAFLD and normal sleep duration or non-insomnia had 57% (RR 0.43, 95% CI 0.40, 0.47) or 55% (RR 0.45, 95% CI 0.41, 0.50) lower risk of incident diabetes. These associations were independent of age, sex, ethnicity, education, family history, economic status, lifestyles, hemoglobin A1c, systolic blood pressure, total cholesterol, and associated medications.</span></p> <p><span>Conclusion: Both NAFLD and some sleep behaviors were risk factors for type 2 diabetes. Insomnia and sleep duration modified the association between NAFLD and type 2 diabetes.</span></p>
Vitamin D Replacement in Nonalcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT03084328. IPD Sharing: NO. Countries: 1. Publications: 0.
A Trial to Learn if Receiving ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk Factor
ClinicalTrials.gov study NCT06024408. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of LY3885125 in Participants With Dyslipidemia or Non-Alcoholic Fatty Liver Disease (NAFLD)
ClinicalTrials.gov study NCT06007651. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevalence of Non-alcoholic Fatty Liver Disease in Patients With Chronic Kidney Disease in Assiut University Hospitals
ClinicalTrials.gov study NCT04482153. IPD Sharing: Not stated. Countries: 0. Publications: 11.
Metabolic Syndrome and Fatty Liver Disease Among Egyptian Patients with Chronic HBV
ClinicalTrials.gov study NCT06589167. IPD Sharing: NO. Countries: 0. Publications: 13.
Screening for Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD) at Al-Rajhy Hospital Nutrition Clinic. Assiut, Egypt
ClinicalTrials.gov study NCT04861012. IPD Sharing: UNDECIDED. Countries: 0. Publications: 23.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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