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955 results for “phosphate”
Interactions between methylerythritol phosphate (MEP) pathway metabolites and Escherichia coli K-12 fatty acid biosynthesis enzymes
<p>Raw data files from native mass spectrometry analyses examining the interactions between methylerythritol phosphate (MEP) pathway metabolites and Escherichia coli K-12 fatty acid biosynthesis enzymes. Recorded in positive mode direct injection.</p>
Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study
<p>This dataset supports the manuscript titled "Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study." The study aims to compare the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets against metformin in treatment-naïve patients with type 2 diabetes mellitus and glucotoxicity. Data include clinical measurements, laboratory test results, and adverse event records collected throughout the trial period. Statistical analyses were conducted to assess non-inferiority between the two treatment groups. This dataset provides valuable insights for researchers interested in diabetes management, pharmacotherapy, and randomized controlled trials.</p>
Synchrotron imagery of phosphatized eggs in Waptia cf. W. fieldensis from the middle Cambrian (Miaolingian; Wuliuan) Spence Shale of Utah
<p>Exceptionally preserved fossil eggs and embryos provide critical information regarding paleoembryogenesis, reproductive strategies, and the early ontogeny of early arthropods, but the rarity of preservation of both eggs and egg-bearing organisms in situ limits their use in detailed evo-devo studies. Burgess Shale-type deposits preserve rare instances of egg-bearing arthropods as carbonaceous compressions, however, the eggs are usually poorly preserved with no compelling evidence of embryos. We describe the first record of a brooding specimen of <i>Waptia </i>cf. <i>fieldensis</i> from the Spence Shale, a Cambrian (Wuliuan stage) Burgess Shale-type deposit in northeastern Utah and southeastern Idaho. This is the first record of an egg-bearing arthropod from the Spence Shale and it exhibits two distinct modes of preservation among eggs within the single clutch: carbonization and phosphatization. Unlike the egg-bearing Burgess Shale specimens, many eggs of this Utah specimen are also preserved three-dimensionally. In addition, synchrotron radiation X-ray tomographic microscopy reveals internal distributions of mineral phases, along with potential remnants of the egg membrane and attachment structures but, as in the Burgess Shale, no explicit traces of developing embryos. The distinct modes of preservation highlight the existence of diagenetic microenvironments within some eggs but not in others during fossilization.</p>
Effects of Chlorella vulgaris on P release from ferric phosphate sediment by consecutive cultivation
Iron phosphate (Fe-P), the active compound is part of the main storage paths of phosphorus, especially in P-pollution environment. The re-release of Fe-P is a danger sign during microalgae remediation. In this work, pre-incubated Chlorella vulgaris is cultured in BG-11 culture medium with different amounts of quantifying Fe-P. The effects of Fe-P re-release on biomass, flocculation and removal of PO43- are investigated. The results indicated that Chlorella vulgaris can promote the dissolution and release of Fe-P when the pH is 7, the release amount of Fe-P (Q) in 200mL water reaches 0.055-0.45mg d-1 under the Chlorella vulgaris concentration of 5.6×105-8×105cell mL-1. Meanwhile, the growth of Chlorella vulgaris will be inhibited due to flocculation behavior of Fe3+ in the release stage, this goes hand in hand with the specific growth rate of 0.3-0.4d-1 and below 30% phosphorus removal rate. However, this process in the long run means a favorable transformation that Fe-P becomes a bioavailable phosphorus as a resource under the action of Chlorella vulgaris. Microalgae outbreaks may also be triggered by persistent interactions between Fe-P and Chlorella vulgaris. The study provides an important reference for the application of Chlorella vulgaris in a Fe-P rich environment.
Case studies of a multi-product and multiple-sources slurry pipeline network scheduling problem in the phosphate industry
<p>The data shared summarises two case studies of a multi-product and multiple-sources slurry pipeline network scheduling problem in the phosphate industry.</p>
EQ3/6 model results for Randolph-Flagg et al., "Phosphate availability and implications for life on ocean worlds," Nature Communications, 2023
<p>These output files are provided as pickle format at (10.5281/zenodo.7683874) and readable using standard open-source data processing software (<em>e.g.</em>, <a href="https://www.python.org/">https://www.python.org/</a>). The authors declare that the data supporting the findings of this study are available within the paper and supporting information files.</p> <p>Thermodynamic calculations were performed with the program EQ3/6, a thoroughly vetted and commonly used aqueous geochemistry code that computes the equilibrium distribution of dissolved and solid phase species based on a specified initial composition and reaction conditions. For detailed description of please see Randolph-Flagg et al., Nature Communications, 2023.</p>
MD_Simulations_Molecular_mechanisms_of_inorganic-phosphate_release_from_the_core_and_barbed_end_of_actin_filaments
<p>This repository contains the models, protocols, datasets and Jupyter notebooks to reproduce the computational experiments in the paper:</p> <p>"Molecular mechanisms of inorganic-phosphate release from the core and<br> barbed end of actin filaments"</p> <p>by W. Oosterheert, F.E.C Blanc, A. Roy, A. Belyy, M.B. Sanders,, O. Hofnagel, G. Hummer, P. Bieling, S. Raunser</p>
FIGURE 7 in Endophytic fungi associated with Coriaria nepalensis in an abandoned open-pit phosphate mine in Yunnan, P.R. China
FIGURE 7. Phylogram generated from Maximum Likelihood analysis based on a combined LSU, ITS, rpb2 and tub2 sequence datasets. The 71 strains are included in the combined gene analysis 2414 total character including gaps (LSU: 1–970 bp, ITS: 971–1476 bp, rpb2: 1477–2076 bp, tub2: 2077–2414 bp). Tree topology of the ML analysis was similar to the BI. The matrix had distinct alignment patterns, with the final ML optimization likelihood value of -10985.830126 (ln). All free model parameters were estimated by RAxML model, with 591 distinct alignment patterns and 9.91% of undetermined characters or gaps. Estimated base frequencies were as follows: A = 0.239938, C = 0.243524, G = 0.275052, T = 0.241487, with substitution rates AC = 1.455735, AG = 5.319539, AT = 1.539293, CG = 1.013949, CT = 11.131040, GT = 1.000000. The gamma distribution shape parameter alpha = 0.665812 and the Tree-Length = 0.755110. The final average standard deviation of split frequencies at the end of total MCMC generations was calculated as 0.009112 in BI analysis. The species introduced in this study are indicated in red, and the type strains are indicated in bold. Bootstrap values greater than 60% (ML, Left) and Bayesian posterior probabilities (BI, right) greater than 0.95 are given at the nodes. Hypens (-) represent values less than 60% in ML/0.95 in BI.
FIGURE 1 in Endophytic fungi associated with Coriaria nepalensis in an abandoned open-pit phosphate mine in Yunnan, P.R. China
FIGURE 1. Phylogram generated from Maximum Likelihood analysis based on a combined LSU, ITS, tef1-α and tub2 sequence datasets. The 22 strains are included in the combined gene analysis 2460 total character including gaps (LSU: 1–892 bp, ITS: 893–1580 bp, tef1-α: 1581–2065 bp, tub2: 2066–2598 bp). Tree topology of the ML analysis was similar to the BI. The matrix had distinct alignment patterns, with the final ML optimization likelihood value of -11028.098478 (ln). All free model parameters were estimated by RAxML model, with 982 distinct alignment patterns and 24.33% of undetermined characters or gaps. Estimated base frequencies were as follows: A = 0.236385, C =0.275681, G = 0.277948, T = 0.209986, with substitution rates AC = 1.657800, AG = 2.641351, AT = 1.759057, CG = 1.214763, CT = 5.269496, GT = 1.000000. The gamma distribution shape parameter alpha = 0.662280 and the Tree-Length = 1.116951. The final average standard deviation of split frequencies at the end of total MCMC generations was calculated as 0.008871 in BI analysis. The species introduced in this study are indicated in red, and the type strains are indicated in bold. Bootstrap values greater than 60% (ML, Left) and Bayesian posterior probabilities (BI, right) greater than 0.95 are given at the nodes. Hypens (-) represent values less than 60% in ML/0.95 in BI.
FIGURE 4 in Endophytic fungi associated with Coriaria nepalensis in an abandoned open-pit phosphate mine in Yunnan, P.R. China
FIGURE 4. Coniella quercicola (HKAS 129063). (a,e) Obverse and reverse of colonies on PDA; (b–d) Close up of the conidiomata on PDA; (f) Conidiomata; (g) Section of conidiomata; (h) Conidiophores bearing conidiogenous cells and conidia stained by congo red reagent; (i, j) Conidia.
FIGURE 6 in Endophytic fungi associated with Coriaria nepalensis in an abandoned open-pit phosphate mine in Yunnan, P.R. China
FIGURE 6. Chaetomium cochliodes (HKAS 129064). (a,e) Obverse and reverse of colonies on PDA; (b–d) Close up of the fruiting bodies on PDA; (f,g) Ascomata; (h) Asci; (i) Asci stained by the congo red reagents; (j, k) Setae; (l) Immature ascospores stained by congo red reagent; (m, n) Ascospores.
FIGURE 2 in Endophytic fungi associated with Coriaria nepalensis in an abandoned open-pit phosphate mine in Yunnan, P.R. China
FIGURE 2. Chrysofolia kunmingensis (HKAS 129065, holotype). (a,b) Obverse and reverse of colonies on PDA; (c,d) Close up of the fruiting bodies on PDA; (e) Mycelium; (f) Conidiomata; (g–j) Conidiogenous cells bearing conidia which stained by congo red reagent; (k) Conidia stained by congo red reagent.
Study data of : Preparation and evaluation of in situ eye gel with a dual triggered mechanism for the delivery of gatifloxacin and betamethasone sodium phosphate
<p><strong>Preparation and evaluation of in situ eye gel with a dual triggered mechanism for the delivery of gatifloxacin and betamethasone sodium phosphate</strong></p>
A Dose Ranging Study of the Effect of Ruxolitinib Phosphate Cream When Applied to Participants With Plaque Psoriasis
ClinicalTrials.gov study NCT00778700. IPD Sharing: YES. Countries: 1. Publications: 0.
Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency
ClinicalTrials.gov study NCT02594904. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Development of a 'Phosphate Counting Program'
ClinicalTrials.gov study NCT01643486. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Validation of the GIDS and Description of Phosphate Disorders
ClinicalTrials.gov study NCT05909722. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Chloroquine Phosphate Prophylactic Use in Health Personnel Exposed to COVID-19 Patients
ClinicalTrials.gov study NCT04443270. IPD Sharing: NO. Countries: 1. Publications: 12.
FGF23 Reduction : Efficacy of a New Phosphate Binder in CHronic Kidney Disease
ClinicalTrials.gov study NCT01220843. IPD Sharing: Not stated. Countries: 1. Publications: 22.
Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer
ClinicalTrials.gov study NCT00027820. IPD Sharing: Not stated. Countries: 3. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.