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552
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ShareScore release 0.7.1
Dataset results
552 results for “tRNA”
Pairwise and higher order genetic interactions during the evolution of a tRNA
GEO Series GSE99418. Saccharomyces cerevisiae. 8 samples. Type: Genome variation profiling by high throughput sequencing.
Epitranscriptomic regulation of cortical neural stem cell maintenance via Mettl8-dependent mitochondrial tRNA m3C modification
GEO Series GSE214445. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
NCP26 is a potent prolyl-tRNA synthetase inhibitor and induces pro- apoptotic responses with in vivo potency in multiple myeloma
GEO Series GSE186448. Homo sapiens. 92 samples. Type: Expression profiling by high throughput sequencing.
Identifying the transcriptomic effects of tRNA-induced proline-to-serine mistranslation in Drosophila melanogaster
GEO Series GSE256332. Drosophila melanogaster. 12 samples. Type: Expression profiling by high throughput sequencing.
A sperm-enriched 5’fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development
GEO Series GSE281829. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
A non-syndromic orofacial cleft risk locus links tRNA splicing defects to neural crest cell pathologies [Ribo-seq]
GEO Series GSE269561. Homo sapiens. 6 samples. Type: Other.
Polysome Profiling in Isoleucine tRNA Isoswitch Cells
GEO Series GSE172349. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Other.
Oligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [RiboSeq]
GEO Series GSE182810. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis
GEO Series GSE70473. Rattus norvegicus. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Human CLP1 mutations alter tRNA biogenesis affecting both peripheral and central nervous system function
GEO Series GSE53391. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Variant-specific interaction of kinectin 1 with the multi–tRNA synthetase complex regulates ER sheet organization
GEO Series GSE308892. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
Aberrant translation regulation by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives HNSCC progression
GEO Series GSE172146. Mus musculus; Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing.
Translatome and Translation dynamics analysis of a RiboCancer cell line panel reveals that leukemia-associated Rps15 Mutations Rewire Translation through Codon-Specific tRNA Accommodation defects.
GEO Series GSE310057. Mus musculus. 48 samples. Type: Other; Expression profiling by high throughput sequencing.
Quantitative RNA pseudouridine maps reveal multi-layered translation control through plant rRNA, tRNA and mRNA pseudouridylation in arabidopsis total RNA [BID-seq]
GEO Series GSE277198. Arabidopsis thaliana. 36 samples. Type: Other.
Deciphering the reading of the genetic code by near-cognate tRNA
GEO Series GSE108772. Saccharomyces cerevisiae. 2 samples. Type: Expression profiling by high throughput sequencing.
tRNA-derived small non-coding RNAs (tDRs) as novel predictive biomarkers for trastuzumab-resistant breast cancer.
GEO Series GSE107473. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
A giant virus creates a subcellular environment to overcome the codon-tRNA mismatch [RNA-seq]
GEO Series GSE276076. Acanthamoeba castellanii. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution
Mitochondrial protein translation requires interactions between transfer RNAs encoded by the mitochondrial genome (mt-tRNAs) and mitochondrial aminoacyl tRNA synthetase proteins (mt-aaRS) encoded by the nuclear genome. It has been argued that animal mt-tRNAs have higher deleterious substitution rates relative to their nuclear-encoded counterparts, the cytoplasmic tRNAs (cyt-tRNAs). This dynamic predicts elevated rates of compensatory evolution of mt-aaRS that interact with mt-tRNAs, relative to aaRS that interact with cyt-tRNAs (cyt-aaRS). We find that mt-aaRS do evolve at significantly higher rates (exemplified by higher dN and dN/dS) relative to cyt-aaRS, across mammals, birds, and Drosophila. While this pattern supports a model of compensatory evolution, the level at which a gene is expressed is a more general predictor of protein evolutionary rate. We find that gene expression level explains 10-56% of the variance in aaRS dN/dS, and that cyt-aaRS are more highly expressed in addition to having have lower dN/dS values relative to mt-aaRS, consistent with more highly expressed genes being more evolutionarily constrained. Furthermore, we find no evidence of positive selection acting on either class of aaRS protein, as would be expected under a model of compensatory evolution. Nevertheless, the signature of faster mt-aaRS evolution persists in mammalian, but not bird or Drosophila, lineages after controlling for gene expression, suggesting some additional effect of compensatory evolution for mammalian mt-aaRS. We conclude that gene expression is the strongest factor governing differential amino acid substitution rates in proteins interacting with mitochondrial versus cytoplasmic factors, with important differences in mt-aaRS molecular evolution among taxonomic groups.
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress
ClinicalTrials.gov study NCT05514470. IPD Sharing: NO. Countries: 1. Publications: 0.
Mycobacterium tuberculosis tRNA induces IL-12p70 via synergistic activation of pattern recognition receptors within a cell network.
GEO Series GSE110325. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.