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Dataset results
255 results for “tumor associated macrophages;”
GDF15 overexpression dreived from tumor-associated macrophages and cancer cells in the microenvironment of human esophageal squamous cell carcinoma promotes tumor growth and poor prognosis
GEO Series GSE59948. Homo sapiens. 4 samples. Type: Expression profiling by array.
The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages
GEO Series GSE313081. Mus musculus. 4 samples. Type: Other.
Lymphatic-derived 25-hydroxycholesterol promotes immunity in melanoma by inhibiting PPAR-γ in tumor associated macrophages and monocytes
GEO Series GSE242026. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer."
<p>Tumor-associated macrophages (TAMs) represent a major component of the tumor microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a strategy to promote tumor inhibition. However, whether this approach may work in prostate cancer is unknown. Here we find that Pten-null prostate tumors are strongly infiltrated by TAMs expressing C-X-C chemokine receptor type 2 (CXCR2), and activation of this receptor through CXCL2 polarizes macrophages toward an anti-inflammatory phenotype. Notably, pharmacological blockade of CXCR2 receptor by a selective antagonist promoted the re-education of TAMs toward a pro-inflammatory phenotype. Strikingly, CXCR2 knockout monocytes infused in Pten<sup>pc-/-</sup>; Trp53<sup>pc-/-</sup> mice differentiated in tumor necrosis factor alpha (TNF-α)-releasing pro-inflammatory macrophages, leading to senescence and tumor inhibition. Mechanistically, PTEN-deficient tumor cells are vulnerable to TNF-α-induced senescence, because of an increase of TNFR1. Our results identify TAMs as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.</p> <p> </p> <p>This dataset contain some prism documents, in order to help we attach a pdf information file about it</p>
Dataset related to article "Macrophage morphology of tumor-associated macrophages as a correlate of metabolism with prognostic significance in colorectal liver metastases"
<p>This record contains data related to article "Morphology of tumor-associated macrophages as a correlate of metabolism with prognostic significance in colorectal liver metastases"</p> <p>Abstract</p> <p>It has long been known that in vitro polarized macrophages differ in morphology. Stemming from a conventional immunohistology observation, we set out to test the hypothesis that morphology of tumor-associated macrophages (TAMs) in colorectal liver metastasis (CLM) represents a correlate of functional diversity with prognostic significance. Density and morphological metrics of TAMs were measured and correlated with clinicopathological variables. While density of TAMs did not correlate with survival of CLM patients, the cell area identified small (S-TAM) and large (L-TAM) macrophages that were associated with 5-yr disease-free survival rates of 27.8% and 0.2%, respectively (P < 0.0001). RNA sequencing of morphologically distinct macrophages identified LXR/RXR as the most enriched pathway in large macrophages, with upregulation of genes involved in cholesterol metabolism, scavenger receptors, MERTK, and complement. In single-cell analysis of mononuclear phagocytes from CLM tissues, S-TAM and L-TAM signatures were differentially enriched in individual clusters. These results suggest that morphometric characterization can serve as a simple readout of TAM diversity with strong prognostic significance.</p>
Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"
<p>This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". </p> <p>A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their protumoral functions is actively pursued, with the purpose of relieving this state of immunesuppression. We previously reported that trabectedin, a registered antitumor compound, selectively reduces monocytes and TAMs in treated tumors. However, its putative effects on the adaptive immunity are still unclear. In this study, we investigated whether treatment of tumor-bearing mice with trabectedin modulates the presence and functional activity of T-lymphocytes. In treated tumors, there was a significant upregulation of T cell-associated genes, including CD3, CD8, perforin, granzyme B, and IFN-responsive genes (MX1, CXCL10, and PD-1), indicating that T lymphocytes were activated after treatment. Notably, the mRNA levels of the Pdcd1 gene, coding for PD-1, were strongly increased. Using a fibrosarcoma model poorly responsive to PD-1-immunotherapy, treatment with trabectedin prior to anti-PD-1 resulted in improved antitumor efficacy. In conclusion, pretreatment with trabectedin enhances the therapeutic response to checkpoint inhibitor-based immunotherapy. These findings provide a good rational for the combination of trabectedin with immunotherapy regimens.</p> <p> </p>
Dataset related to article "Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer "
<p>This record contains raw data related to article “Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer"</p> <p>Abstract</p> <p>Tumor-associated macrophages (TAMs) have a unique favorable effect on the prognosis of colorectal cancer (CRC), although their association with stage-specific outcomes remains unclear. We assessed the densities of CD68<sup>+</sup> and CD163<sup>+</sup> TAMs at the invasive front of resected CRC stage III CRC from 236 patients, 165 of whom received post-surgical FOLFOX treatment, and their relationship with disease-free survival (DFS). Associations between macrophage mRNAs and clinical outcome were investigated in silico in 59 stage III CRC and FOLFOX-treated patients from The Cancer Genome Atlas (TCGA). Biological interactions of SW480 and HT29 cells and macrophages with FOLFOX were tested in co-culture models. Low TAM densities were associated with shorter DFS among patients receiving FOLFOX (CD68<sup>+</sup> , p = 0.0001; CD163<sup>+</sup> , p = 0.0008) but not among those who were untreated. By multivariate Cox analysis, only low TAM (CD68<sup>+</sup> , p = 0.001; CD163<sup>+</sup> , p = 0.002) and nodal status (CD68<sup>+</sup> , p = 0.009; CD163<sup>+</sup> , p = 0.007) maintained an independent predictive value. In the TCGA cohort, high CD68 mRNA levels were associated with better outcome (p = 0.02). Macrophages enhanced FOLFOX cytotoxicity on CRC cells (p < 0.01), and drugs oriented macrophage polarization from M2- to M1-phenotype. Low TAM densities identify stage III CRC patients at higher risk of recurrence after adjuvant therapy, and macrophages can augment the chemo-sensitivity of micro-metastases.</p> <p><strong>Keywords: </strong></p>
Periostin promotes sarcoma growth by increasing tumor associated macrophages. [RNA-Seq 1]
GEO Series GSE302278. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeting LRRC25 enhances antitumor immunity of tumor-associated macrophages through CD8+ T cells [scRNA-seq]
GEO Series GSE264446. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Sin1-mTORC2 Augments Lipid Anabolism of Tumor-associated Macrophages to Limit the Type I Interferon-dependent Anti-tumor Immunity
GEO Series GSE198880. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Intracellular activation of complement C3 leads to PD-L1 antibody treatment resistance via modulating tumor-associated macrophages
GEO Series GSE120274. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Tumor-associated macrophages (TAMs) with or without HRS knockdown (KD)
GEO Series GSE302643. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Precision nanotherapy remodels the tumor-associated macrophage to reverse immunnosuppressive in pancreatic cancer [scRNA-seq]
GEO Series GSE313718. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome sequencing of tumor associated macrophages cells in HCC liver of OXCT1mKO mice.
GEO Series GSE237917. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
mRNA profiling of schwann cells cultured with monocytes derived macrophages and PDAC cell lines supernants-induced tumor-associated macrophages (TAMs)
GEO Series GSE194205. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
mRNA profiling of monocytes derived macrophages and PDAC cell lines supernants-induced tumor-associated macrophages (TAMs)
GEO Series GSE194191. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Whole-course Taming of Tumor-associated Macrophages from Central to Peripheral using Engineered Outer Membrane Vesicle Nanohybrids for Improved Immunotherapy [part 1: RNA-seq]
GEO Series GSE212259. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Blocking CX3CR1+ Tumor-associated Macrophages Synergize with anti-PD-1 Therapy in Hepatocellular Carcinoma
GEO Series GSE263240. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients
GEO Series GSE192935. Homo sapiens; Mus musculus. 58 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics reveals ferrimagnetic vortex nanoring-mediated mild magnetic hyperthermia exerts antitumor effects by alleviating tumor-associated macrophages suppression
GEO Series GSE241188. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.