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Dataset results
2,489 results for “Sars-CoV-2”
Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population III
GEO Series GSE246819. synthetic construct; Homo sapiens; Severe acute respiratory syndrome coronavirus 2. 2060 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in lungs from SARS-CoV-2 mice treated with biguanides [RNAseq_murine]
GEO Series GSE195721. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
GEO Series GSE239588. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
SARS-CoV-2 NSP14 Inhibitor Confers Potent Antiviral Efficacy and Reverses NSP14-triggered Host Cell Modulation
GEO Series GSE290079. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
A Platform to Define Cellular Targets of SARS-COV-2 Infection Using Human Pluripotent Stem Cell-Derived Cells and Organoids
GEO Series GSE147903. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Mapping the 3D genome and epigenome in SARS-CoV-2 infected human cells
GEO Series GSE179184. Homo sapiens. 65 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
SARS-CoV-2 infection induces transcriptomic alterations specific to activation of innate immunity and cellular distress.
GEO Series GSE156005. Mesocricetus auratus. 16 samples. Type: Expression profiling by high throughput sequencing.
SARS-COV-2 putative mi-RNAs may target host immune system and cellular mechanisms to mediate pathogenesis-an in silico and in vivo study II
GEO Series GSE231529. Homo sapiens. 12 samples. Type: Expression profiling by RT-PCR.
An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection
GEO Series GSE214772. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis
GEO Series GSE162323. Homo sapiens; Severe acute respiratory syndrome coronavirus 2. 42 samples. Type: Expression profiling by high throughput sequencing; Other.
Histone H4 is increased in SARS-CoV-2-infected lung epithelial cells and linked to COVID-19 severity
GEO Series GSE167410. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [scRNA-Seq]
GEO Series GSE236941. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF-κB pathway towards SARS-CoV-2 (RNA-Seq depeted total)
GEO Series GSE244485. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 infection of human embryonic stem cell-derived lung organoids
GEO Series GSE155717. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling of circulating endothelial cells in SARS-CoV-2-infected cynomolgus macaques
GEO Series GSE287567. Macaca fascicularis. 6 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive comparison of adaptive immune response by inactivated SARS-CoV-2 vaccine between young and old
GEO Series GSE191089. Homo sapiens. 9 samples. Type: Other; Expression profiling by high throughput sequencing.
Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load
GEO Series GSE234486. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
Data sets for Perspective: SARS-CoV-2's potential mechanism of regulating cellular responses through depletion of specific host miRNAs
<p>Using a bioinformatic analysis of human miRNA potential interactions with the SARS-CoV-2’s genome, we examined the potential miRNA target sites in 7 coronavirus genomes that include SARS-CoV-2, MERS-CoV, SARS-CoV, and 4 non-pathogenic coronaviruses. (<strong>Data Set 1</strong>).</p> <p><em>Our approach was to examine and compare 3 pathogenic and 4 non-pathogenic strains of HCoVs. The HCoVs' RNA genomes of pathogenic strains were SARS-CoV-2 (NC_045512.2), SARS-CoV (NC_004718.3), MERS-CoV (NC_019843.3). The non-pathogenic strains were HCoV-OC43 (KU131570.1), HCoV-229E (NC_002645.1), HCoV-HKU1 (KF686346.1), and HCoV-NL63 (NC_005831.2). These coronaviruses were tested against the set of 896 confident mature human miRNA sequences that were obtained from the miRBbase v2.21 using the RNA22 v2 microRNA target discovery tool web-server. In order to reduce the false discovery rate of the MTS predictions, the most strict parameters were applied to the default computation workflow using a specificity of 92% versus a sensitivity of 22%.</em></p> <p><em>In <strong>Data set 2</strong>, using the miRDIP database with only top 1% of the most probable targets considered, we analyzed the potential targets of miRNA that could be bound to either the pathogenic, the non-pathogenic or both groups of HCoVs. </em></p> <p>In <strong>Data set 3</strong>, using miRNAFold webserver we identified 10 pre-miRNA sequences in the <em>SARS-CoV-2</em> RNA sequence that could potentially enter the human RNAi pathway.</p> <p>The graphical summary of our working hypothesis is provided in the<strong> graphical abstract</strong>.</p> <p> </p> <p> </p>
Dataset related to the article "Presence of SARS-CoV-2 nucleoprotein in cardiac tissues of donors negative to COVID-19 molecular tests"
<p>This record contains raw data related to the article “Presence of SARS-CoV-2 nucleoprotein in cardiac tissues of donors negative to COVID-19 molecular tests”</p> <p> </p> <p>Abstract</p> <p><strong>Background:</strong> COVID-19 outbreak caused detrimental effects on essential medical services as organ and tissue donation. Lombardy, one of the most active Italian region in organ/tissue procurement, has been strongly affected by the COVID-19 pandemic. To date, data concerning the risk of SARS-CoV-2 transmission after tissue transplantation are controversial. Here we aim to evaluate the presence/absence of SARS-CoV-2 in different cardiac tissues eligible for transplantation obtained from Lombard donors.</p> <p><strong>Methods and Results:</strong> We used cardiovascular tissues from eight donors potentially suitable for pulmonary valve transplantation. All donor subjects involved in the study were negative for the SARS-CoV-2 RNA molecular tests (qRT-PCR and chip-based digital PCR) in NPS and/or BAL. None of the 8 donors included in this study revealed viral genome SARS-CoV-2 presence. However, the evaluation of protein content of pulmonary vein wall (PVW) tissue revealed in all donors variable levels of SARS-CoV-2 nucleoprotein signal.</p> <p><strong>Conclusion:</strong> Our study demonstrated for the first time, to the best of our knowledge, that, viral nucleoprotein but not viral RNA was present in the tissue bank examined specimens, suggesting caution and in-depth investigations on implantable tissue specimens collected during COVID-19 pandemic period.</p>
Changing in adaptive cellular repertoire after different SARS-CoV-2 VOCs infection in a cohort of vaccinated Healthcare workers
<p>Despite currently approved vaccines are highly effective in protecting against hospitalization and severe Covid-19 infections, however, their effectiveness in counteracting symptoms presentation and breakthrough infections appears to decrease over time. How pre-existing immunity responds to new variants with mutated antigens is a crucial information to elucidate the functional interplay between antibodies, B and T cell responses during infection with new SARS-CoV-2 variants. In this study, we monitored the dynamics and persistence of the immune response versus different SARS-CoV-2 variants of concern emerged during the pandemic period (2021-2022), in a cohort of vaccinated health care workers, who experienced breakthrough infection in the Pre-Delta, Delta and Omicron waves. Our results suggest a direct dependence between VOCs and different humoral and B and T cells balance in the post-infection period, despite the administration of a different number of vaccine doses and the elapsed time since the last vaccination.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.