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2,489 results for “Sars-CoV-2”
Dataset for "Vaccination Effects on SARS-CoV-2 Intra-Host Evolution During São Paulo's Delta and Omicron Waves"
<p><span>The COVID-19 pandemic, driven by SARS-CoV-2, has led to intensive vaccination campaigns worldwide. Despite widespread vaccination, the potential for vaccine escape variants necessitates ongoing research into the virus’s intra-host evolutionary dynamics. In this study we investigated the effects of vaccination on SARS-CoV-2 intra-host evolution during the Delta and Omicron waves in São Paulo, Brazil, analyzing 700 SARS-CoV-2 positive samples collected through the LabMovel initiative, from August 2021 to March 2022. Samples were categorized based on vaccination status (Unvaccinated, Spike protein-based vaccines, and Whole inactivated virus vaccine), enabling comparison of intra-host viral diversity across vaccinated and unvaccinated individuals for both Delta and Omicron VOCs. We evaluated intra-host genetic diversity by measuring intra-host single nucleotide variants (iSNVs), Faith's Phylogenetic Diversity (PD), and haplotype diversity using Normalized Shannon Entropy. For Delta, vaccinated groups exhibited higher haplotype diversity, yet no statistically significant difference was observed in the total number of iSNVs between vaccinated and unvaccinated individuals. Selective pressures in the Delta VOC showed neutral selection in vaccinated individuals, contrasting with purifying selection in unvaccinated individuals, though effect sizes were minimal. For Omicron, a bimodal distribution in Faith's PD across all groups suggests genetic drift events, aligning with Omicron’s rapid spread and high transmissibility. Observed intra-host diversity patterns were variant-specific, with Spike-based vaccines associated with a lower number of haplotypes in Omicron cases. These findings suggest that vaccination modulates SARS-CoV-2’s intra-host evolution, likely contributing to its mutational landscape in a variant-dependent manner. The results highlight variant-specific responses to vaccination, emphasizing the complex role of selective pressures in SARS-CoV-2 intra-host evolution. Our findings support ongoing genomic surveillance to understand vaccination's evolutionary impact on intra-host viral dynamics, particularly as new variants emerge.</span></p>
Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target
<p>In this dataset, we have validated and explored the interaction between the SARS-CoV-2 M protein and the cellular protein PCNA, an interaction that was previously described by another proteomics study (Gordon et al., 2020). PCNA is an important nuclear protein involved in DNA replication and repair in the cell. The M-protein-PCNA interaction characterized here impacted the cell physiology, including increased localization of PCNA in the cytoplasm and associated DNA damage markers. These phenomena may have consequences for the fate of cells infected with SARS-CoV-2 and for the outcomes of COVID-19, such as persistent DNA damage after the infection. Finally, we show that inhibitors of PCNA and cell nuclear transport present effects in SARS-CoV-2 replication in vitro. Similar results have been presented by other RNA viruses in the literature. In sum, this study sheds light on novel molecular mechanisms of SARS-CoV-2 replication.</p>
Covid-associated Multisystem Inflammatory Syndrome in Children and Cardiovascular Autonomic Control: a Prospective Cohort Study Nine Months after SARS-CoV-2 Infection. DATASET
<p><span>The data that support the main findings of this study have been uploaded on the Zenodo repository with access granted on justified request to researchers who meet the criteria for access to confidential data due to the restrictions requested for approval by the local ethical committee.</span></p>
Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection
ClinicalTrials.gov study NCT04409184. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Single-cell RNA-sequencing of human bronchial epithelial organoids infected by four different betacoronaviruses; HCoV-OC43, SARS-CoV, MERS-CoV, and SARS-CoV-2 and mock control.
GEO Series GSE262439. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 produces a diverse small viral RNA landscape capable of targeting host transcripts
GEO Series GSE197521. Chlorocebus aethiops; Homo sapiens. 99 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Systems analysis of interaction between p38/MAPK pathway and SARS-CoV-2
GEO Series GSE183999. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Antigen-reactive CD4 T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation [separate samples]
GEO Series GSE310441. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
An autonomous intrapulmonary inflammatory feedback response, mediated by surfactants, operates as an inherent viral defense mechanism: evidence from acute SARS-CoV-2 infection [Prox, Distal, and Whole
GEO Series GSE214762. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Whole transcriptome exploration revealed the dysregulated RNAs involved in SARS-CoV-2 spike protein inhibited apoptosis in Calu-3 cells
GEO Series GSE201325. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiles of whole blood from SARS-CoV-2 rhesus macaques
GEO Series GSE155363. Macaca mulatta. 48 samples. Type: Expression profiling by high throughput sequencing.
Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states
GEO Series GSE236942. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Whole blood transcriptome analysis reveals SARS-CoV-2 ORF8 as a potential therapeutic and vaccine target
GEO Series GSE155454. Homo sapiens. 58 samples. Type: Expression profiling by high throughput sequencing.
Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
GEO Series GSE186475. Homo sapiens. 5 samples. Type: Other.
CITE-seq of peripheral immune cells after SARS-COV-2 vaccination in patients with MM
GEO Series GSE229187. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Human dendritic cell and macrophage response to SARS-CoV-2 infection
GEO Series GSE155106. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Host transcriptional responses to SARS-CoV-2 infection in a human nose organoid model
GEO Series GSE234484. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Potential Role of Inflammation in SARS-CoV-2 Disease Pathology: A multi-omic study in Type II pneumocytes of A/J mice exposed to Lipopolysaccharide
GEO Series GSE211061. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Halofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp1]
GEO Series GSE157032. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
The transcriptomic landscape of PBMC in SARS-CoV-2 variants-infected Rhesus monkeys via digital RNA-seq analysis
GEO Series GSE246985. Macaca mulatta. 20 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.