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2,470
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Dataset results
2,470 results for “Acute myeloid leukemia”
Hematopoietic stem and progenitor cells in experimental remission model of acute myeloid leukemia in vivo [RNA-seq]
GEO Series GSE280873. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Effect of CRISPR knockout of MLL, CSNK2A1 and SGF29 on gene expression profiles in acute myeloid leukemia U937 cells [RNA-seq]
GEO Series GSE217776. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Screening microRNA-196 targets in 11q23-translocation acute myeloid leukemia reveal mechanisms maintaining leukemia stemness with therapeutic potential
GEO Series GSE75843. Homo sapiens; Mus musculus. 26 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Transformation of megakaryocyte-erythroid progenitors to acute myeloid leukemia-initiating cells
GEO Series GSE119303. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia
GEO Series GSE221459. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A phase 1 study of the CDK9 inhibitor voruciclib in relapsed/refractory acute myeloid leukemia and B-cell malignancies
GEO Series GSE281161. Homo sapiens. 31 samples. Type: Expression profiling by high throughput sequencing.
Subtype-specific regulatory network rewiring in acute myeloid leukemia [DNase-Hypersensitivity]
GEO Series GSE108246. Homo sapiens. 33 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Subtype-specific regulatory network rewiring in acute myeloid leukemia [RNA-seq]
GEO Series GSE108266. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Single-cell profiling of Acute Myeloid Leukemia for high-resolution chemo-immunotherapy target discovery
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000007.
Germline Genetics of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Myelodysplastic syndromes (MDS) are part of a heterogeneous and overlapping group of clonal diseases that arise in the hematopoietic stem or progenitor cells and also include acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and the hybrid MDS/MPN entities. Individuals with MDS have a high risk of progressing to leukemia, with approximately 30% expected to develop AML. This study evaluates genetic susceptibility to myeloid malignancy using data from population-based case control studies of myelodysplastic syndromes and acute myeloid leukemia in adults (ages 18-85 years) and pediatric MDS cases with banked samples at the Center for International Blood and Marrow Transplant Research (CIBMTR). Adult cases were identified through the Minnesota Cancer Reporting System and controls were recruited from the State Driver's License/Identification Card list. DNA samples were collected via mouthwash collection kits (AML cases and controls) or Oragene saliva collection kits (adult MDS cases and controls). Pediatric MDS samples were banked at CIBMTR prior to receipt of a transplant and DNA was extracted from isolated T cells or whole blood samples. Genotyping data were generated using the Illumina Global Diversity array and quality control and genotype calling was conducted using established best practices. Our primary analyses investigated the contribution of genetic variation to MDS risk and evaluated the role of the killer cell immunoglobulin receptors (KIR) on incidence and survival.
TARGET: Acute Myeloid Leukemia (AML)
There are 200+ fully characterized patient cases with AML (all tumor/normal pairs, 100 with relapse sample as well) that make up the TARGET AML dataset, each with gene expression, tumor and paired normal copy number analyses, methylation and comprehensive next-generation sequencing to include whole genome sequencing, mRNA-seq and miRNA-seq. A subset of these cases will also have whole exome sequencing data available as well. There are additionally a large number of cases with partial molecular characterization making this a large and informative genomic dataset. Additionally, the TARGET AML cohort includes some highly aggressive subtypes including AML "induction failures." Upon diagnosis, AML patients without high-risk genetic markers undergo standard chemotherapy, called the primary induction phase. This phase lasts about 30 days and is designed to eliminate cancer cells. Success of treatment is measured by the percentage of myeloblasts, i.e. immature white blood cells, detected in the patient following primary induction. Patients with greater than 15% myeloblasts did not sufficiently respond to standard therapy and are "induction failures." Currently, these patients have very poor prognoses and few clinical options. There are 30 patient cases that make up the TARGET AML Induction failure dataset, each with a primary tumor sample, a "normal" fibroblast sample grown from the patient's bone marrow, and a sample obtained at the end of induction. The trios for each case are characterized with next generation sequencing platforms to include whole genome, miRNA-Seq and mRNA-Seq. Gene expression and copy number analyses were also determined from mRNA-seq and whole genome sequencing respectively.
Anti-proliferative effect of Cinobufagin on acute myeloid leukemia cells with repression of c-Myc pathway associated genes (ChIP-Seq)
GEO Series GSE190995. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with complex karyotype
GEO Series GSE115154. Homo sapiens. 16 samples. Type: Expression profiling by array.
Aryl hydrocarbon receptor antagonism allows sustained culture of leukemia progenitor cells from acute myeloid leukemia patients
GEO Series GSE55242. Homo sapiens. 14 samples. Type: Expression profiling by array.
Transformation of megakaryocyte-erythroid progenitors to acute myeloid leukemia-initiating cells: Cut&Run
GEO Series GSE119302. Mus musculus. 6 samples. Type: Other.
Transcriptome analysis of blast Side and Main populations cells in patients with acute myeloid leukemia
GEO Series GSE114633. Homo sapiens. 4 samples. Type: Expression profiling by array.
Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia [CUT&RUN]
GEO Series GSE186130. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway
GEO Series GSE28185. Homo sapiens. 8 samples. Type: Expression profiling by array.
CRISPR Phenotypic enrichment screen for epigenetic regulators of MEIS1 expression in acute myeloid leukemia (AML) [CRISPRScreens]
GEO Series GSE217778. Homo sapiens. 6 samples. Type: Other.
RNA-seq in murine acute myeloid leukemia (AML) cells with and without knockdown of Tet1
GEO Series GSE116548. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.