Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,552
datasets available to search
ShareScore release 0.9.0
Dataset results
2,552 results for “Glioblastoma”
Dynamic alteration of cancer stem cell regulators in glioblastoma through radiation-induced mesenchymal transition
GEO Series GSE113149. Homo sapiens. 4 samples. Type: Expression profiling by array.
On the effects of 30 GHz sinusoidal wave exposure on glioblastoma organoids
GEO Series GSE239486. Homo sapiens. 18 samples. Type: Expression profiling by array.
Frequent driver mutations in histone H3.3 and chromatin remodeling genes in paediatric glioblastoma
Whole exome sequencing identified frequent driver mutations in a series of paediatric glioblastomas. We used microarray-based profiling to investigate differences in gene expression according to mutational status of driver genes.
Gene expression data from glioblastoma tumor samples
Glioblastoma (GBM) is an incurable brain tumor carrying a dismal prognosis, which displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical positions of histone H3.3 (K27, G34) in one-third of pediatric GBM. Here we show that each of these H3F3A mutations defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and are mutually exclusive with IDH1 mutation (characterizing a CpG-Island Methylator Phenotype (CIMP) subgroup). Three further epigenetic subgroups were enriched for hallmark genetic events of adult GBM (EGFR amplification, CDKN2A/B deletion) and/or known transcriptomic signatures. We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of OLIG1/2 and FOXG1, possibly reflecting different cellular origins. To further dissect the biological differences between epigenetic glioblastoma subgroups, we looked at the transcriptomic profiles of glioblastoma samples.
Differences in transcriptomic profiles between glioblastoma-initiating cells (GICs) and non-GICs upon radiation treatment
GEO Series GSE82139. Homo sapiens. 14 samples. Type: Expression profiling by array.
Dataset related to article "Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study "
<p>This record contains raw data related to article “Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study "</p> <p>( 1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18-70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (<em>p</em> = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform.</p>
Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy. [RNA-Seq]
GEO Series GSE249544. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
mTORC1-Driven DDA1 Phosphorylation Promotes DNA Repair and Glioblastoma Progression
GEO Series GSE303079. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy. [array]
GEO Series GSE249636. Homo sapiens. 36 samples. Type: Methylation profiling by array.
Lactic Acid as an Epigenetic Metabolite in Glioblastoma [ATAC-Seq]
GEO Series GSE162831. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data from glioblastoma tissue and matched adjacent normal tissue
GEO Series GSE65626. Homo sapiens; synthetic construct. 12 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Bone marrow stromal cell antigen 2 is a novel therapeutic target of glioblastoma stem cells
GEO Series GSE85024. Homo sapiens. 2 samples. Type: Expression profiling by array.
Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity
GEO Series GSE122809. Homo sapiens. 38 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
An engineered glioblastoma model yields macrophage-secreted drivers of invasion
GEO Series GSE251777. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of circulating tumor DNA methylation profiles in cerebrospinal fluid: a clinical trial of oncolytic virus for glioblastoma [mRNA-Seq]
GEO Series GSE205590. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Differentiation of Mesenchymal Glioblastoma Multiform by Bexarotene
GEO Series GSE61002. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genome-wide analysis of circulating tumor DNA methylation profiles in cerebrospinal fluid: a clinical trial of oncolytic virus for glioblastoma [MeDIP-Seq]
GEO Series GSE205519. Homo sapiens. 8 samples. Type: Methylation profiling by high throughput sequencing.
Gene expression data from nine pediatric glioblastoma tumor samples
GEO Series GSE134404. Homo sapiens. 9 samples. Type: Expression profiling by array.
CD15-positive tumor-derived glioblastoma cells
GEO Series GSE103366. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide methylation analysis of cerebrospinal fluid circulating tumor DNA: a new biomarker for recurrent glioblastoma [mRNA-Seq]
GEO Series GSE205512. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.