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Dataset results
254 results for “Abdominal aortic aneurysm”
Erythropoietin promotes abdominal aortic aneurysm via angiogenesis and inflammatory infiltration in Apoe-/- and wild type mice
GEO Series GSE174556. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
SM22α-lineage stromal cells in perivascular adipose tissue contribute to abdominal aortic aneurysm
GEO Series GSE293558. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genetic deficiency of C–C chemokine receptor 4 protects against angiotensin II-induced abdominal aortic aneurysm formation in mice
GEO Series GSE292493. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Atherosclerotic process regulates arterial damage, abdominal aortic aneurysm (AAA) formation and rupture
GEO Series GSE224587. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
The spatiotemporal expression profile of ATF3 determines the fate of smooth muscle cells in abdominal aortic aneurysm development
GEO Series GSE261595. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in human abdominal aortic aneurysm wall biopsie with high or low wall stress
GEO Series GSE205071. Homo sapiens. 24 samples. Type: Expression profiling by array.
Targeting of lncRNA Morrbid inhibits abdominal aortic aneurysm by regulating macrophage-mediated vascular inflammation.
GEO Series GSE230157. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression data in Abdominal Aortic Aneurysms
GEO Series GSE165470. Homo sapiens. 10 samples. Type: Expression profiling by array.
Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms.
<p>Dataset from Mazzaccaro D, Avishay D, Nano G. Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms. Ann Vasc Surg. 2021 Nov 4:S0890-5096(21)00790-1. doi: 10.1016/j.avsg.2021.08.053. Epub ahead of print. PMID: 34743010.</p> <p>Abstract</p> <p><strong>Background: </strong>To assess the factors affecting visceral suitability of the use of the Zenith T-branch<sup>TM</sup> system in a group of patients with thoraco-adbominal aortic aneurysms (TAAAs).</p> <p><strong>Methods: </strong>Computer tomography angiography (CTA) of patients who presented a TAAA from 01/2015 to 12/2019 were retrospectively examined. Multi-Planar Reconstructions were performed on CTA images to assess the anatomic suitability of the Zenith T-branch in the visceral district. In particular, the branch deviation angle (BDA), and the branch-length were computed for each target vessel.</p> <p><strong>Results: </strong>Fifty-four CTA were examined. In 33.3% of these patients the presence of either a common origin of the superior mesenteric artery and the celiac trunk, or the diameter of 1 or more visceral/renal artery limited the visceral suitability of the device. All patients except 1 (97.9%) fitted the BDA criterion when the graft was placed in a position in which the BDA for the SMA was 5 degrees to the left. The branch-length criteria was met in all patients, except for 1 (97.9%), when the graft was placed in the center of the aorta. The eccentrical placement of the endograft decreased the suitability to 93.7%.</p> <p><strong>Conclusions: </strong>The Zenith T-branch system can be suitable in the visceral district for about 67% of patients. The target artery diameter was the most limiting criterion. The central location of the graft within the aortic lumen significantly affected the branch-length distance criteria.</p>
DataSet_Simultaneous versus staged approach in transcatheter aortic valve implantation for severe stenosis and endovascular aortic repair for thoracic and abdominal aortic aneurysm
Open the record for dataset details and reuse information.
Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms
<p>Mazzaccaro D, Avishay D, Nano G. Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms. Ann Vasc Surg. 2022 Apr;81:113-120. doi: 10.1016/j.avsg.2021.08.053. Epub 2021 Nov 4. PMID: 34743010.</p> <p>Abstract</p> <p><strong>Background: </strong>To assess the factors affecting visceral suitability of the use of the Zenith T-branch<sup>TM</sup> system in a group of patients with thoraco-adbominal aortic aneurysms (TAAAs).</p> <p><strong>Methods: </strong>Computer tomography angiography (CTA) of patients who presented a TAAA from 01/2015 to 12/2019 were retrospectively examined. Multi-Planar Reconstructions were performed on CTA images to assess the anatomic suitability of the Zenith T-branch in the visceral district. In particular, the branch deviation angle (BDA), and the branch-length were computed for each target vessel.</p> <p><strong>Results: </strong>Fifty-four CTA were examined. In 33.3% of these patients the presence of either a common origin of the superior mesenteric artery and the celiac trunk, or the diameter of 1 or more visceral/renal artery limited the visceral suitability of the device. All patients except 1 (97.9%) fitted the BDA criterion when the graft was placed in a position in which the BDA for the SMA was 5 degrees to the left. The branch-length criteria was met in all patients, except for 1 (97.9%), when the graft was placed in the center of the aorta. The eccentrical placement of the endograft decreased the suitability to 93.7%.</p> <p><strong>Conclusions: </strong>The Zenith T-branch system can be suitable in the visceral district for about 67% of patients. The target artery diameter was the most limiting criterion. The central location of the graft within the aortic lumen significantly affected the branch-length distance criteria.</p>
Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms
<p>Mazzaccaro D, Avishay D, Nano G. Factors Affecting the Visceral Suitability of a Multibranched off-the-Shelf Endograft for the Treatment of Thoraco-Abdominal Aortic Aneurysms. Ann Vasc Surg. 2022 Apr;81:113-120. doi: 10.1016/j.avsg.2021.08.053. Epub 2021 Nov 4. PMID: 34743010.</p> <p>Abstract</p> <p><strong>Background: </strong>To assess the factors affecting visceral suitability of the use of the Zenith T-branch<sup>TM</sup> system in a group of patients with thoraco-adbominal aortic aneurysms (TAAAs).</p> <p><strong>Methods: </strong>Computer tomography angiography (CTA) of patients who presented a TAAA from 01/2015 to 12/2019 were retrospectively examined. Multi-Planar Reconstructions were performed on CTA images to assess the anatomic suitability of the Zenith T-branch in the visceral district. In particular, the branch deviation angle (BDA), and the branch-length were computed for each target vessel.</p> <p><strong>Results: </strong>Fifty-four CTA were examined. In 33.3% of these patients the presence of either a common origin of the superior mesenteric artery and the celiac trunk, or the diameter of 1 or more visceral/renal artery limited the visceral suitability of the device. All patients except 1 (97.9%) fitted the BDA criterion when the graft was placed in a position in which the BDA for the SMA was 5 degrees to the left. The branch-length criteria was met in all patients, except for 1 (97.9%), when the graft was placed in the center of the aorta. The eccentrical placement of the endograft decreased the suitability to 93.7%.</p> <p><strong>Conclusions: </strong>The Zenith T-branch system can be suitable in the visceral district for about 67% of patients. The target artery diameter was the most limiting criterion. The central location of the graft within the aortic lumen significantly affected the branch-length distance criteria.</p>
Datasset to the publication: Application and challenges of TCR and BCR sequencing to investigate T and B cell clonality in abdominal aortic aneurysm
<p>Title: Application and challenges of TCR and BCR sequencing to investigate T and B cell clonality in abdominal aortic aneurysm</p> <p>Abstract:<br>Background: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease.32<br>Although its pathogenesis is still poorly understood, recent evidence suggests that AAA displays33<br>characteristics of an autoimmune disease. Particularly T cells responding to AAA-related antigens in34<br>the aortic wall may contribute to the initial immune response. Single-cell RNA (scRNA) T- and B- cell35<br>receptor (TCR and BCR) sequencing is a powerful tool to investigate clonality. However, difficulties36<br>such as limited numbers of isolated cells must be considered during implementation and data analysis,37<br>making biological interpretation challenging. Here, we perform a representative single cell immune38<br>repertoire analysis in experimental murine AAA and show a reliable bioinformatic processing pipeline39<br>highlighting opportunities and limitations of this approach.40<br>Methods: We performed scRNA TCR and BCR sequencing of isolated lymphocytes from the41<br>infrarenal aorta of male C57BL/6J mice 3, 7, 15, and 28 days after AAA induction via elastase42<br>perfusion of the aorta. Sham-operated mice at day 3 and 28 as well as non-operated mice served as43<br>controls.44<br>Results: Comparison of complementarity-determining region (CDR3) length distribution of 179 B45<br>cells and 796 T cells revealed neither differences between AAA and control nor between the disease46<br>stages. We found no clonal expansion of B cells in AAA. For T cells, we identified expanded clones47<br>in 11 of 16 AAA samples and in 1 of 8 control samples. Immune receptor repertoire comparison48<br>indicated that only few clones were shared between the individual AAA samples. The most frequently49<br>used V-genes in the TCR beta chain in AAA were TRBV3, TRBV19, and the splicing variant50<br>TRBV12-2+TRBV13-2.51<br>Conclusion: We found no clonal expansion of TCRs or BCRs in elastase-induced AAA in mice at52<br>different disease stages. Our findings imply that a more precise characterization of TCR and BCR53<br>distribution requires a more extensive number of lymphocytes to prevent undersampling and to54<br>potentially detect rare clones. In summary, this paper examines TCR and BCR sequencing results,55<br>identifies limitations and pitfalls, and offers guidance for future studies.</p> <p> </p> <p> </p> <p>The Raw Data can be found here: https://zenodo.org/doi/10.5281/zenodo.10725979</p> <p> </p>
Abdominal Aortic Aneurysm in C57BL/6J Mice - Male and Female PPE vs. Sham Day 7
GEO Series GSE197748. Mus musculus. 19 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
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