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Dataset results
665 results for “Exons”
Post-translational regulation of the exon skipping machinery controls aberrant splicing in T cell leukemia [Jurkat_shSRSF6]
GEO Series GSE139621. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Epigenetically-controlled tumor antigens derived from splice junctions between exons and transposable elements [ChIP-seq]
GEO Series GSE208567. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping
GEO Series GSE292376. Homo sapiens. 6 samples. Type: Other.
Gene structure, differential exon usage, and expression of the testis long intergenic non-protein coding RNA 1016 in humans reveals isoform-specific roles in controlling biological processes
GEO Series GSE171047. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
High-resolution map of copy number variations in motor cortex of Control and Sporadic Amyotrphic Lateral Sclerosis patients by using a customized exon-centric comparative genomic hybridization array.
GEO Series GSE107375. Homo sapiens. 40 samples. Type: Genome variation profiling by array.
Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors
GEO Series GSE60392. Homo sapiens. 17 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Other.
Single nucleus RNA-seq analysis of the TA muscles from WT and Dmd Exon 51 Knockout mice
GEO Series GSE156497. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
The exon junction complex is required for definition and excision of neighboring introns in Drosophila
GEO Series GSE58830. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease — data files
<div>This zenodo entry contains MD and solid-state NMR data files for the paper:</div> <div> </div> <div><strong><em>Mahdi Bagherpoor Helabad et al. (2024) Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease</em></strong></div> <div> </div> <h2> </h2> <h2>MD datasets and code</h2> <div>We provide here (in <strong>MD_simulations_data_codes.zip</strong>) the MD simulations files for the MD runs and also data, and their respective codes, shown in the figures of the above papers.</div> <div> </div> <div>Data file structure: </div> <p><strong>MD_data </strong></p> <ul> <li>The MD simulation run files for three fully periodic systems—PolyQ15 and HTTex1—include the following: .gro files for both minimization and final structures, production .tpr files, force field parameters, GROMACS .mdp files, and position and dihedral restraint files. <ul> <li>fully_periodic_systems</li> <li>polyQ15</li> <li>HTTex1</li> </ul> </li> </ul> <p><strong>Figs_Data_Codes</strong></p> <div> <ul> <li>The data and in-house Python scripts associated with creating the figures: <ul> <li>Fig2B_S4 for Figure 2B and Supplementary Figure 4</li> <li>Fig2D_S5 for Figure 2D and Supplementary Figure 5</li> <li>Fig3C_S10 for Figure 3C and Supplementary Figure 10</li> <li>Fig4_S12_S13_S14 for Figure 4C and Supplementary Figures 12–14</li> <li>Fig6C for Figure 6C</li> <li>FigS3B_S6 for Supplementary Figures 3B and 6</li> <li>FigS8 for Supplementary Figure 8</li> <li>FigS9_S11 for Supplementary Figures 9–11</li> <li>FigS16_to_S21 for Supplementary Figures 16–21</li> <li>FigS22 for Supplementary Figure 22</li> <li>readMe.txt <div> </div> </li> </ul> </li> </ul> </div> <div><strong>Fig6_c_barplot_data.xlsx</strong></div> <div> <ul> <li>Excel file with data plotted in Figure 6C.</li> </ul> <p><strong>N17_SecStr_convergence.xlsx</strong></p> <div> <ul> <li>Excel file with convergence data for N17 domain.</li> </ul> </div> </div> <h2>Solid-state NMR data</h2> <div>We provide here the solid-state NMR spectrum files for the data shown in figures of the above paper.</div> <div> </div> <div>Data file structure:</div> <div> </div> <div><strong>SSNMR_data_listing_20241011a.txt</strong></div> <div> <ul> <li>text file describing the ssNMR data files</li> </ul> </div> <div><strong>SSNMR_data.zip</strong></div> <ul> <li>Figure_1 - data for Figure 1F</li> <li>Figure_5 - data for Figure 5</li> <li>Figure_6 - data for Figure 6</li> <li>Figure_S7 - data for Figure 2G and Supplementary Figure 7</li> <li>Figure_S15 - NMR data for HDX ssNMR of fibrils – Supplementary Figure 15</li> </ul> <div><strong>Fig6_b_barplot_data.xlsx</strong></div> <div> <ul> <li>Excel file with data plotted in Figure 6B, based on previously reported results (DOI 10.1038/ncomms15462)</li> </ul> </div> <div> </div> <div>Data are provided in either Bruker Topspin format, or in NMRPIPE format (ft2 extension).</div> <div>Experimental parameters are described in the published paper and its Supplementary Information files. In general, these are all data from magic-angle-spinning (MAS) NMR studies of intact amyloid fibrils made with isotope labeled HTTex1 fibrils. Experimental types include 2D CP-DARR, 2D TOBSY, 2D HETCOR spectra as well as relaxation measurements. Aside from NMR datafiles, also documents with interpreted and integrated data are included, used to make data curves in the figure (e.g. for Prism software).</div> <div> </div> <div> </div> <div> </div>
A Pan-Asian Clinical Database of EGFR Exon 20 Insertion Mutated NSCLC
ClinicalTrials.gov study NCT06418412. IPD Sharing: NO. Countries: 3. Publications: 0.
Study of PTW-002 in Patients With Dominant or Recessive Dystrophic Epidermolysis Bullosa Due to Mutation(s) in Exon 73 of the COL7A1 Gene
ClinicalTrials.gov study NCT05529134. IPD Sharing: NO. Countries: 1. Publications: 0.
Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer
ClinicalTrials.gov study NCT03727724. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Phase Ib Study of FURMONERTINIB in Patients with NSCLC Having Exon 20 Insertion Mutation
ClinicalTrials.gov study NCT04958967. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping to Evaluate the Safety and Efficacy of ENTR-601-44
ClinicalTrials.gov study NCT07037862. IPD Sharing: NO. Countries: 4. Publications: 0.
Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated
ClinicalTrials.gov study NCT06908993. IPD Sharing: YES. Countries: 1. Publications: 0.
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
ClinicalTrials.gov study NCT03191149. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion
ClinicalTrials.gov study NCT05466149. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of BEBT-109 in Subjects With Non-Small Cell Lung Cancer Carrying EGFR Exon 20 Insertion Mutations
ClinicalTrials.gov study NCT06514027. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 I
ClinicalTrials.gov study NCT05607550. IPD Sharing: UNDECIDED. Countries: 19. Publications: 0.
Study of AOC 1044 in Healthy Adult Volunteers and Participants With Duchenne Muscular Dystrophy (DMD) Mutations Amenable to Exon 44 Skipping
ClinicalTrials.gov study NCT05670730. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.