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447
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ShareScore release 0.7.1
Dataset results
447 results for “Potassium”
Potassium ion homeostasis modulates mitochondrial function II
GEO Series GSE314945. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterium tuberculosis transcriptome on various phases of dormancy in potassium-deficient model
GEO Series GSE66408. Mycobacterium tuberculosis. 12 samples. Type: Expression profiling by high throughput sequencing.
Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development [scRNA-Seq]
GEO Series GSE282936. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA serves as direct thermo and potassium sensors via spliceswitch formed by G-quadruplex in mammals
GEO Series GSE262498. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Nucleotide-resolution, genome-wide transcriptome maps of Propionibacterium acnes (cultured with and without potassium downshift)
GEO Series GSE46883. Cutibacterium acnes KPA171202. 2 samples. Type: Expression profiling by high throughput sequencing.
A global transcription study of the regulatory effects of potassium, glutamate and c-di-AMP in Bacillus subtilis
GEO Series GSE156738. Bacillus subtilis subsp. subtilis str. 168. 12 samples. Type: Expression profiling by array.
Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite Against Pseudomonas aeruginosa
GEO Series GSE232832. Pseudomonas aeruginosa. 12 samples. Type: Expression profiling by high throughput sequencing.
A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma
GEO Series GSE231577. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
KCNQ POTASSIUM CHANNELS MODULATE WNT ACTIVITY IN GASTRO-OESOPHAGEAL ADENOCARCINOMAS
GEO Series GSE242782. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Potassium ion homeostasis modulates mitochondrial function I
GEO Series GSE314779. Saccharomyces cerevisiae. 6 samples. Type: Expression profiling by high throughput sequencing.
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.
GEO Series GSE260669. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Bespoke strategies of Paxillus involutus to extract potassium from diverse phyllosilicates
GEO Series GSE158973. Paxillus involutus. 25 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide screening of HNF1b binding sites identifies transcriptional regulation of the Kir4.1/Kir5.1 potassium channel
GEO Series GSE77397. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of potassium and chloride channels in eccrine sweat glands
GEO Series GSE73715. Mus musculus. 20 samples. Type: Expression profiling by array.
Effect of the Mbov_0496 mutation on gene expression of Mycoplasma bovis under normal and high potassium conditions
GEO Series GSE282920. Mycoplasmopsis bovis. 12 samples. Type: Expression profiling by high throughput sequencing.
Formation of Friable Embryogenic Callus is Enhanced under Nitrate, Potassium and Phosphate Limited Condition in Cassava.
GEO Series GSE89971. Manihot esculenta. 8 samples. Type: Expression profiling by array.
Diversely evolved xibalbin variants from remipede venom inhibit 3 potassium channels and activate PKA-II and Erk1/2 signalling
<p><span><strong>Background:</strong> </span><span>The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede <em>Xibalbanus tulumensis</em>, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.</span></p> <p><strong><span>Result:</span></strong><span><strong> </strong>Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib<sub>1</sub> and xib<sub>13</sub>, with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing we demonstrate that xib<sub>1</sub> and xib<sub>13</sub> increase PKA-II and Erk1/2 sensitization signaling in nociceptive neurons, which may initiate pain sensitization. Our phylogenetic analysis suggests that xib<sub>13</sub> either originates from the common ancestor of pancrustaceans or earlier while xib<sub>1</sub> is more restricted to remipedes. The ten-cysteine scaffolded xib<sub>2</sub> emerged from xib<sub>1</sub>, a result that is supported by our phylogenetic and machine learning-based analyses.</span></p> <p><strong><span>Conclusions</span></strong><span><strong>: </strong>Our functional characterization of synthesized variants of xib<sub>1</sub>, xib<sub>2</sub>, and xib<sub>13</sub> elucidates their potential as inhibitors of potassium channels in mammalian systems. The specific interaction of xib<sub>2</sub> with Kv1.6 channels, which are relevant to treating variants of epilepsy, shows potential for further studies. At higher concentrations, xib1 and xib13 activate the kinases PKA-II and ERK1/2 in mammalian sensory neurons, suggesting pain sensitization and potential applications related to pain research and therapy. While tested insect channels suggest that all probably act as neurotoxins, the biological function of xib<sub>1</sub>, xib<sub>2,</sub> and xib<sub>13</sub> requires further elucidation. A novel finding on their evolutionary origin is the apparent emergence of </span><em><span>X. tulumensis</span></em><span>-specific xib<sub>2</sub> from xib<sub>1</sub>. Our study is an important cornerstone for future studies to untangle the origin and function of these enigmatic proteins as important components of remipede but also other pancrustacean and arthropod venoms.</span></p>
alignment of potassium channels sequences
<p>This aligment (MAFFT) was used to perform a phylogenetic analysis (PhyML) to determine the position of the potassium channel sequences of Oopsacas minuta.</p>
Low Potassium Content Vegetables in End-Stage Renal Disease
ClinicalTrials.gov study NCT04182438. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Potassium (K) and Ionized Calcium (iCa) Tests Using Capillary Specimens
ClinicalTrials.gov study NCT07287618. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.