Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
273
datasets available to search
ShareScore release 0.9.0
Dataset results
273 results for “cerebral cortex”
Spaceflight-Induced Gene Expression Profiles in the Mouse Brain Are Attenuated by Treatment with the Antioxidant BuOE - Cerebral Cortex
The demands of deep space pose a health risk to the central nervous system that has long been a concern when sending humans to space. While little is known about how spaceflight affects transcription spatially in the brain, a greater understanding of this process has the potential to aid strategies that mitigate the effects of spaceflight on the brain. Therefore, we performed GeoMx Digital Spatial Profiling of mouse brains subjected to either spaceflight or grounded controls. Four brain regions were selected: Cortex, Frontal Cortex, Corunu Ammonis I, and Dentate Gyrus. Antioxidants have emerged as a potential means of attenuating the effects of spaceflight, so we treated a subset of the mice with a superoxide dismutase mimic, MnTnBuOE-2-PyP 5+ (BuOE). Our analysis revealed hundreds of differentially expressed genes due to spaceflight in each of the four brain regions. Both common and region-specific transcriptomic responses were observed. Metabolic pathways and pathways sensitive to oxidative stress were enriched in the four brain regions due to spaceflight. These findings enhance our understanding of brain regional variation in susceptibility to spaceflight conditions. BuOE reduced the transcriptomic effects of spaceflight at a large number of genes, suggesting that this compound may attenuate oxidative stress-induced brain damage caused by the spaceflight environment. This study contains data of cerebral cortex region. The data of other brain regions are deposited in OSD-682 (cornu ammonis 1), OSD-685 (dentate gyrus), and OSD-698 (frontal cortex).
Gene expression in the mouse cerebral cortex exposed to Bisphenol A (BPA) during development.
GEO Series GSE53158. Mus musculus. 12 samples. Type: Expression profiling by array.
Transcriptional profiling of pyramidal neurons in the cerebral cortex of Glt25d2-TRAP (DU9) mice administered either saline or cocaine [TRAP-seq]
GEO Series GSE141337. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell Transcriptomes of Cerebral Cortex in Embryonic 18 Days
GEO Series GSE123035. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of neurons in the cerebral cortex of S100a10-TRAP (ES691) mice administered either saline or cocaine
GEO Series GSE141464. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive analysis of circRNA expression profiles in rat cerebral cortex after moderate traumatic brain injury
GEO Series GSE193521. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of mRNAs in cortex of rats with cerebral ischemia and reperfusion
GEO Series GSE222704. Rattus norvegicus. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of pericytes in the cerebral cortex of a Gdnf-TRAP (ES2243) mouse line
GEO Series GSE142133. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Gene expression file at single cell level of nerve cells in damaged areas of the cerebral cortex in mice with traumatic brain injury
GEO Series GSE276065. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Sequential regulation of glutamatergic and subtype-specific projection neuron identities in the developing cerebral cortex
GEO Series GSE142269. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq of mouse cells from the dorsal cerebral cortex during its formation, with knocked-out Ski gene
GEO Series GSE134690. Mus musculus. 63 samples. Type: Expression profiling by high throughput sequencing.
The CAP1 represses MRTF-SRF–dependent gene expression in the mouse cerebral cortex by an actin-dependent mechanism
GEO Series GSE262154. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in Tbr2 lineage neurons in the murine cerebral cortex
GEO Series GSE121470. Mus musculus. 27 samples. Type: Expression profiling by array.
Effects of repetitive hypobaric hypoxia exposure on the transcriptomic profiles of cerebral cortex and hippocampus in rats
GEO Series GSE313136. Rattus norvegicus. 21 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of interneurons in the cerebral cortex of Htr3a-Cre (NO176) mice
GEO Series GSE141874. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of neurons in the cerebral cortex of a Cbln1-TRAP (NIDA030) mouse line
GEO Series GSE141339. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Quantitative Analysis of Cerebral Cortex Transcriptomes of BrapcKO Mice and their Wildtype-like Control Mice by Next-Generation Sequencing
GEO Series GSE183383. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Sequential transcriptomic alterations in the cerebral cortex of mice after cerebral venous sinus thrombosis
GEO Series GSE245455. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of neurons in the cerebral cortex of a Kcnip2-TRAP (NIDA115) mouse line
GEO Series GSE141898. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of pyramidal neurons in the cerebral cortex of a Htr4-TRAP (ES1299) mouse line
GEO Series GSE141921. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.