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397
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ShareScore release 0.9.0
Dataset results
397 results for “functional interactions”
Functional interactions between Mi-2β and AP1 complexes control response and recovery from barrier disruption
GEO Series GSE139685. Homo sapiens; Mus musculus. 53 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution [ChIP-seq]
GEO Series GSE59942. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
1) Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts & 2) Epidermal ABHD12B-driven atypical acylceramide safeguards
GEO Series GSE262558. Mus musculus. 4 samples. Type: Other.
Data from: Coevolution-based inference of amino acid interactions underlying protein function
Protein function arises from a poorly understood pattern of energetic interactions between amino acid residues. Sequence-based strategies for deducing this pattern have been proposed, but lack of benchmark data has limited experimental verification. Here, we extend deep-mutation technologies to enable measurement of many thousands of pairwise amino acid couplings in several homologs of a protein family – a deep coupling scan (DCS). The data show that cooperative interactions between residues are loaded in a sparse, evolutionarily conserved, spatially contiguous network of amino acids. The pattern of amino acid coupling is quantitatively captured in the coevolution of amino acid positions, especially as indicated by the statistical coupling analysis (SCA), providing experimental confirmation of the key tenets of this method. This work exposes the collective nature of physical constraints on protein function and clarifies its link with sequence analysis, enabling a general practical approach for understanding the structural basis for protein function.
Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation
<p><strong>Data for "Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation"</strong></p> <p><strong>Data directories</strong></p> <ul> <li>bulk-1week</li> </ul> <p>Contains processed bulk TCR sequencing data from cohort 1.</p> <ul> <li>longitudinal</li> </ul> <p>Contains processed bulk TCR sequencing data from cohort 2.<br>Note that this is the same dataset as reported in the following reference (it is included again in this repository for completeness):<br>B. Ogunjimi, J. Van den Bergh, P. Meysman, S. Heynderickx, K. Bergs, H. Jansens, E. Leuridan, A. Vorsters, H. Goossens, K. Laukens, N. Cools, V. Van Tendeloo, N. Hens, P. Van Damme, E. Smits, P. Beutels, Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox. Sci Rep 7, 1077 (2017).</p> <ul> <li>single-cell</li> </ul> <p>Contains processed single cell data from cohort 1.</p> <ul> <li>stim</li> </ul> <p>Contains TCR data from stimulation experiments.</p> <p><strong>Script directories</strong></p> <ul> <li>src</li> </ul> <p>Contains various scripts used to generate the results and figures in the manuscript.</p> <p><strong>Result directories</strong></p> <ul> <li>results</li> </ul> <p>Contains the inbetween files for many of the analyses.<br>Contains the Seurat object for the single cell analysis reported in the paper.<br>Also used as output directory for the scripts listed in src.</p> <ul> <li>tcrex_results</li> </ul> <p>Full results from using the aforementioned data sets with the TCRex tool:<br>https://tcrex.biodatamining.be/</p>
Digital Interactive Technologies in Rehabilitation of Post-sroke Patients With Impaired Fine Function of the Hand
ClinicalTrials.gov study NCT05214521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Examination of Cardiovascular Function/ Cardio Respiratory Interaction on Spontaneous Breathing Trials in Patients in the Prolonged Weaning
ClinicalTrials.gov study NCT02569385. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury
ClinicalTrials.gov study NCT01537978. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction in Adolescents
ClinicalTrials.gov study NCT05357053. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prosthetic Smart Socket Technology to Improve Patient Interaction, Usability, Comfort, Fit, and Function.
ClinicalTrials.gov study NCT03199222. IPD Sharing: NO. Countries: 1. Publications: 0.
Nivolumab in mRCC Patients: Treg Function, T-cell Access and NK Interactions to Predict and Improve Efficacy
ClinicalTrials.gov study NCT03891485. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
ClinicalTrials.gov study NCT06335836. IPD Sharing: Not stated. Countries: 1. Publications: 0.
e-Unstuck:Interactive e-Learning Software for Parents to Support Executive Functioning and Behavior Regulation in Children With Autism Spectrum Disorder
ClinicalTrials.gov study NCT02708069. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Interactive Stepping Exercise on Balance and Cognitive Function
ClinicalTrials.gov study NCT04494906. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function
ClinicalTrials.gov study NCT06682481. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
ClinicalTrials.gov study NCT03486249. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Functional Muscle Characteristics and Cardio-respiratory Interaction in Patients With Fontan Palliation
ClinicalTrials.gov study NCT04151004. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Social Cognition and Interaction Training for Improving Social Functioning in People With Schizophrenia
ClinicalTrials.gov study NCT00601224. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
ClinicalTrials.gov study NCT06275399. IPD Sharing: NO. Countries: 1. Publications: 0.
A Scalable Model for Promoting Functioning and Well-Being Among Veterans With a History of Mental Health Challenges Via Meaningful Social Interactions: Project V-SPEAK!
ClinicalTrials.gov study NCT05506839. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.