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ShareScore release 0.9.0
Dataset results
245 results for “tibia”
Multiregion BHA in Open Tibia Fractures
ClinicalTrials.gov study NCT04056429. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Tibia - pQCT)
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of complete unloading. More recently, the effects of partial unloading on the musculoskeletal system have been interrogated in mice and rats, revealing dose-dependent effects of partial weight bearing (PWB) on the skeleton and skeletal muscle. Here, we extended these studies to determine the structural and functional skeletal alterations in 14-week-old male Wister rats exposed to 20%, 40%, 70%, or 100% of body weight for 1, 2, or 4 weeks (n equals 11–12/group). Using in vivo pQCT, we found that trabecular bone density at the proximal tibia declined in proportion to the degree of unloading and continued progressively with time, without evidence of a plateau by 4 weeks. Ex vivo measurements of trabecular microarchitecture in the distal femur by microcomputed tomography revealed deficits in bone volume fraction, 2 and 4 weeks after unloading. Histologic analyses of trabecular bone in the distal femur revealed the decreased osteoblast number and mineralizing surface in unloaded rats. Three-point bending of the femoral diaphysis indicated modest or no reductions in femoral stiffness and estimated modulus due to PWB. Our results suggest that this rat model of PWB leads to trabecular bone deterioration that is progressive and generally proportional to the degree of PWB, with minimal effects on cortical bone. This study derives results from the pQCT assay using tibia tissue.
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Tibia; pQCT)
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle strength in micro- and partial-gravity environments (e.g., the Moon or Mars) is not fully understood. The purpose of this study was to determine the influence of gonadectomy (castration/ovariectomy) on progression of muscle atrophy in both micro- and partial-gravity environments in male and female rats. Male and female Fischer rats (n equals 120) underwent castration/ovariectomy (CAST/OVX) or sham surgery (SHAM) at 11 weeks of age. After 2 weeks of recovery, rats were exposed to hindlimb unloading (0g), partial weight bearing at 40% of normal loading (0.4g, Martian gravity), or normal loading (1.0g) for 28 days. In males, CAST did not exacerbate body weight loss or other metrics of musculoskeletal health. In females, OVX animals tended to have greater body weight loss and greater gastrocnemius loss. Within 7 days of exposure to either microgravity or partial gravity, females had detectable changes to estrous cycle, with greater time spent in low-estradiol phases diestrus and metestrus (∼47% in 1g vs. 58% in 0g and 72% in 0.4g animals, P equals 0.005). We conclude that in males testosterone deficiency at the initiation of unloading has little effect on the trajectory of muscle loss. In females, initial low estradiol status may result in greater musculoskeletal losses. This study derives results from pQCT (Peripheral quantitative computed tomography).
The osteogenic capacity and lncRNA/mRNA expression profile of periosteal-derived mesenchymal stem cells of congenital pseudarthrosis of the tibia
GEO Series GSE200069. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Gene expression profile at single cell level of Gli1+ progenitors from the metaphysis of distal femur and proximal tibia in response to MPS.
GEO Series GSE248553. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
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OpenNeuro
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