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255
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ShareScore release 0.9.0
Dataset results
255 results for “tumor associated macrophages;”
Expression of Adipocyte/Macrophage Fatty Acid Binding Protein in Tumor Associated Macrophages Promotes Breast Cancer Progression
GEO Series GSE109703. Mus musculus; synthetic construct. 6 samples. Type: Non-coding RNA profiling by array.
Expression data from vehicle tumor associated macrophages (TAM) VS PLX3397 treated-TAM.
GEO Series GSE95406. Mus musculus. 6 samples. Type: Expression profiling by array.
Whole-course Taming of Tumor-associated Macrophages from Central to Peripheral using Engineered Outer Membrane Vesicle Nanohybrids for Improved Immunotherapy [part 2: ATAC-seq]
GEO Series GSE212260. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Exogenous and endogenous serine modulate polarization of tumor-associated macrophages to influence development of nasopharyngeal carcinoma
GEO Series GSE263382. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Tumor progression is independent of tumor associated macrophages in two lineage-based mouse models of GBM
GEO Series GSE226051. Mus musculus. 41 samples. Type: Expression profiling by high throughput sequencing.
Endocytic and signalling function of stabilin-1 in tumor associated macrophages
GEO Series GSE55595. Mus musculus. 6 samples. Type: Expression profiling by array.
Lymphatic-derived 25-hydroxycholesterol promotes immunity in melanoma by inhibiting PPAR-γ in tumor associated macrophages and monocytes
GEO Series GSE242150. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
WDR4 Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression via eIF4E-Mediated mRNA Translation
GEO Series GSE301487. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Treg cell by tumor-associated macrophage ROS and inflammatory signaling through T-cell NF-κB c-Rel drives pathogenesis of lung adenocarcinomas
GEO Series GSE132460. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "
<p>This record contains raw data related to article “Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity"</p> <p><strong>Background: </strong> Tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer and hinder the antitumoral efficacy of most treatments currently applied in the clinic. Previous studies have evaluated the antitumoral immune response triggered by (TLR) agonists, such as poly(I:C), imiquimod (R837) or resiquimod (R848) as monotherapies; however, their combination for the treatment of cancer has not been explored. This study investigates the antitumoral efficacy and the macrophage reprogramming triggered by poly(I:C) combined with R848 or with R837, versus single treatments.</p> <p><strong>Methods: </strong> TLR agonist treatments were evaluated in vitro for toxicity and immunostimulatory activity by Alamar Blue, ELISA and flow cytometry using primary human and murine M-CSF-differentiated macrophages. Cytotoxic activity of TLR-treated macrophages toward cancer cells was evaluated with an in vitro functional assay by flow cytometry. For in vivo experiments, the CMT167 lung cancer model and the MN/MCA1 fibrosarcoma model metastasizing to lungs were used; tumor-infiltrating leukocytes were evaluated by flow cytometry, RT-qPCR, multispectral immunophenotyping, quantitative proteomic experiments, and protein-protein interaction analysis.</p> <p><strong>Results: </strong> Results demonstrated the higher efficacy of poly(I:C) combined with R848 versus single treatments or combined with R837 to polarize macrophages toward M1-like antitumor effectors in vitro. In vivo, the intratumoral synergistic combination of poly(I:C)+R848 significantly prevented tumor growth and metastasis in lung cancer and fibrosarcoma immunocompetent murine models. Regressing tumors showed increased infiltration of macrophages with a higher M1:M2 ratio, recruitment of CD4<sup>+</sup> and CD8<sup>+</sup> T cells, accompanied by a reduction of immunosuppressive CD206<sup>+</sup> TAMs and FOXP3<sup>+</sup>/CD4<sup>+</sup> T cells. The depletion of both CD4<sup>+</sup> and CD8<sup>+</sup> T cells resulted in complete loss of treatment efficacy. Treated mice acquired systemic antitumoral response and resistance to tumor rechallenge mediated by boosted macrophage cytotoxic activity and T-cell proliferation. Proteomic experiments validate the superior activation of innate immunity by poly(I:C)+R848 combination versus single treatments or poly(I:C)+R837, and protein-protein-interaction network analysis reveal the key activation of the STAT1 pathway.</p> <p><strong>Discussion: </strong> These findings demonstrate the antitumor immune responses mediated by macrophage activation on local administration of poly(I:C)+R848 combination and support the intratumoral application of this therapy to patients with solid tumors in the clinic.</p>
Dataset related to article "Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer"
<p>This record contains raw data related to article “Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer"</p> <p>Abstract</p> <p>Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used to profile the transcriptional landscape of TAMs in human PCa, leading to identification of a subset of macrophages characterized by dysregulation in transcriptional pathways associated with lipid metabolism. This subset of TAMs correlates positively with PCa progression and shorter disease-free survival and is characterized by an accumulation of lipids that is dependent on Marco. Mechanistically, cancer cell-derived IL-1β enhances Marco expression on macrophages, and reciprocally, cancer cell migration is promoted by CCL6 released by lipid-loaded TAMs. Moreover, administration of a high-fat diet to tumor-bearing mice raises the abundance of lipid-loaded TAMs. Finally, targeting lipid accumulation by Marco blockade hinders tumor growth and invasiveness and improves the efficacy of chemotherapy in models of PCa, pointing to combinatorial strategies that may influence patient outcomes.</p>
Annexin-A1-mediated regulation of the efferocytosis in tumor-associated macrophage promotes anti-tumor immune response by activating the cGAS/STING pathway in pancreatic cancer
GEO Series GSE255146. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
S100A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma
GEO Series GSE158792. Homo sapiens. 4 samples. Type: Expression profiling by array.
Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
<p>This record contains raw data related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"</p><p> </p><p><strong>Rationale:</strong> Nanobodies (Nbs) have emerged as an elegant alternative to the use of conventional monoclonal antibodies in cancer therapy, but a detailed microscopic insight into the <i>in vivo</i> pharmacokinetics of different Nb formats in tumor-bearers is lacking. This is especially relevant for the recognition and targeting of pro-tumoral tumor-associated macrophages (TAMs), which may be located in less penetrable tumor regions. <strong>Methods:</strong> We employed anti-Macrophage Mannose Receptor (MMR) Nbs, in a monovalent (m) or bivalent (biv) format, to assess <i>in vivo</i> TAM targeting. Intravital and confocal microscopy were used to analyse the blood clearance rate and targeting kinetics of anti-MMR Nbs in tumor tissue, healthy muscle tissue and liver. Fluorescence Molecular Tomography was applied to confirm anti-MMR Nb accumulation in the primary tumor and in metastatic lesions. <strong>Results:</strong> Intravital microscopy demonstrated significant differences in the blood clearance rate and macrophage targeting kinetics of (m) and (biv)anti-MMR Nbs, both in tumoral and extra-tumoral tissue. Importantly, (m)anti-MMR Nbs are superior in reaching tissue macrophages, an advantage that is especially prominent in tumor tissue. The administration of a molar excess of unlabelled (biv)anti-MMR Nbs increased the (m)anti-MMR Nb bioavailability and impacted on its macrophage targeting kinetics, preventing their accumulation in extra-tumoral tissue (especially in the liver) but only partially influencing their interaction with TAMs. Finally, anti-MMR Nb administration not only allowed the visualization of TAMs in primary tumors, but also at a distant metastatic site. <strong>Conclusions:</strong> These data describe, for the first time, a microscopic analysis of (m) and (biv)anti-MMR Nb pharmacokinetics in tumor and healthy tissues. The concepts proposed in this study provide important knowledge for the future use of Nbs as diagnostic and therapeutic agents, especially for the targeting of tumor-infiltrating immune cells</p>
DATESET RELATED TO ARTICLE "b2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression"
<p>RAW DATA RELATED TO ARTICLE AT TITLE</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.