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2,800 results for “CD8+ T cells”
Dataset related to the article "Single- cell profiling defines the prognostic benefit of CD39hi tissue resident memory CD8+ T cells in lumina-like breast cancer"
<p>This record contains data related to the article " Single- cell profiling defines the prognostic benefit of CD39hi tissue resident memory CD8+ T cells in lumina-like breast cancer ".</p> <p>Luminal-like breast cancer (BC) constitutes the majority of BC subtypes, but, differently from highly aggressive triple negative BC, is poorly infiltrated by the immune system. The quality of the immune infiltrate in luminal-like BCs has been poorly studied, thereby limiting further investigation of immunotherapeutic strategies. By using high-dimensional single-cell technologies, we identify heterogeneous behavior within the tissue-resident memory CD8+ T (Trm) cells infiltrating luminal-like tumors. A subset of CD127- CD39<sup>hi</sup> Trm cells, preferentially present in the tumor compared to the adjacent normal breast tissue or peripheral blood, retains enhanced degranulation capacity compared to the CD127+ CD39<sup>lo</sup> Trm counterpart ex vivo, and is specifically associated with positive prognosis. Nevertheless, such prognostic benefit is lost in the presence of highly-suppressive CCR8<sup>hi</sup> ICOS<sup>hi</sup> IRF4+ effector Tregs. Thus, combinatorial strategies aiming at boosting Trm function and infiltration while relieving from Treg-mediated immunosuppression should be investigated to achieve proper tumor control in luminal-like BCs.</p> <p> </p>
Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling
<p>SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants. We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8+ T cell response to SARS-CoV-2 infection at high resolution and compared responses between mild and severe COVID-19. We observed a population of exhausted CD8+ T cells in severe SARS-CoV-2 infection and identified a population of NK-like, terminally differentiated CD8+ effector T cells characterized by expression of FCGR3A (encoding CD16). Further characterization of NK-like CD8+ T cells revealed heterogeneity among CD16+ NK-like CD8+ T cells and profound differences in cytotoxicity, exhaustion, and NK-like differentiation between mild and severe disease conditions. We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8+ effector T cells, ultimately resulting in the appearance of NK-like CD8+ T cell populations of different functionality and pathogenicity. Our in-depth characterization of the CD8+ T cell-mediated response to SARS-CoV-2 infection provides a basis for further investigation of the importance of NK-like CD8+ T cells in COVID-19 severity.</p>
LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
<p>Additional data</p>
Dataset related to article "High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors"
<p>This record contains raw data related to article "High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors"</p> <p>CD8<sup>+</sup> T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8<sup>+</sup> T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors compared with cancer-free tissues and blood. Besides exhausted and activated cells, we identified CXCR5<sup>+</sup> TIM-3<sup>-</sup> CD8<sup>+</sup> T cells with a partial exhausted phenotype, while retaining gene networks responsible for stem-like plasticity and cytotoxicity, as revealed by single cell sequencing of the whole transcriptome. Ex vivo, CXCR5<sup>+</sup> TIM-3<sup>-</sup> CD8<sup>+</sup> T cells displayed enhanced self-renewal and multipotency compared with more differentiated subsets and were largely polyfunctional. Analysis of inhibitory and costimulatory receptors revealed PD-1, TIGIT, and CD27 as possible targets of immunotherapy. We thus demonstrate a hierarchy of differentiation in the context of T cell exhaustion in human cancer similar to that of chronically infected mice, which is further shown to disappear with disease progression.</p>
LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
<p>Code and data for review of manuscript</p>
Osr2 functions as a mechanical checkpoint to augment CD8+ T cell exhaustion [TIL_scRNA_CD8]
GEO Series GSE223160. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
T-bet Suppresses TGF-b-independent Gut-resident Memory CD8+ T Cell Differentiation.
GEO Series GSE184629. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to govern anti-tumor immunity
GEO Series GSE254597. Mus musculus. 8 samples. Type: Other.
Bulk RNA-seq analysis of Exhausted CD8 T cell subsets
GEO Series GSE145910. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment (RNA-Seq)
GEO Series GSE266287. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
GEO Series GSE173515. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity [RNA-seq]
GEO Series GSE228886. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression patterns of tumor-infiltrating CD8 T cells according to the CD137 expression in human metastatic ovarian cancer
GEO Series GSE150301. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells
GEO Series GSE215762. Mus musculus. 41 samples. Type: Expression profiling by high throughput sequencing; Other.
Expression Profile of alloreactive CD8 and CD4 induced regulatory T cells
GEO Series GSE75118. Mus musculus. 12 samples. Type: Expression profiling by array.
3D genome of CD8+ T cells reveals IRF8-mediated exhaustion in cancer [Hi-C]
GEO Series GSE299305. Mus musculus. 4 samples. Type: Other.
PD-1-PD-L1 Axis Activation Suppresses CD8+ T Cells and Improves Nephritis.
GEO Series GSE228813. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Neonatal CD8+ T cells resist terminal exhaustion during chronic infection
GEO Series GSE234309. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from rhesus macaque blood CD8+ T cells
GEO Series GSE61766. Macaca mulatta. 33 samples. Type: Expression profiling by array.
Zinc Finger and BTB Domain Containing 32 (Zbtb32) transcription factor promotes CD8+ T cell differentiation and function in cancer [ChIP-Seq]
GEO Series GSE284605. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.