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1,088
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Dataset results
1,088 results for “Cardiomyopathy”
Investigation in Pregnancy Associate Cardiomyopathy
ClinicalTrials.gov study NCT01085955. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study
ClinicalTrials.gov study NCT04425785. IPD Sharing: NO. Countries: 1. Publications: 35.
Bromocriptine in the Treatment of Peripartum Cardiomyopathy
ClinicalTrials.gov study NCT02590601. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy
ClinicalTrials.gov study NCT06253221. IPD Sharing: YES. Countries: 9. Publications: 1.
A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy
ClinicalTrials.gov study NCT02915718. IPD Sharing: YES. Countries: 1. Publications: 2.
Association of Obesity and Cardiovascular Outcomes in Dilated Cardiomyopathy
ClinicalTrials.gov study NCT05645952. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: The demanding grey zone: sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete's heart
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Repolarization and contractility in hypertrophic cardiomyopathy patients
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Supplementary Data for Publication Titled "Sex differences in regulating the cardiac transcriptome within a murine model for hypertrophic cardiomyopathy"
<p>Supplementary data for publication titled "Sex differences in regulating the cardiac transcriptome within a murine model for hypertrophic cardiomyopathy".</p>
Dataset related to the article "Arrhythmogenic cardiomyopathy: what blood can reveal?"
<p>This record contains raw data related to the article “Arrhythmogenic cardiomyopathy: what blood can reveal?”</p> <p>Blood, serum and plasma represent accessible sources of data about physiological and pathologic status. In arrhythmogenic cardiomyopathy (ACM), circulating nucleated cells are routinely used for detection of germinal genetic mutations. In addition, different biomarkers have been proposed for diagnostic purposes and for monitoring disease progression, including inflammatory cytokines, markers of myocardial dysfunction and damage, and microRNAs. This review summarizes the current information that can be retrieved from the blood of ACM patients and considers the future prospects. Improvements in current knowledge of circulating factors may provide noninvasive means to simplify and improve the diagnosis, prognosis prediction, and management of ACM patients.</p>
Data from: High reproducibility of adenosine stress cardiac magnetic resonance myocardial perfusion imaging in patients with nonischemic dilated cardiomyopathy
Objective: To evaluate the reproducibility of first-pass contrast-enhanced cardiac MR (CMR) myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy (NIDCM). Design: Prospective observational study. Setting: Single centre, tertiary care hospital. Participants: 6 outpatient participants with NIDCM. Outcome: Reproducibility of semiquantitative myocardial perfusion analysis by CMR. Method: 6 patients with NIDCM were studied twice using first-pass of contrast transit through the left ventricular (LV) myocardium with a saturation-recovery gradient echo sequence at rest and during adenosine-induced hyperaemia. The anterior wall was divided into endocardial (Endo) and epicardial (Epi) segments. The Myocardial Perfusion Index (MPI) was calculated as the myocardial signal augmentation rate normalised to the LV cavity rate. The Myocardial Perfusion Reserve Index (MPRI) was calculated as hyperaemic/resting MPI. Results: Between study 1 and 2, median MPI was similar for resting Endo (0.076 vs 0.077), hyperaemic Endo (0.143 vs 0.143), resting Epi (0.073 vs 0.074), and hyperaemic Epi (0.135 vs 0.134). Median MPRI was similar for Endo (1.84 vs 1.87) and Epi (1.90 vs 2.00). Combining Endo and Epi MPI (N=12), there was excellent agreement between Study 1 and 2 for resting MPI (r=0.998, intraclass correlation coefficient (ICC) 0.998, coefficients of variation (CoV) 1.4%), hyperaemic MPI (r=0.979, ICC 0.963, CoV 3.3%) and MPRI (r=0.989, ICC 0.94, CoV 3.8%). Conclusions: Resting and hyperaemic myocardial perfusion using a normalised upslope analysis during adenosine CMR is a highly reproducible technique in patients with NIDCM. Trial registration number: Clinical Trials.Gov ID NCT00574119.
Supplementary Data forExploring Potential Druggable Gene Targets for Hypertrophic Cardiomyopathy through Mendelian Randomization
<p><em>该数据集包含探索肥厚型心肌病可成药基因靶点的手稿的补充材料</em>。</p>
Dataset from a randomised cross-over trial of QT response to hyperventilation-induced anxiety and diaphragmatic breathing in patients with stress cardiomyopathy and in control patients
<p>Dataset from a randomised cross-over trial that compared the QT response to hyperventilation-induced anxiety and diaphragmatic breathing in patients with stress cardiomyopathy and age- and sex-matched controls. Pre-registered in the Australia and New Zealand Clinical Trials Registry (ACTRN12618001812280).</p>
Searching for the relationship between the presence, extent, location and 12-month dynamics of cardiac fibrosis and the genetic profile in patients with dilated cardiomyopathy - a pilot study
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Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
<p>Abstract. The healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopathy. A principal regulator of cardiac metabolism is 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2), which is a central driver of glycolysis. We hypothesized that increasing PFK-2 activity could mitigate cardiac dysfunction induced by high fat diet (HFD). Wild type (WT) and cardiac-specific transgenic mice expressing PFK-2 (Glyco<sup>Hi</sup>) were fed a low fat or HFD for 16-weeks to induce metabolic dysfunction. Metabolic phenotypes were determined by measuring mitochondrial bioenergetics and performing targeted quantitative proteomic and metabolomic analysis. Increasing cardiac PFK-2 had beneficial effects on cardiac and mitochondrial function. Unexpectedly, Glyco<sup>Hi</sup> mice also exhibited sex-dependent systemic protection from HFD, including increased glucose homeostasis. These findings support improving glycolysis via PFK-2 activity can mitigate mitochondrial and functional changes that occur with metabolic syndrome.</p> <p>There are two types of data in this upload, proteomics and metabolomics.</p> <p>The proteomics data are raw files acquired on a tsq quantiva triple quadrupole mass spectrometer in the SRM mode at OMRF. Each file is panel of protein assays. Please contact Mike Kinter with questions.</p> <p>The metabolomics data are more processed data files as described in the paper. Please contact Haiwei Gu with questions.</p>
Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG
ClinicalTrials.gov study NCT01432626. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
ClinicalTrials.gov study NCT05556343. IPD Sharing: YES. Countries: 4. Publications: 0.
Zinc Deficiency in Dilated Cardiomyopathy
ClinicalTrials.gov study NCT04860921. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Halt cardiomyOPathy progrEssion in Duchenne (HOPE-OLE)
ClinicalTrials.gov study NCT06304064. IPD Sharing: NO. Countries: 1. Publications: 0.
Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy
ClinicalTrials.gov study NCT02115581. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.