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648
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ShareScore release 0.9.0
Dataset results
648 results for “Helicobacter pylori”
Effect of Helicobacter pylori on ATM-dependent DNA damage responses [cell lines]
GEO Series GSE60661. Homo sapiens. 8 samples. Type: Expression profiling by array.
Toll-like receptor 10 in Helicobacter pylori infection
GEO Series GSE60427. Homo sapiens. 32 samples. Type: Expression profiling by array.
Global transcriptome analysis of macrophages during Helicobacter pylori infection
GEO Series GSE67270. Mus musculus. 69 samples. Type: Expression profiling by high throughput sequencing.
Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis
GEO Series GSE271866. Mus musculus; Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Effect of Helicobacter pylori on ATM-dependent DNA damage responses
GEO Series GSE47797. Homo sapiens. 24 samples. Type: Expression profiling by array.
The role of TRAF1 in Helicobacter pylori infection
GEO Series GSE290844. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The expression of miRNAs is influenced by the infection of Helicobacter Pylori
GEO Series GSE98641. Homo sapiens. 16 samples. Type: Non-coding RNA profiling by array.
CagA-specific gastric CD8+ tissue-resident T cells control Helicobacter pylori during the early infection phase
GEO Series GSE216894. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Chronic inflammation is a risk factor for gastric carcinogenesis after Helicobacter pylori eradication [RNA-seq]
GEO Series GSE190449. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Helicobacter pylori-mediated Epigenetic Dysregulation of FOXD3 Tumor-suppressive Cascade In Gastric Carcinogenesis
GEO Series GSE39600. Homo sapiens; Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array.
Helicobacter pylori pathogenic mechanism
GEO Series GSE30042. Homo sapiens. 3 samples. Type: Expression profiling by array.
Effect of Helicobacter pylori on ATM-dependent DNA damage responses [biopsy]
GEO Series GSE60662. Homo sapiens. 16 samples. Type: Expression profiling by array.
Transcriptome profiling of m6A mRNA modification in GES-1 cells infected by Helicobacter pylori
GEO Series GSE230869. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via AKT-related pathway
GEO Series GSE267263. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Lactobacillus acidophilus and Helicobacter pylori stimulation of bone marrow derived macrophage
GEO Series GSE42622. Mus musculus. 12 samples. Type: Expression profiling by array.
Transcriptomic remodeling of gastric cells by Helicobacter pylori Outer Membrane Vesicles
GEO Series GSE229512. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analyses of gene expression in Helicobacter pylori CrdRS two-component system deletion strains
GEO Series GSE221309. Helicobacter pylori 26695. 6 samples. Type: Expression profiling by high throughput sequencing.
Assessment of real-time PCR for Helicobacter pylori DNA detection in stool with co-infection of intestinal parasites: a comparative study of DNA extraction methods
<p>Background</p> <p>Many studies reported high prevalence of <em>H. pylori</em> infection among patients co-infected with intestinal parasites. Molecular approach for the DNA detection of those microbes in stool have been proposed. However there are a few reports that evaluated the effect of bead-beating in relation to the <em>H. pylori</em> outcome. Therefore, we developed and evaluated two TaqMan-based real-time PCR (rt-PCR) qualitative assays for the detection of <em>ureC</em> (<em>glmM</em>) and <em>cagA</em> of <em>Helicobacter pylori</em> on DNA extracted by three procedures.</p> <p>Results</p> <p>The two PCRs were analysed on 100 stool samples from patients who were screened for intestinal parasites. Three DNA extraction procedures were used: 1) automation with bead beating, 2) automation without bead beating and 3) hand column. The specificity of the new assays was confirmed by sequencing the PCR products and by the lack of cross-reactivity with other bacteria or pathogens DNA. Rt-PCR assays showed a detection limit of 10^4 bacteria/200 mg stool. The <em>ureC</em>_PCR with bead beating process was compared to conventional stool antigen test (SAT), with 94.12 and 93.75% of respectively sensitivity and specificity. However, the discordant samples were confirmed by DNA sequencing suggesting a potential higher sensitivity and specificity of PCR.</p> <p>Conclusions</p> <p>Our findings showed that the automation with bead-beating –suggested procedure for intestinal parasitic infections- can reach highly sensitive results in <em>H. pylori</em> detection on stool compared also with SAT. Thus, this work can provide new insights into the practice of a clinical microbiology laboratory in order to optimize detection of gastro-intestinal infections. Further studies are needed to better define the clinical value of this technique.</p>
Data from: Distribution and clinical associations of integrating conjugative elements and cag pathogenicity islands of Helicobacter pylori in Indonesia
The clinical associations and correlations with other virulence factors such as cag pathogenicity island (PAI) of the Integrating Conjugative Elements Helicobacter pylori TFSS (ICEHptfs), a new type IV secretion system (TFSS) in H. pylori has not been described. Among 103 studied strains from Indonesia, almost all strains (99.0%) contained cag PAI with more than half (55.8%) were intact cag PAI. Patients infected with intact cag PAI strains showed significantly higher antral activity, inflammation and atrophy as well as corporal inflammation than those with non-intact cag PAI strains, confirming the virulence of cag PAI. Over half of strains (53.8%) contained ICEHptfs, predominantly consisted of ICEHptfs3-tfs4a (42.8%) and ICEHptfs3 (16.3%). Although patients infected with ICEHptfs-positive strains had lower H. pylori density, those with the complete ICEHptfs4b strains tended to have higher antral activity than the negative one. In combination, patients infected with combination of intact cag PAI-ICEHptfs-positive strains had more severe inflammation than those with non-intact cag PAI-ICEHptfs-negative, suggesting a possibility of a mutual correlation between these TFSS(s).
Endoscopic and histopathological findings in dyspeptic patients with Helicobacter pylori infection
<p><strong>Background: </strong>Despite advancements in medicine, gastrointestinal diseases caused by <em>Helicobacter pylori</em> continue to be common in developing countries. This study analyzed gastric mucosal biopsies from the Manipal College of Medical Sciences in Pokhara, Nepal, between January 2017 and June 2018 to determine the prevalence of <em>H. pylori</em>, its association with histopathological changes, and evaluate it using OLGA and OLGIM systems.</p> <p><strong>Methods: </strong>In this analytical cross-sectional study, 80 patients with dyspepsia were included. Biopsies were collected, stored, and labeled. The biopsies were fixed, cut into sections, and stained with routine H&E and Giemsa stains. Evaluations were made using OLGA and OLGIM staging. Statistical analyses were performed using SPSS version 17.0, with significance determined at p<0.05.</p> <p><strong>Results: </strong>Hospital-visiting patients had an 8.41% (38/452) [10.97–5.85%, 95% Confidence Interval (CI)] rate of <em>H. pylori</em> infection, while dyspeptic patients had 47.50% (38/80) (58.44–36.56, 95% CI). Females (48%, 12/25) and patients aged 31–40 (62.50%, 5/8) were mostly affected. The most common clinical presentation and endoscopic findings relating to infection included weight loss (15.79%) and erythema (44.74%), respectively. Provisional and histopathological diagnoses of <em>infected </em>patients mostly included gastritis (50%) and chronic gastritis (63.16%), respectively. Hundred percent of moderate <em>H. pylori</em> infections were associated with normal atrophy and intestinal metaplasia, while 89.66% of mild infections were associated with mild active and chronic inflammation. OLGIM downgraded one OLGA stage 2 and 4 and two OLGA stage 3 cases.</p> <p><strong>Conclusion: </strong><em>H. pylori</em> infections were most common in adults and females with chronic gastritis. OLGIM was less accurate than OLGA in evaluating high-risk cases, such as adenocarcinomas.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.