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282
datasets available to search
ShareScore release 0.9.0
Dataset results
282 results for “Tumor infiltrating cells”
The roles of Ptpn22 Ser452 phosphorylation in tumor-infiltrating CD8+ T cells from mouse
GEO Series GSE263092. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Expansion of Tumor-Infiltrating CD8+ T Cell Clonotypes Occurs in the Spleen in Response to Immune Checkpoint Blockade
GEO Series GSE270050. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing; Other.
Prostaglandin E2-EP4 signaling shapes immunosuppressive tumor microenvironment in human tumors by suppressing bioenergetics and ribosome biogenesis in infiltrating immune cells [scRNA-seq]
GEO Series GSE242271. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic differences between mouse tumor-infiltrating and splenic regulatory T cells with or without Treg-specific loss of CD177
GEO Series GSE150420. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation [TCR-seq]
GEO Series GSE154604. Mus musculus. 12 samples. Type: Other.
Transcriptomic profiling of tumor-infiltrating Treg cells in Foxp3-Cre-YFP melanoma-bearing mice
GEO Series GSE298145. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
CDK4/6-MEK inhibition in MPNSTs causes plasma cell infiltration, sensitization to PD-L1 blockade, and tumor regression
GEO Series GSE224656. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients
GEO Series GSE192935. Homo sapiens; Mus musculus. 58 samples. Type: Expression profiling by high throughput sequencing.
Single cell gene expression analysis of mouse melanoma tumor infiltrating leukocytes
GEO Series GSE149615. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Combinational targeting CCL7 and Flt3L to promote the expansion and infiltration of cDC1 in tumors enhances T cell activation and anti-PD-1 therapy
GEO Series GSE225164. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and cell-extrinsic fashion [scRNA-seq]
GEO Series GSE290839. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome analysis reveals functional changes in tumor-infiltrating B lymphocytes after chemotherapy in esophageal squamous cell carcinoma
GEO Series GSE199619. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing; Third-party reanalysis.
Transcriptome profile of Responders and Nonresponders T cells infiltrated lymphocytes (TILs) co-cultured with autologous tumor cells from patients with melanoma.
GEO Series GSE215037. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ACSL4-programmed sphingomyelin metabolism rejuvenates tumor-infiltrating T-cells to enhance the efficacy of anti-PD-1 immunotherapy
GEO Series GSE233204. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptome analysis of tumor infiltrating NK and T cells in CT26-bearing BALB/C mice
GEO Series GSE145837. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Combinational targeting CCL7 and Flt3L to promote the expansion and infiltration of cDC1 in tumors enhances T cell activation and anti-PD-1 therapy [Dendritic Cell]
GEO Series GSE225126. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Combinational targeting CCL7 and Flt3L to promote the expansion and infiltration of cDC1 in tumors enhances T cell activation and anti-PD-1 therapy [CD8 T]
GEO Series GSE225163. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas"
<p>This record contains raw data related to article "Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas"</p><p>Introduction: Adult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.</p><p>Methods: In this study, we characterized tumor-infiltrating DCs (TIDCs) in adult patients with newly diagnosed diffuse gliomas by using multi-parametric flow cytometry and single-cell RNA sequencing.</p><p>Results: We demonstrated that different subsets of DCs are present in the glioma microenvironment, whereas they are absent in cancer-free brain parenchyma. The largest cluster of TIDCs was characterized by a transcriptomic profile suggestive of severe functional impairment. Patients undergoing perioperative corticosteroid treatment showed a significant reduction of conventional DC1s, the DC subset with key functions in antitumor immunity. They also showed phenotypic and transcriptional evidence of a more severe functional impairment of TIDCs.</p><p>Discussion: Overall, the results of this study indicate that functionally impaired DCs are recruited in the glioma microenvironment. They are severely affected by dexamethasone administration, suggesting that the detrimental effects of corticosteroids on DCs may represent one of the mechanisms contributing to the already reported negative prognostic impact of steroids on glioma patient survival</p>
Dataset related to article "High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors"
<p>This record contains raw data related to article "High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors"</p> <p>CD8<sup>+</sup> T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8<sup>+</sup> T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors compared with cancer-free tissues and blood. Besides exhausted and activated cells, we identified CXCR5<sup>+</sup> TIM-3<sup>-</sup> CD8<sup>+</sup> T cells with a partial exhausted phenotype, while retaining gene networks responsible for stem-like plasticity and cytotoxicity, as revealed by single cell sequencing of the whole transcriptome. Ex vivo, CXCR5<sup>+</sup> TIM-3<sup>-</sup> CD8<sup>+</sup> T cells displayed enhanced self-renewal and multipotency compared with more differentiated subsets and were largely polyfunctional. Analysis of inhibitory and costimulatory receptors revealed PD-1, TIGIT, and CD27 as possible targets of immunotherapy. We thus demonstrate a hierarchy of differentiation in the context of T cell exhaustion in human cancer similar to that of chronically infected mice, which is further shown to disappear with disease progression.</p>
Gene expression patterns of tumor-infiltrating CD8 T cells according to the CD137 expression in human metastatic ovarian cancer
GEO Series GSE150301. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.