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277
datasets available to search
ShareScore release 0.9.0
Dataset results
277 results for “novel proteins”
Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins [RNA-seq]
GEO Series GSE173183. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
A novel role of stem cell factor SALL4 as an oncofetal protein in hepatocellular carcinoma
GEO Series GSE35965. Homo sapiens. 6 samples. Type: Expression profiling by array.
Proteogenomic integration of single-cell RNA and protein analysis identifies novel tumour-infiltrating lymphocyte phenotypes in breast cancer
GEO Series GSE199219. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins (RNA-seq)
GEO Series GSE225342. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
An investigation into transcriptional changes in developing Arabidopsis leaf caused by novel signalling protein, SPH1.
GEO Series GSE6179. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
TDP-43, a novel rhythmic protein, regulates the ubiquitination degradation of BMAL1, cellular glucose utilization and energy synthesis
GEO Series GSE260737. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A novel approach to identify genes that determine grain protein deviation in cereals
GEO Series GSE59056. Triticum aestivum. 161 samples. Type: Expression profiling by array.
First-in-human study of the novel fibroblast activation protein-targeted 4-1BB agonist RO7122290 in patients with advanced solid tumors
GEO Series GSE212521. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
A novel nuclear protein complex controlling the expression of developmentally regulated genes in Toxoplasma gondii [CUT&TAG]
GEO Series GSE277553. Toxoplasma gondii. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A Novel Cereblon Modulator Targets eRF3 Family Proteins For Cereblon-dependent Destruction
GEO Series GSE76195. Homo sapiens. 16 samples. Type: Expression profiling by array.
A novel role of the RNA binding protein CPEB3 in colorectal cancer progression
GEO Series GSE137306. Homo sapiens. 6 samples. Type: Expression profiling by array.
Identification of the PRC1-interacting protein, L3mbtl3 as a novel gatekeeper of neocortical neurogenesis and proneural gene function [ATAC-seq]
GEO Series GSE179470. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterization of novel zinc finger protein ZNF414 DNA binding and gene regulatory activity by integrative analysis of ChIP-exo, ATAC-seq and RNA-seq data
GEO Series GSE153779. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Alkaline Phosphatase ALPPL2 is a novel pancreatic carcinoma-associated protein
GEO Series GSE42429. Homo sapiens. 9 samples. Type: Expression profiling by array.
Proteomic profiling during human cellular reprogramming identifies distinct protein clusters and novel markers of induced pluripotent stem cells
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Iso-CUT&MAP (Isolated cell-based Cut Under Target and Mapping Apoptotic Protein-binding sequences): a novel strategy for high-resolution mapping of DNA binding sites
GEO Series GSE237814. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"
<p>This record contains raw data related to article "IReduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"</p><p>WHIM syndrome is an inherited immune disorder caused by an autosomal dominant heterozygous mutation in CXCR4.<i> </i>The disease is characterized by neutropenia/leukopenia (secondary to retention of mature neutrophils in bone marrow), recurrent bacterial infections, treatment-refractory warts, and hypogammaglobulinemia. All mutations reported in WHIM patients lead to the truncations in the C-terminal domain of CXCR4, R334X being the most frequent. This defect prevents receptor internalization, and enhances both calcium mobilization and ERK phosphorylation, resulting in increased chemotaxis in response to the unique ligand CXCL12. Here, we describe three patients presenting neutropenia and myelokathexis, but normal lymphocyte count and immunoglobulin levels, carrying a novel Leu317fsX3 mutation in CXCR4, leading to a complete truncation of its intracellular tail. The analysis of the L317fsX3 mutation in cells derived from patients and <i>in vitro</i> cellular models reveals unique signaling features when compared to R334X mutation. L317fsX3 mutation impairs CXCR4 downregulation and β-arrestin recruitment in response to CXCL12 and reduces other signaling events including ERK1/2 phosphorylation, calcium mobilization and chemotaxis, all processes, which are typically enhanced in cells carrying the R334X mutation. Our findings suggest that overall, the L317fsX3 mutation may be causative of a form of WHIM syndrome not associated with an augmented CXCR4 response to CXCL12.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.