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638 results for “thinning”
Input files for targeted MD and umbrella sampling of cardiac thin filament
<p>The cardiac thin filament is comprised of F-actin, tropomyosin, and troponin (cTn). cTn is composed of three subunits: troponin C (cTnC), troponin I (cTnI), and troponin T (cTnT). To computationally study the effect of the thin filament on cTn activation events, we employed targeted molecular dynamics followed by umbrella sampling using a model of the thin filament to measure the thermodynamics of cTn transition events. Our simulations revealed that the thin filament causes an increase in the free energy required to open the cTnC hydrophobic patch and causes a more favorable interaction between this region and the cTnI switch peptide. Mutations to the cTn complex can lead to cardiomyopathy, a collection of diseases that present clinically with symptoms of hypertrophy or dilation of the cardiac muscle, leading to impairment of the heart's ability to function normally, and ultimately myocardial infarction or heart failure. Upon introduction of cardiomyopathic mutations to R145 of cTnI, we observed a general decrease in the free energy of opening the cTnC hydrophobic patch, which is on par with previous experimental results. These mutations also exhibited a decrease in electrostatic interactions between cTnI-R145 and actin-E334. After introduction of a small molecule to the wild-type cTnI-actin interface to intentionally disrupt intersubunit contacts, we successfully observed similar thermodynamic consequences and disruptions to the same protein-protein contacts as observed with the cardiomyopathic mutations. Computational studies utilizing the cTn complex in isolation would have been unable to observe these effects, highlighting the importance of using a more physiologically relevant thin filament model to investigate the global consequences of cardiomyopathic mutations to the cTn complex. </p>
Table 1. Thin-layer chromatography (TLC) result of the 10% ethyl acetate subfraction of meniran leaves
<p>Table 1. Thin-layer chromatography (TLC) result of the 10% ethyl acetate subfraction of meniran leaves</p>
Light-induced nanoscale deformation in azobenzene thin film triggers rapid intracellular Ca2+ increase via mechanosensitive cation channels
<p>This dataset contains raw data for a research article: material characterization data of Disperse Red 1 glass, calcium imaging data of Madin Darby Canine Kidney II epithelial cells that express the genetic calcium indicator jRCaMP1b and immunofluorescence stainings of Piezo1-channels and the actin cytoskeleton in the same cell line.</p> <p>Light induced material deformations were conducted with Zeiss LSM 780 confocal microscope with 488 nm wavelength excitation. The generated topographies were analyzed with atomic force microscopy (AFM) and digital holographic microscopy (DHM), and particle image velocimetry (PIV) was used to determine lateral deformations.</p> <p>Calcium imaging was conducted with the same microscope with 561 nm excitation and calcium signals were recorded in response to light induced material deformations (stimulation performed after 10 frames) (Zeiss C Apo 63x/1.20 objective, pixel size 200 nm, frame rate 1.23 sec/fame, channel1: fluorescence emission, channel2: brightfield). Apical stimulations were conducted with Nikon Eclipse FN1 utilizing micromanipulation (pixel size 200 nm, NIR Apo 40x 0.8W DIC N2 objective). Immunofluorescence stainings (in normal conditions (channel1: nuclei, channel2: Piezo1, channel3: jRCaMP1b, channel4: actin) or after cytochalainD treatment showing actin cytoskeleton depolymerization (channel1: nuclei, channel2: ZO1, channel3: jRCaMP1b, channel4: actin)) were imaged with Nikon A1R (SR Apo TIRF 100x/1.49 objective, pixel size 40 nm, Z-step to 99 nm, deconvolution with Huygens Essential)</p>
Raman spectra for 15 thin films of ZnO and ZnO doped with Sn, Al, Co, Cu
<p>Raman spectra for 15 thin film ZnO and ZnO doped with Sn, Al, Co, Cu received from Dr. Iulia ANTOHE.</p>
Hyytiälä SMEAR II forest year 2020 thinning tree and carbon inventory data
<p>This dataset contains description of thinning, and forest and carbon stock inventory results of the forest stand surrounding SMEAR II research station located in Hyytiälä, Finland.</p> <p>The dataset consists of following files:</p> <p>1. Description of thinning and inventory methods (Hyytiala site description.pdf)</p> <p>2. Forest characteristics before and after the thinning, by measurement plot (Forest characteristics.xlsx)</p> <p>3. Carbon stocks before and after the thinning, as well as carbon stocks in commercial removal, by measurement plot (Carbon stocks.xlsx)</p> <p>4. Equations used for procuding estimates presented in products 2&3 (Equations.xlsx)</p> <p>5. Readme-file explaining details regarding variants in products 2&3 (Readme.xlsx)</p> <p>6. Plot map showing the locations of measurement plots (Plot map.xlsx)</p> <p>7. Tree size distribution before and after the thinning (Tree size distribution.xlsx)</p> <p>8. Cleaned tree-wise inventory data (Plot measurement data 2020.xlsx) from</p> <ul> <li> 2019 understorey measurement results</li> <li> 2020 measurement results</li> <li> Plot 1-24 detailed inventory measurement results</li> </ul>
Covalent Organic Framework Thin-Film Photodetectors from Solution-Processable Porous Nanospheres
<p>This repository contains the source data for the manuscript <strong>"Covalent Organic Framework Thin-Film Photodetectors from Solution-Processable Porous Nanospheres" </strong></p> <p>The statistical model of 50 layers, 4-6 layers for TpDPP, TpTta, and TpTab.</p> <p>A code for building the statistical structure for layered materials by stacking layers following the Maxwell-Boltzmann energy distribution of their stacking modes. Full Changelog: <a href="https://github.com/Ying-Ying-Zhang/COFpiler/commits/v1.1">https://github.com/Ying-Ying-Zhang/COFpiler/commits/v1.1</a></p>
Dataset for the manuscript "Helical and nonhelical dynamos in thin accretion discs"
<p>Dataset and post-processing scripts for the manuscript "Helical and nonhelical dynamos in thin accretion discs".</p>
Thin-butted axe
This axe was found in Hallberg parish, Närke. Thin-butted axes are primarily connected to the Funnel Beaker Culture and dates from the early Neolithic to the Middle Neolithic A, c:a 3700-3200BC. The thin-butted axes were working axes used to cut trees or other wooden elements. These axes are commonly found in megalithic tombs or in depositions. This object was polished on all sides leaving only but a few traces of the previous knapping. This axe also show signs of being used. A large flake of flint has chipped off at the edge of the bit, probably during use. Another large flake has broken off from the other side of the bit, but most probably this happened when the axe was still in the ground, through ploughing or similar events. http://historiska.se/upptack-historien/object/1308310 3D scanning Xenter 3D-tekniker Midori Åstrand Source: Objaverse 1.0 / Sketchfab
The Comparison of Thick Split-thickness Skin Graft Versus Thin Split-thickness Skin Graft
ClinicalTrials.gov study NCT05571904. IPD Sharing: YES. Countries: 1. Publications: 1.
Comparative User Experiences With BD Nano™ PRO 4mm x 32G Extra Thin Wall Pen Needle vs Three Commercially Available Pen Needles
ClinicalTrials.gov study NCT03878758. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery
ClinicalTrials.gov study NCT05033730. IPD Sharing: YES. Countries: 1. Publications: 2.
Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent
ClinicalTrials.gov study NCT02870140. IPD Sharing: UNDECIDED. Countries: 7. Publications: 3.
Comparative User Experiences With BD Nano™ PRO 32G Extra Thin Wall Pen Needle vs the Terumo Nanopass® 34G Pen Needle
ClinicalTrials.gov study NCT03878745. IPD Sharing: NO. Countries: 1. Publications: 6.
Orientation data for: Pre-thrusting stratigraphic control on the transition from a thin- to thick-skinned structural style: an example from the double-decker Idaho-Montana fold-thrust belt
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Thin lines between native and invasive aquatic plants are common, posing challenges for response efforts
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Data from: The 15-year post-treatment response of a mixed-conifer understory plant community to thinning and burning treatments
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Knockdown of BmorCPR67 gene disrupts prepupal–pupal transition of silkworm Bombyx mori by thinning the endocuticle
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Restoration thinning permits stems to capitalise on high-rainfall years in a regenerating endangered forest ecosystem
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Two-step spin-coating of vacancy-ordered double perovskites enables growth of thin films for electronic devices
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Input files for targeted MD and umbrella sampling of cardiac thin filament
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.