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6,517 results for “Clinical trials”
Genome-wide expression profiling of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy.
GEO Series GSE84748. Homo sapiens. 24 samples. Type: Expression profiling by array.
BMX-001, a selective radioprotector in phase II clinical trials, can reverse radiation-induced fibrosis when given three weeks after radiation
GEO Series GSE308163. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
BMX-001, a selective radioprotector in phase II clinical trials, can reverse radiation-induced fibrosis when given three weeks after radiation [Bisulfite-seq]
GEO Series GSE309064. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
The Effectiveness of Strengthening primary health care teams with palliative care leaders: a Pragmatic cluster randomized clinical trial
<p>Full dataset of the clinical trial PI14/01336 Effectiveness of Strengthening primary health care teams with palliative care leaders</p>
The effect of piezocision vs no piezocision on maxillary extraction space closure: a split-mouth, randomized controlled clinical trial.
<p>This is a “2-arm-parallel”, split-mouth trial with the aim to investigate the effects of piezocision compared to no piezocision on maxillary canine distalization and to evaluate patients’ perceptions on the surgical procedure.</p>
Data from: Effect of aerobic exercise on cognition in younger adults: a randomized clinical trial
Objective: To determine efficacy of aerobic exercise for cognitive function in younger healthy adults. Methods: In a randomized, parallel-group, observer-masked, community-based clinical trial, 132 cognitively normal individuals aged 20-67 with below median aerobic capacity were randomly assigned to one of two 6-month, four-times-weekly conditions: aerobic exercise and stretching/toning. Efficacy measures included: aerobic capacity; cognitive function in six domains (executive function, episodic memory, processing speed, language, and attention), everyday function, BMI and cortical thickness. Results: Aerobic capacity increased significantly (β=2.718; p=0.003), and BMI decreased significantly (β=-0.596; p=0.013) in the aerobic exercise but not in the stretching/toning condition. Executive function improved significantly in the aerobic exercise condition; this effect was moderated by age (β=0.018 s.d. per year; p=0.028). At age 40 the executive function measure increased by 0.228 s.d. (95% CI: 0.007 - 0.448), and by 0.596 s.d. (95% CI: 0.219 - 0.973) at age 60. Cortical thickness increased significantly in the aerobic exercise group in a left frontal region and did not interact with age. Controlling for age and baseline performance, individuals with at least one APOE ε4 allele showed less improvement in executive function with aerobic exercise (β=0.5129, 95%CI 0.0381 to 0.988; p=0.0346). Conclusions: This randomized clinical trial demonstrates the efficacy of aerobic exercise for cognition in adults age 20 – 67. The effect of aerobic exercise on executive function was more pronounced as age increased, suggesting that it may mitigate age-related declines. Increased cortical thickness suggests that aerobic exercise contributes to brain health in individuals as young as age 20. Clinicaltrials.gov Identifier: NCT01179958 Classification of evidence: This study provides Class II evidence that for adults age 20-67 with below median aerobic capacity, aerobic exercise significantly improves executive function but not other measures of cognitive function.
Data from: Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: a randomized clinical trial
Background: Adherence to treatment remains the cornerstone of long term viral suppression and successful treatment outcomes among patients receiving Antiretroviral Therapy (ART). Objective(s): Evaluate the effectiveness of mobile phone reminders and peer counseling in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. Methods: A single-blind, parallel group RCT conducted in Hospital Sungai Buloh, Malaysia in which 242 adult Malaysian patients were randomized to intervention or control groups. Intervention consisted of a reminder module delivered through SMS and telephone call reminders by trained research assistants for 24 consecutive weeks (starting from date of ART initiation), in addition to adherence counseling at every clinic visit. The length of intended follow up for each patient was 6 months. Data on adherence behavior of patients was collected using specialized, pre-validated Adult AIDS Clinical Trial Group (AACTG) adherence questionnaires. Data on weight, clinical symptoms, CD4 count and viral load tests were also collected. Data was analyzed using SPSS version 22 and R software. Repeated measures ANOVA, Friedman's ANOVA and Multivariate regression models were used to evaluate efficacy of the intervention. Results: The response rate after 6 months follow up was 93%. There were no significant differences at baseline in gender, employment status, income distribution and residential location of respondents between the intervention and control group. After 6 months follow up, the mean adherence was significantly higher in the intervention group (95.7; 95% CI: 94.39–96.97) as compared to the control group (87.5; 95% CI: 86.14–88.81). The proportion of respondents who had Good (>95%) adherence was significantly higher in the intervention group (92.2%) compared to the control group (54.6%). A significantly lower frequency in missed appointments (14.0% vs 35.5%) (p = 0.001), lower viral load (p = 0.001), higher rise in CD4 count (p = 0.017), lower incidence of tuberculosis (p = 0.001) and OIs (p = 0.001) at 6 months follow up, was observed among patients in the intervention group. Conclusion: Mobile phone reminders (SMS and telephone call reminders) and peer counseling are effective in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. These findings may be of potential benefit for collaborative adherence planning between patients and health care providers at ART commencement.
Global Registry of Clinical Trials for Cirrhosis: Geographical Distribution, Researchers, and Associated Sponsors
<p>The dataset is formed by a compilation of data extracted directly from the website clinicaltrials.gov, specifically focused on studies about hepatic cirrhosis. This dataset includes detailed information such as the identification number of the clinical trials (NCT), the geographical location of the studies, the contact details of the principal investigators, the gender of the patients included in the studies, the names of the sponsors responsible for the research, and the start and end date of the trial. The data has been collected using web scraping techniques, providing a comprehensive database for analysis and research in the field of cirrhosis, a disease that involves a progressive deterioration of liver tissue that can lead to liver failure.</p>
Clinical usability study of a transcranial direct current stimulation for primary dysmenorrhea: a randomized controlled trial
Open the record for dataset details and reuse information.
Figure 1 from: Ivanova S, Petkova V (2022) Specificity of clinical trials of some osteoporosis medicines. Pharmacia 69(1): 99-106. https://doi.org/10.3897/pharmacia.69.e79258
Figure 1 Chemical structures for Alendronbate, Ibandronate, Risedronate and Zoledronate.
Datasets - "Telerehabilitation for visual field defects with a multisensory training: a randomized clinical trial" by Diana et al.
<p>Datasets of this research (Main experiment and Study 2).</p> <p><span>These data cannot be made publicly available because they include sensitive information, but can be made available to interested researchers upon reasonable request. Please, forward your request to Prof. Nadia Bolognini (n.bolognini@auxologico.it).</span></p>
Data from: Influence of needle-insertion depth on epidural spread and clinical outcomes in caudal epidural injections: a randomized clinical trial
Background: A caudal epidural steroid injection (CESI) is a commonly used method to improve symptoms of lumbosacral pain. We compared the achievement of successful epidurograms and patient-reported clinical outcomes following different needle-insertion depths during CESI. Methods: For the conventional method group, the needle was advanced into the sacral canal. For the alternative method group, the needle was positioned immediately after penetration of the sacrococcygeal ligament. Epidural filling patterns and vascular uptake during fluoroscopy were determined to verify successful epidural injection. Procedural pain scores were investigated immediately after the procedure. Pain scores and patient global impression of symptom change were evaluated at 1-month follow-up. Results: Assessments were completed by 127 patients (conventional method, n=64; alternative method, n=63). The incidence of intravascular injection was significantly lower in the alternative method group than in the conventional method group (3.2% vs 20.3%, P=0.005). Procedural pain during needle insertion was significantly lower in the alternative method group (3.7±1.3 vs 5.3±1.2, P<0.001). Epidural contrast filling patterns were similar in both groups. One-month follow-up pain scores and patient global impression of symptom change were comparable in both groups. Conclusion: Compared with the conventional method, the alternative method for CESI could achieve similar epidural spread and symptom improvement. The alternative technique exhibited clinical benefits of a lower rate of intravascular injection and less procedural pain.
EFFECT OF FRENCH MARITIME PINE BARK EXTRACT ON ATTENTION-DEFICIT HYPERACTIVITY DISORDER: A RANDOMIZED CLINICAL TRIAL.
<p>This is a dataset from a phase III, randomised, double-blind, placebo and active product controlled, multicentre clinical trial with three parallel treatment arms to compare effects on ADHD and ADD behaviour between Pycnogenol®, MPH (Medikinet® Retard) and placebo, using the ADHDRating Scale (ADHD-RS/ARS) as a primary outcome measure.</p> <p>Evaluations were performed in weeks 5 and 10, as compared to baseline. Two visits with similar evaluations were conducted: at baseline and after 10 weeks. Next to baseline and final evaluations, an extra evaluation of behaviour and physical symptoms was conducted in week 5 by means of questionnaires. The trial population will consists of ADHD and ADD patients recruited at the University Hospitals of Antwerp (UZA) and Ghent (UZ Ghent) and the Hospital Network Antwerp (ZNA), Belgium. Participants were randomised, stratified by trial centre, to one of the three treatment arms (placebo, Pycnogenol®, or Medikinet® Retard) by randomization.com randomisation software. Published protocol: Verlaet AAJ, Ceulemans B, Verhelst H, Van West D, De Bruyne T, Pieters L, Savelkoul HFJ, Hermans N. Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD): study protocol for a randomised controlled trial. Trials (2017), 18(1).</p> <p>As the primary objective is to assess the efficacy of Pycnogenol® for improving ADHD and ADD behaviour as rated by teachers compared to placebo and Medikinet® Retard, the primary outcome is the summed ADHD score of the ADHD-RS as rated by teachers. Teachers filled out this questionnaire before the start of the intervention and after 5 and 10 weeks. Secondary outcomes ADHD/ADD behaviour Secondary outcomes related to ADHD/ADD behaviour are:</p> <p>Summed ADHD score of the ADHD-RS, rated by parents</p> <p>Summed ADHD score of the Social-emotional Questionnaire (SEQ), rated by parents and teachers</p> <p>Scores on ADHD subscales of the ADHD-RS and SEQ, rated by parents and teachers (hyperactivity, impulsivity and inattention)</p> <p>Percentage of responders rated by parents and teachers, defined as participants with a reduction of at least 20% of their baseline summed ADHD-RS s</p> <p>Social behaviour problems subscale of the SEQ, rated by parents and teachers, to evaluate to what extent symptoms of ODD and CD are displayed</p> <p>Anxiety subscale of the SEQ, rated by parents and teachers, to evaluate symptoms of general anxiety, social anxiety and anxiety-depression</p> <p>Physical and sleep complaints, including various potential side effects, measured by the Physical Complaints Questionnaire (PCQ)</p> <p>Dietary habits of participants were assessed by a Food Frequency Questionnaire (FFQ).</p> <p>The ADHD-RS (ARS) is a validated, internationally accepted questionnaire. Its 9 inattention (IA) and 9 hyperactivity and impulsivity (HI) items, rated on a four-point rating scale (never/seldom 0, sometimes 1, often 2, or very often 3), are based on the DSM. The ADHD-RS was used in previous trials as well. </p> <p>Besides ADHD, the Social-Emotional Questionnaire (SEQ) assesses core symptoms of other social-emotional problems (social behaviour problems, anxiety and autism). Its 72 questions are based on the DSM and rated on a five-point scale (never 0, less than once a month 1, every month 2, every week 3, or (almost) every day 4). The ADHD score can be subdivided into an hyperactivity (H) score, impulsivity (I) score and inattention (IA) score, each based on 6 questions.</p> <p>The PCQ enquires physical and sleep complaints, for instance related to pain, unusual thirst/perspiration, asthma or rhinitis, skin problems, tiredness, gastrointestinal problems and sleep problems. Questions include potential adverse effects and are rated on a five-point scale. In addition to several stand-alone questions, various questions can be combined (e.g. total pain: headache, stomach ache and growing pains). Each item is rated on a five-point scale (never 0, less than once a month 1, every month 2, every week 3, or (almost) every day 4). </p> <p>The FFQ consisted of 50 questions on different food groups to be rated on a nine-point scale (never 0, less than once a month 1, 1-3 times a month 2, once a week 3, 2-4 times a week 4, 5-6 times a week 5, once a day 6, 2-3 times a day 7, more than 3 times a day 8) to assess global dietary habits (e.g. how often a participant consumes fresh fruits or vegetables).</p> <p>Researchers involved in digitalizing questionnaire answers and statistics were blind for the participant groups. In case of >2 missing answers regarding a (sub)score within a patient, this (sub)score was set to missing. Participants were excluded from analyses only for those outcomes without any data available. Several teacher questionnaires were missing due to teachers never responding/not responding anymore, starting/ending the study during the summer holiday, covid-19 (homeschooling), or a combination of these.</p> <p>Data in SPSS were directly used for statistics. Data in excel are raw data.</p>
A Clinical Trial of SIBP-A18 Injection in the Treatment of Advanced Malignant Solid Tumor Patients
ClinicalTrials.gov study NCT06985368. IPD Sharing: NO. Countries: 1. Publications: 0.
Doppler Ultrasound-Guided Angiopuncture for Dysmenorrhea Pain: A Clinical Trial
ClinicalTrials.gov study NCT07176910. IPD Sharing: NO. Countries: 1. Publications: 0.
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers
ClinicalTrials.gov study NCT02312596. IPD Sharing: NO. Countries: 1. Publications: 0.
Continuation Treatment Protocol for Patients Who Participated in the Adagio TVP 1012/501 Clinical Trial
ClinicalTrials.gov study NCT01709461. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase I Clinical Trial of BAT1306 and BAT8001 Injection in Patients With Solid Tumor
ClinicalTrials.gov study NCT04151329. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Randomized, Double-blind, Multi-center, Active-controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of THP-00101, THP-00102, and THP-00103 in Subjects With T
ClinicalTrials.gov study NCT06647745. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)
ClinicalTrials.gov study NCT06908057. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.