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836 results for “Acute Kidney Injury”
Data from: Multi-perspective predictive modeling for acute kidney injury in general hospital populations using electronic medical records
Objective: Acute kidney injury (AKI) in hospitalized patients puts them at much higher risk for developing future health problems such as chronic kidney disease, stroke, and heart disease. Accurate AKI prediction would allow timely prevention and intervention. However, current AKI prediction researches pay less attention to model building strategies that meet complex clinical application scenario. This study aims to build and evaluate AKI prediction models from multiple perspectives that reflect different clinical applications. Material and Methods: A retrospective cohort of 76,957 encounters and relevant clinical variables were extracted from a tertiary care, academic hospital electronic medical record (EMR) system between November 2007 and December 2016. Five machine learning methods were used to build prediction models. Prediction tasks from four clinical perspectives with different modeling and evaluation strategies were designed to build and evaluate the models. Results: Experimental analysis of the AKI prediction models built from four different clinical perspectives suggest a realistic prediction performance in cross-validated AUC ranging from 0.720 to 0.764. Discussion: Results show that models built at admission is effective for predicting AKI events in the next day; models built using data with a fixed lead time to AKI onset is still effective in the dynamic clinical application scenario in which each patient's lead time to AKI onset is different. Conclusion: To our best knowledge, this is the first systematic study to explore multiple clinical perspectives in building predictive models for AKI in the general inpatient population to reflect real performance in clinical application.
Data from: Optimizing mouse surgery with online rectal temperature monitoring and preoperative heat supply. Effects on post-ischemic acute kidney injury.
Body temperature affects outcomes of tissue injury. We hypothesized that online body core temperature recording and selective interventions help to standardize peri-interventional temperature control and the reliability of outcomes in experimental renal ischemia reperfusion injury (IRI). We recorded core temperature in up to seven mice in parallel using a Thermes USB recorder and ret-3-iso rectal probes with three different protocols. Setup A: Heating pad during ischemia time; Setup B: Heating pad from incision to wound closure; Setup C: A ventilated heating chamber before surgery and during ischemia time with surgeries performed on a heating pad. Temperature profile recording displayed significant declines upon installing anesthesia. The profile of the baseline experimental setup A revealed that <1 % of the temperature readings were within the target range of 36.5 to 38.5 °C. Setup B and C increased the target range readings to 34.6 ± 28.0 % and 99.3 ± 1.5 %, respectively. Setup C significantly increased S3 tubular necrosis, neutrophil influx, and mRNA expression of kidney injury markers. In addition, using setup C different ischemia times generated a linear correlation with acute tubular necrosis parameters at a low variability, which further correlated with the degree of kidney atrophy 5 weeks after surgery. Changing temperature control setup A to C was equivalent to 10 minutes more ischemia time. We conclude that body temperature drops quickly in mice upon initiating anesthesia. Immediate heat supply, e.g. in a ventilated heating chamber, and online core temperature monitoring can help to standardize and optimize experimental outcomes.
Raw data - Digital scans - Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses
<p>Raw data of the manuscript "<em>Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses" </em>as published in Scientific Reports (https://doi.org/10.1038/s41598-025-17319-0) are included. Types of included data are:</p> <p> </p> <p>- NDPI files of digital scans showing miRNA in situ hybridization in mouse kidney</p>
Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury
ClinicalTrials.gov study NCT05429515. IPD Sharing: NO. Countries: 0. Publications: 11.
Acute Kidney Injury in Pediatric Polytrauma Patients at Assiut University Trauma Unit: A Cross-Sectional Study on Incidence and Predictive Risk Factors
ClinicalTrials.gov study NCT06177886. IPD Sharing: Not stated. Countries: 0. Publications: 18.
Epidemiology of Acute Kidney Injury in England - 1998 to 2013
ClinicalTrials.gov study NCT02216695. IPD Sharing: NO. Countries: 1. Publications: 0.
Acute Kidney Injury in Poly Trauma Patients
ClinicalTrials.gov study NCT06108765. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors
ClinicalTrials.gov study NCT06697743. IPD Sharing: Not stated. Countries: 0. Publications: 7.
Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
ClinicalTrials.gov study NCT03070353. IPD Sharing: NO. Countries: 0. Publications: 1.
New Methods for Early Detection of Acute Kidney Injury After Heart Surgery
ClinicalTrials.gov study NCT03974347. IPD Sharing: UNDECIDED. Countries: 0. Publications: 5.
Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients
ClinicalTrials.gov study NCT02414906. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Fluid Mobilization in Hospitalized Patients With Acute Kidney Injury
ClinicalTrials.gov study NCT04522635. IPD Sharing: NO. Countries: 0. Publications: 1.
Long-term Survival and Renal Outcomes in Critically Ill Patients After Acute Kidney Injury: Swedish Multi-centre Cohort Study
ClinicalTrials.gov study NCT02424747. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Incidince of Acute Kidney Injury in Children With Community Acquired Pneumonia at Assiut University Children Hospital
ClinicalTrials.gov study NCT06117826. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery
ClinicalTrials.gov study NCT02046135. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Urine and Serum Biomarkers for Early Detection of Acute Kidney Injury
ClinicalTrials.gov study NCT01531985. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery
ClinicalTrials.gov study NCT01245595. IPD Sharing: Not stated. Countries: 1. Publications: 0.
DUR-928 in Subjects With SARS-CoV-2 With Acute Lung, Liver or Kidney Injury
ClinicalTrials.gov study NCT04447404. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Spironolactone on Acute Kidney Injury in Critically Ill Patients
ClinicalTrials.gov study NCT03206658. IPD Sharing: NO. Countries: 0. Publications: 16.
Relation Between Acute Kidney Injury and Mineral Bone Disease
ClinicalTrials.gov study NCT05548725. IPD Sharing: Not stated. Countries: 0. Publications: 3.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
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