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1,356 results for “Human Activities”
THE IMPORTANCE OF KNOWING THE HUMAN FACTOR IN MANAGEMENT ACTIVITIES
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Differences in nanoscale organization of regulatory active and inactive human chromatin Part1
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Differences in nanoscale organization of regulatory active and inactive human chromatin Part2
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Supplementary information: Motor point stimulation activates fewer Ia-sensory nerves than peripheral nerve stimulation in human soleus muscle
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Supplementary File 3; Figures S3.1 to S3.3: Additional photographs, complementing those presented in figure 2, to illustrate different ways in which signs of livestock, humans or wild mammal activity, as well as land cover attributes, were observed and classified
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Linked collectors and determiners for: Entomological Specimens of Museum of Nature and Human Activities, Hyogo Pref., Japan.
Natural history specimen data linked to collectors and determiners held within, "Entomological Specimens of Museum of Nature and Human Activities, Hyogo Pref., Japan". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="https://bionomia.net/dataset/68c30283-d2a7-4742-96cb-52e249598ff9">https://bionomia.net/dataset/68c30283-d2a7-4742-96cb-52e249598ff9</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/68c30283-d2a7-4742-96cb-52e249598ff9">https://gbif.org/dataset/68c30283-d2a7-4742-96cb-52e249598ff9</a>. Formatted as a Frictionless Data package.
Table 1 in Phytoconstituents from Vernonia glaberrima Welw. Ex O. Hoffm. leaves and their cytotoxic activities on a panel of human cancer cell lines
<p><b>Table 1</b> The IC 50 values for the cytotoxic activity of <i>Vernonia glaberrima</i> leaves crude methanolic extract on cancer cell lines for 72-h treatment.</p><table><tbody><tr><th>Cancer cell lines</th><th>IC50 (μg/mL)</th></tr></tbody><tbody><tr><th>A375</th><td>26.23 (1.14)</td></tr><tr><th>HT-29</th><td>101.92 (7.86)</td></tr><tr><th>MCF7</th><td>206.60 (12.72)</td></tr></tbody></table><p>The values are means with SD in parenthesis for three replicates.</p>
Table 2 in Phytoconstituents from Vernonia glaberrima Welw. Ex O. Hoffm. leaves and their cytotoxic activities on a panel of human cancer cell lines
<p><b>Table 2</b> IC 50 values for 72-h treatment with <i>V. glaberrima</i> compounds on different cell lines.</p><table><tbody><tr><th>Treatment</th><th>IC50 (μg/mL)</th></tr></tbody><tbody><tr><th></th><td>A375</td><td>HT-29</td><td>MCF7</td></tr><tr><th>Nonacosanoic acid (1)</th><td>ND</td><td>ND</td><td>ND</td></tr><tr><th>Lupeol (2)</th><td>59.18 (2.70)</td><td>15.24 (1.15)</td><td>34.15 (2.32)</td></tr><tr><th>5-Methylcoumarin-4-β- glucoside (3)</th><td>91.84 (6.78)</td><td>20.00 (1.60)</td><td>ND</td></tr><tr><th>4-Hydroxy-5-methylcoumarin (4)</th><td>139.53 (10.79)</td><td>4.22 (0.13)</td><td>ND</td></tr><tr><th>5-Fluorouracil</th><td>3.91 (0.25)</td><td>8.00 (0.78)</td><td>4.33 (0.11)</td></tr></tbody></table><p>The values represent means obtained results of triplicate experiments with SD in parenthesis, ND depicts no detected activity.</p>
Data from: Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models
Animals and humans have a tendency to repeat recent choices, a phenomenon known as choice hysteresis. The mechanism for this choice bias remains unclear. Using an established, biophysically informed model of a competitive attractor network for decision making, we found that decaying tail activity from the previous trial caused choice hysteresis, especially during difficult trials, and accurately predicted human perceptual choices. In the model, choice variability could be directionally altered through amplification or dampening of post-trial activity decay through simulated depolarizing or hyperpolarizing network stimulation. An analogous intervention using transcranial direct current stimulation (tDCS) over left dorsolateral prefrontal cortex (dlPFC) yielded a close match between model predictions and experimental results: net soma depolarizing currents increased choice hysteresis, while hyperpolarizing currents suppressed it. Residual activity in competitive attractor networks within dlPFC may thus give rise to biases in perceptual choices, which can be directionally controlled through non-invasive brain stimulation.
Figure 5 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 5 Compound 5 induces the ER-mediated apoptosis. A) Representative Western blot showing the enhanced release of Smac/DIABLO but not cytochrome c from the mitochondria (MF) into the cytosol (CF) of compound 5-treated A549 lung cancer cells (GI50). Equal protein loading was controlled by staining membranes with Ponceau S (a representative section of the stained membrane is shown). The experiment was repeated three times and the corresponding quantification is shown in (B), B) Quantification of smac/DIABLO and cytochrome C levels in vehicle-treated control A549 cells and cells treated with GI50 amount of compound 5 or 5% DMSO as a negative control. M: mitochondria fraction; C: cytosol fraction. Scale bars: mean ± SEM of three independent experiments. ** p < 0.01 compared to vehicle-treated control cells, C) Representative Western blot showing the induction of phosphorylation of eukaryotic initiation factor-2 (eIF-2) in A549 cells treated with GI50 amounts of compound 5. For comparison purposes, thapsigargin (TG), an ER stress-causing drug was used (3 μM, 2 h) as a positive control. The experiment was repeated three times.
Figure 4 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 4 Compound 5 causes caspase activation. A) qRT-PCR analysis of caspase 3, 4, 8 and 9 mRNA in compound 5-treated cells (GI50) as compared to vehicle-treated control cells [set as 1 arbitrary unit (a.u.)]. Values were normalized to β-actin. Scale bars: mean ± SEM of three independent experiments performed in triplicates. *p < 0.05, **p < 0.01 compared to vehicle-treated control cells, B) Representative Western blots showing cleavage "activation' of procaspase 3 to the active form p17, procaspase 4 to the active form p20, and procaspase 9 to the active forms p35/p37. C: vehicle-treated control cells; 0.5%: 0.5% DMSO-treated cells; 1%: 1% DMSO-treated cells; 5%: 5% DMSO-treated cells; C.5: Compound 5-treated cells. The experiment was repeated three times.
Figure 2 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 2 The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) assay results for compound 5 against MCF10A cells, and white blood cells (WBC) after 24, 48 and 72 h of treatment.
Figure 3 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 3 Compound 5 induces apoptosis in A549 lung cancer cells. A) Fluorescence images of A549 lung cancer cells showing fragmented nuclei after DAPI staining. Scale bar: 10 µm, B) Detection of DNA fragmentation by agarose gel electrophoresis. Cells were treated and genomic DNA was extracted and electrophoresed on 1.5% agarose gels. M: DNA molecular weight marker; C: vehicle-treated control cells; 1%: 1% DMSO-treated cells; 5%: 5% DMSO-treated cells; C.5: Compound 5-treated cells. Arrows indicate DNA fragments. Three experiments were performed with similar results.
Figure 6 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 6 3D View of the target compounds (5, 7A, 6B and 6C) docked against ATP binding site of EGFR kinase.
Fig. 4 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 4. Electronic circular dichroism (ECD) spectra of 1 6, and 9 in EtOH.
Fig. 3 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 3. The key NOESY correlations of cyclohexenyl unit of 5 9.
Fig. 1 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 1. Structures of isolated compounds from B. rotunda.
Treatment of Anal Fissure by Activated Human Macrophages
ClinicalTrials.gov study NCT00507364. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Complement-activating Anti-human Leucocyte Antigen Donor Specific Antibodies in Solid Organ Transplantation
ClinicalTrials.gov study NCT03438058. IPD Sharing: NO. Countries: 0. Publications: 1.
Effects of rTMS on Human Brain Activity Measured With fMRI
ClinicalTrials.gov study NCT03259568. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.