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1,049 results for “Pseudomonas”
Quorum sensing inhibitor against Pseudomonas aeruginosa biofilm
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Pseudomonas aeruginosa - hashed WhatsGNU basic database
<p>WhatsGNU hashed basic database for <em>Pseudomonoas aeruginosa. </em></p>
Data from: Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa
Antibiotic resistance is a growing concern to public health. New treatment strategies may alleviate the situation by slowing down the evolution of resistance. Here, we evaluated sequential treatment protocols using two fully independent laboratory-controlled evolution experiments with the human pathogen Pseudomonas aeruginosa PA14 and two pairs of clinically relevant antibiotics (doripenem/ciprofloxacin and cefsulodin/gentamicin). Our results consistently show that the sequential application of two antibiotics decelerates resistance evolution relative to monotherapy. Sequential treatment enhanced population extinction although we applied antibiotics at sub-lethal dosage. In both experiments, we identified an order-effect of the antibiotics used in the sequential protocol, leading to significant variation in the long-term efficacy of the tested protocols. These variations appear to be caused by asymmetric evolutionary constraints, whereby adaptation to one drug slowed down adaptation to the other drug, but not vice versa. An understanding of such asymmetric constraints may help future development of evolutionary robust treatments against infectious disease.
Fig. 2 in Isobenzofuranones and isocoumarins from kiwi endophytic fungus Paraphaeosphaeria sporulosa and their antibacterial activity against Pseudomonas syringae pv. actinidiae
Fig. 2. Key HMBC and ROESY correlations of compounds 1, 4, and 5.
Fig. 1 in Isobenzofuranones and isocoumarins from kiwi endophytic fungus Paraphaeosphaeria sporulosa and their antibacterial activity against Pseudomonas syringae pv. actinidiae
Fig. 1. Chemical structures of compounds 1–14.
Fig. 4. ECD calculations for 2 in Isobenzofuranones and isocoumarins from kiwi endophytic fungus Paraphaeosphaeria sporulosa and their antibacterial activity against Pseudomonas syringae pv. actinidiae
Fig. 4. ECD calculations for 2.
Fig. 3 in Isobenzofuranones and isocoumarins from kiwi endophytic fungus Paraphaeosphaeria sporulosa and their antibacterial activity against Pseudomonas syringae pv. actinidiae
Fig. 3. ORTEP drawings of 1 and 4.
Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 in Subjects With Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection
ClinicalTrials.gov study NCT05616221. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients With Pseudomonas Aeruginosa (PA)
ClinicalTrials.gov study NCT00128492. IPD Sharing: Not stated. Countries: 4. Publications: 0.
The Use of Inhaled Aztreonam in Children With a Tracheostomy Tube and Pseudomonas
ClinicalTrials.gov study NCT03158116. IPD Sharing: NO. Countries: 1. Publications: 0.
Detection of Pseudomonas Aeruginosa in the Airways of Patients With CF
ClinicalTrials.gov study NCT01303068. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ph 1/2 Study Evaluating Safety and Tolerability of Inhaled AP-PA02 in Subjects With Chronic Pseudomonas Aeruginosa Lung Infections and Cystic Fibrosis
ClinicalTrials.gov study NCT04596319. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety of AZLI in Children With Cystic Fibrosis (CF) and Chronic Pseudomonas Aeruginosa in the Lower Airways
ClinicalTrials.gov study NCT01404234. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Safety and Tolerability Study of 2 Dose Level of Arikayce™ in Patients With Bronchiectasis and Chronic Infection Due to Pseudomonas Aeruginosa.
ClinicalTrials.gov study NCT00775138. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Bacteriophage Clinical Trial for Periprosthetic Joint Infection of Multidrug Resistant Pseudomonas Aeruginosa
ClinicalTrials.gov study NCT06798168. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Data from: Selection experiments reveal trade-offs between swimming and twitching motilities in Pseudomonas aeruginosa
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Data from: Evolution of fitness trade-offs in locally adapted populations of Pseudomonas fluorescens
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Data from: Cheating and resistance to cheating in natural populations of the bacterium Pseudomonas fluorescens
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Data from: Co-evolutionary dynamics between public good producers and cheats in the bacterium Pseudomonas aeruginosa
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Data from: Evolutionary dynamics of separate and combined exposure of Pseudomonas fluorescens SBW25 to antibiotics and bacteriophage
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.