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299 results for “niche models”
Exploring the Mechanisms of Resistance of Stem Cells Myeloproliferative Opposite of Tyrosine Kinase Inhibitors in 3d Model Niche Endosteal
ClinicalTrials.gov study NCT02766153. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Single cell RNA sequencing of the lung pre-metastatic niche in a syngeneic mouse model of rhabdomyosarcoma
GEO Series GSE168297. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a 3D organoid model
GEO Series GSE257536. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models [DSP]
GEO Series GSE249538. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing; Other.
Clearance of a senescent macrophage-enriched niche ameliorates tumorigenesis in KRAS-driven murine lung cancer models
GEO Series GSE203447. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Can we implement mechanistic niche models without measuring traits?
<p>Despite increasing demand for more mechanistic models of species' distributions, they remain difficult to implement due to their intense data requirements. Here, we suggest that three existing tools might help researchers estimate missing trait data that can fill necessary requirements: phylogenetic imputation (incorporating evolutionary relationships into the imputation process), allometry, and biophysics. These tools can bridge the gap between species for which we have fairly little data and ecological models of their distributions. We focus on ecophysiological traits of salamanders; a simple theoretical model of water loss showed that changing body mass results in a decrease in mass-specific water loss, driven by both increasing total size and increasing the thickness of the epidermis. Yet this has two costs – mass-specific oxygen absorption decreases with the surface area-to-volume ratio, and a thicker epidermis slows the rate of respiration. Using a mechanistic distribution model, we modeled the ranges of six species of lungless, terrestrial salamanders. The model performed well for two species of <i>Plethodon</i> and one species of <i>Desmognathus</i>, but poorly for three other species; this discrepancy likely reflects biases in the data available to build the imputation model and biological assumptions on which the mechanistic distribution model is based. Though overall model performance was mediocre, the parameter estimates used in this study may be useful when fewer total parameters are missing. We provide relevant R functions for the mechanistic niche model in the package 'ManderGander'.</p>
Fig. 6 in Distribution of Tomicus destruens (Coleoptera: Scolytinae) mitochondrial lineages: phylogeographic insights and niche modelling
Fig. 6 Tests for niche similarity applied to level 3 clades about the D metric. The first row shows the background test with 100 km buffer, and the second row illustrates the background test with 20 km buffer. Black dashed lines indicate the observed overlap values
Fig. 4 in Distribution of Tomicus destruens (Coleoptera: Scolytinae) mitochondrial lineages: phylogeographic insights and niche modelling
Fig. 4 Potential distribution of the analysed lineages with a probability ≥0.40. a Clades 3 level. b Clades haplotype level
Fig. 3 a, b in Distribution of Tomicus destruens (Coleoptera: Scolytinae) mitochondrial lineages: phylogeographic insights and niche modelling
Fig. 3 a, b Spatial distribution of haplotypes and level 3 clades used in the maximum entropy methodology (MaxEnt)
Fig. 5 a,b Ecological niche models obtained for S. caeruleus populations. a Chihuahuan Desert, b in Molecular evidence for the origin and evolutionary history of the rare American desert monotypic family Setchellanthaceae
Fig. 5 a,b Ecological niche models obtained for S. caeruleus populations. a Chihuahuan Desert, b Tehuacán-Cuicatlán Valley
FIGURE 6 in Systematics and biogeography of Anoura cultrata (Mammalia, Chiroptera, Phyllostomidae): a morphometric, niche modeling, and genetic perspective, with a taxonomic reappraisal of the genus
FIGURE 6. Maximum likelihood tree of cytochrome c oxidase subunit 1 DNA sequences in species of the nectar-feeding bat Anoura. Bootstrap support percentages from 1,000 replications are at the nodes. The geographic origins of samples included in the tree are indicated.
Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models [RNA-seq]
GEO Series GSE249539. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Can we implement mechanistic niche models without measuring traits?
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An organoid-based transplantation model reveals genetic interactions potentiating niche-independent gastric carcinogenesis
GEO Series GSE192604. Mus musculus. 8 samples. Type: Expression profiling by array.
Single Cell Transcriptomics Reveals a Tumor Promoting Mammary Cell Niche in Brca1 Heterozygous Breast Cancer Mouse Model
GEO Series GSE255547. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Ecological niche models for British Columbia's rare species (Red-, Blue-, and SARA-listed) -- Climate normal and future (2050s & 2080s) distributions
<p>Maps of Maxent ecological niche models for Red-listed, Blue-listed and SARA Schedule 1 species in British Columbia. Models were calibrated for species' ranges across Turtle Island under climate normal conditions (1961-1990) and projected into future periods (2050s and 2080s) based on an ensemble of GCMs under SSP 2-4.5.</p>
Fig. 1 in Distribution of Tomicus destruens (Coleoptera: Scolytinae) mitochondrial lineages: phylogeographic insights and niche modelling
Fig. 1 Study area and sampling plots showing the presence of Tomicus destruens
Inflammation favors the emergence of ETV6-RUNX1-positive pre-leukemic cells in a model of mesenchymal niche
GEO Series GSE134437. Mus musculus. 8 samples. Type: Expression profiling by array.
Ecological niche models for focal SARA-listed species in British Columbia
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.