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5,946 results for “Type 2 diabetes”
Ten-hour time-restricted eating improves glycaemic control and alters transcriptomic profile in adipose tissue in men at increased risk of type 2 diabetes
GEO Series GSE168705. Homo sapiens. 96 samples. Type: Expression profiling by high throughput sequencing.
Spatial Transcriptomic Profiling of the Type 2 Diabetic Coronary Microcirculation Reveals Heterogeneity Varied by Regions of the Heart [scRNA-seq]
GEO Series GSE290095. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of kidney glomeruli and renal tubules from Type 2 diabetic (db/db) and non-diabetic mice
GEO Series GSE184836. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Using a modular massively parallel reporter assay to discover context-specific regulatory grammars in type 2 diabetes - Kyono library
GEO Series GSE279057. Rattus norvegicus; synthetic construct. 4 samples. Type: Other.
Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes
GEO Series GSE198906. Rattus norvegicus; Homo sapiens; Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes [methylation array]
GEO Series GSE272137. Homo sapiens. 52 samples. Type: Methylation profiling by array.
Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis
GEO Series GSE193436. Homo sapiens. 18 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes
GEO Series GSE38291. Homo sapiens. 32 samples. Type: Methylation profiling by array.
Glycine Receptor Activity in β Cells Is Downregulated in Type 2 Diabetes and After High Glucose Culture
GEO Series GSE280267. Homo sapiens. 199 samples. Type: Expression profiling by high throughput sequencing.
Identification of circulating miRNA molecular signature for erectile dysfunction in type 2 diabetes
GEO Series GSE182053. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Using a modular massively parallel reporter assay to discover context-specific regulatory grammars in type 2 diabetes - Tovar library
GEO Series GSE279071. synthetic construct; Rattus norvegicus. 6 samples. Type: Other.
Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provide Insights into Type 2 Diabetes Genetics [RNA-seq]
GEO Series GSE251911. Homo sapiens. 58 samples. Type: Expression profiling by high throughput sequencing.
Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids
GEO Series GSE302054. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Hepatic T-cell senescence is implicated in the progression of fatty liver disease in patients with type 2 diabetes
GEO Series GSE239612. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Opportunistic screening for type 2 diabetes in community pharmacies.
<p>Minimal anonymized data set necessary to replicate the sstudy : "Opportunistic screening for type 2 diabetes in community pharmacies. Results from a region-wide experience in Italy" to be published in PlosOne.</p>
Data from: Remission of type 2 diabetes following a short-term intervention with insulin Glargine, Metformin and Dapagliflozin.
<p>This dataset contains Supplemental Tables for the manuscript.</p>
Large-scale analyses provide no evidence for gene-gene interactions influencing type 2 diabetes risk
<p>Summary statistics for "Large-scale analyses provide no evidence for gene-gene interactions influencing type 2 diabetes risk"</p> <p> </p>
Data from: Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
Background: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels. Results: We analyzed the evolutionary history of G6Pase genes. Results indicated that the three paralogs originated during early vertebrate evolution and that negative selection was the major force shaping diversity at these genes in mammals. Nonetheless, site-wise estimation of evolutionary rates at corresponding sites revealed weak correlations, suggesting that mammalian G6Pases have evolved different structural features over time. We also detected pervasive positive selection at mammalian G6PC2. Most selected residues localize in the C-terminal protein region, where several human variants associated with FG levels also map. This region was re-sequenced in ~560 subjects from Saudi Arabia, 185 of whom suffering from type 2 diabetes (T2D). The frequency of rare missense and nonsense variants was not significantly different in T2D and controls. Association analysis with two common missense variants (V219L and S342C) revealed a weak but significant association for both SNPs when analyses were conditioned on rs560887, previously identified in a GWAS for FG. Two haplotypes were significantly associated with T2D with an opposite effect direction. Conclusions: We detected pervasive positive selection at mammalian G6PC2 genes and we suggest that distinct haplotypes at the G6PC2 locus modulate susceptibility to T2D.
Data from: Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study
Objectives: Obesity is a risk factor for type 2 diabetes mellitus. Among obesity, visceral fat obesity, and ectopic fat obesity, it has been unclear which has the greatest effect on incident diabetes. Methods: In this historical cohort study of 8430 men and 7034 women, we investigated the effect of obesity phenotypes on incident diabetes. Obesity, visceral fat obesity, and ectopic fat obesity were defined as body mass index ≥25 kg/m2, waist circumference ≥90 cm in men or ≥80 cm in women, and having fatty liver diagnosed by abdominal ultrasonography, respectively. We divided the participants into eight groups according to the presence or absence of the three obesity phenotypes. Results: During the median 5.8 years follow-up for men and 5.1 years follow-up for women, 286 men and 87 women developed diabetes. Compared to the non-obese group, the hazard ratios (HRs) of incident diabetes in the only-obesity, only-visceral fat obesity, only-ectopic fat obesity groups, and with all-three types of obesity group were 1.85 (95%CI 1.06–3.26, p = 0.05) in men and 1.79 (0.24–13.21, p = 0.60) in women, 3.41 (2.51–4.64, p < 0.001) in men and 2.30 (0.87–6.05, p = 0.12) in women, 4.74 (1.91–11.70, p < 0.001) in men and 13.99 (7.23–27.09, p < 0.001) in women and 10.5 (8.02–13.8, p < 0.001) in men and 30.0 (18.0–50.0, p < 0.001) in women. Moreover, the risk of incident diabetes of the groups with ectopic fat obesity were almost higher than that of the four groups without ectopic fat obesity. Conclusion: Ectopic fat obesity presented the greatest risk of incident type 2 diabetes.
fritzvascones: Analysis code | All-cause mortality attributable to type 2 diabetes mellitus in Peru: a comparative risk assessment analysis
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.