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Dataset results
320 results for “CAMP”
Simulations of PKA RIα Homodimer Reveal cAMP-coupled Conformational Dynamics of Each Protomer and the Dimer Interface with Functional Implications
<p>Protein kinase A (PKA) is a ubiquitous cAMP-dependent enzyme in mammalian tissues. The inactive PKA holoenzyme disassociates into a homodimer of regulatory (R) subunits and two active catalytic (C) subunits upon cAMP binding to two tandem domains (termed <span>CBD-A</span> <span>and</span> <span>CBD</span>-<span>B</span>) in R subunits. The release of cAMP facilitates reassociation of R and C subunits<span>,</span> resetting PKA to its basal state. The cAMP-mediated structural changes in the activation-termination cycle <span>remain</span> <span>partially</span> <span>understood</span>. The multimeric states of PKA complicate the issue and are particularly <span>less</span> <span>studied</span>. Therefore, we computationally investigate the conformational dynamics of PKA <span>RI</span>a homodimer in different cAMP-bound states. The absence of cAMP in two CBDs affect differently the <span>conformational</span> <span>dynamics</span> of protomers. Moreover, <span>such</span> disparate <span>responses</span> are extended to the dimer interface <span>constituted</span> <span>by</span> <span>the</span> <span>N</span>-<span>terminal</span> <span>helical</span> <span>sub-domains</span> termed N3A motifs. T<span>he removal of cAMP from CBD-A induces large-scale structure</span> changes <span>of individual </span>R subunits <span>towards the holoenzyme state,</span> consist with previous simulations of a single R subunit. <span>Meanwhile</span> <span>it</span> <span>keeps the structural heterogeneity of the </span>N3A-N3A' <span>dimer interface observed in the fully bound state.</span> By contrast, the removal of cAMP from CBD-B does not affect <span>individual </span>R subunits but alters the conformational space of the N3A-N3A' dimer interface. The cAMP-coupled s<span>tructural</span> <span>changes</span> <span>of</span> <span>each</span> <span>protomer</span> <span>and</span> conserved conformational space of <span>the</span> N3A-N3A' <span>dimer</span> <span>interface</span> are essential for t<span>he</span> <span>transition</span> <span>between</span> the fully cAMP-bound R<sub>2</sub> homodimer and the R<sub>2</sub>C<sub>2</sub> holoenzyme as suggested by their crystal structures. Our work provides structural insights into <span>the</span> regulatory mechanism of cAMP in PKA signaling. </p>
Spatial targeting of the prostaglandin receptor EP2 is essential in driving a sustained PGE2-mediated cAMP signaling in the human endometrium
GEO Series GSE246497. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Genome wide H3K27ac status of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown
GEO Series GSE148620. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Regulation of Gamma globin gene expression by AT2 and its associated proteins through the cAMP response element.
GEO Series GSE50165. Homo sapiens. 4 samples. Type: Expression profiling by array.
Inactivation of Oncogenic cAMP-specific Phosphodiesterase 4D by miR-139-5p in Response to p53 Activation
GEO Series GSE79099. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
cAMP response element-binding protein mediates immune-evasion of KRAS-mutant lung adenocarcinomas
GEO Series GSE156513. Mus musculus. 2 samples. Type: Expression profiling by array.
cAMP-induced nuclear condensation of CRTC2 promotes transcription elongation and cystogenesis in autosomal dominant polycystic kidney disease
GEO Series GSE173695. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly
GEO Series GSE181263. Schizosaccharomyces pombe. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Parathyroid Hormone Receptor-1 Signaling Aggravates Hepatic Fibrosis through Upregulating cAMP Response Element Binding Protein-Like 2 (mouse)
GEO Series GSE227901. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
MiR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.
GEO Series GSE182413. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
MiR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells [miRNA]
GEO Series GSE182498. Homo sapiens; Rattus norvegicus. 2 samples. Type: Non-coding RNA profiling by array.
cAMP Ca2+ NFAT signalling in RPTEC control vs. CAA
GEO Series GSE4956. Homo sapiens. 8 samples. Type: Expression profiling by array.
cAMP-induced nuclear condensation of CRTC2 promotes transcription elongation and cystogenesis in autosomal dominant polycystic kidney disease (ChIP-Seq)
GEO Series GSE173694. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
cAMP-MicroRNA-203-IFNγ Network Regulates Subcutaneous White Fat Browning and Glucose Tolerance
GEO Series GSE133142. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Parathyroid Hormone Receptor-1 Signaling Aggravates Hepatic Fibrosis through Upregulating cAMP Response Element Binding Protein-Like 2
GEO Series GSE227904. Homo sapiens; Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Cholera toxin mediates cAMP-dependent CTLA-2 secretion by dendritic cells to induce regulatory T cells in the EAE model
GEO Series GSE79274. Mus musculus. 6 samples. Type: Expression profiling by array.
Dietary Habits of Saharawi Type II Diabetic Women Living in Algerian Refugee Camps: Relationship with Nutritional Status and Glycemic Profile
<p>Diabetes is one of the main health problems among Saharawi refugees living in Algerian camps, especially for women. As is known, diet plays an important role in the management of diabetes. However, the dietary habits of Saharawi diabetic women are unknown. Therefore, we investigated the dietary habits and established their relationship with the nutritional status and glycemic profile of such women. We recruited 65 Saharawi type II diabetic women taking orally glucose-lowering drugs only. Dietary habits were investigated using qualitative 24 h recall carried out over three non-consecutive days. Anthropometric measurements were taken and blood parameters were measured. About 80% of the women were overweight and about three out of four women had uncompensated diabetes and were insulin resistant. The Saharawi diet was found to mainly include cereals, oils, sugars, vegetables (especially onions, tomatoes, and carrots), tea, and meat. Principal component analysis identified two major dietary patterns, the first one "healthy" and the second one "unhealthy". Women in the higher tertile of adherence to the unhealthy dietary pattern had a higher homeostatic model assessment for insulin resistance (HOMA) index (b = 2.49; 95% CI: 0.41-4.57; <em>p</em> = 0.02) and circulating insulin (b = 4.52; 95% CI: 0.44-8.60; <em>p</em> = 0.03) than the women in the lowest tertile. Food policies should be oriented to improve the quality of diet of Saharawi diabetic women.</p>
Expression data from BeWo cells treated without or with PKA- or EPAC-selected cAMP analogs
GEO Series GSE100095. Homo sapiens. 9 samples. Type: Expression profiling by array.
Genome wide RNA expression profile of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown
GEO Series GSE148621. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Parathyroid Hormone Receptor-1 Signaling Aggravates Hepatic Fibrosis through Upregulating cAMP Response Element Binding Protein-Like 2 (human)
GEO Series GSE227902. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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