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315
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ShareScore release 0.9.0
Dataset results
315 results for “Cortisol”
Gene expression in Atlantic salmon skin in response to infection with the parasitic copepod Lepeophtheirus salmonis, cortisol implant, and their combination
GEO Series GSE36072. Salmo salar. 16 samples. Type: Expression profiling by array.
Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood
GEO Series GSE147058. Homo sapiens. 96 samples. Type: Methylation profiling by array.
Microarray analysis of transcripts in the liver of gilthead sea bream with high plasma cortisol levels induced by slow-release cortisol implants
GEO Series GSE30782. Sparus aurata. 9 samples. Type: Expression profiling by array.
Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumors in dogs and identifies CYP26B1 as a potential new therapeutic target
GEO Series GSE196108. Canis lupus familiaris. 59 samples. Type: Expression profiling by high throughput sequencing.
Longitudinal Study of Cortisol and Pulmonary Function
ClinicalTrials.gov study NCT00005370. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Gene expression profiles in cows subjected to different stress level as assessed by cortisol in milk
GEO Series GSE146971. Bos taurus. 13 samples. Type: Expression profiling by high throughput sequencing.
High expression of adrenal cortisol synthases is acquired after intrauterine inflammation in periviable sheep fetuses
GEO Series GSE230267. Ovis aries. 10 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide DNA methylation in cows subjected to different stress level as assessed by cortisol in milk
GEO Series GSE146877. Bos taurus. 20 samples. Type: Methylation profiling by high throughput sequencing.
Adrenalectomy Improves Blood Pressure and Metabolic Control in Patients With Possible Autonomous Cortisol Secretion: Results of a RCT.
<p><strong>Objective:</strong> The best approach to patients with adrenal incidentaloma (AI) and possible autonomous cortisol secretion (PACS) is debated. The aim of this study was to assess the metabolic effect of adrenalectomy in AI patients with PACS in relation to cortisol secretion parameters, peripheral activation, and glucocorticoid sensitivity. <strong>Design:</strong> This is a multicenter randomized study (NCT number: NCT04860180). <strong>Methods:</strong> Sixty-two AI outpatients (40–75 years) with AI >1 cm and cortisol after overnight dexamethasone suppression test (F-1mgDST) between 50 and 138 nmol/L were randomized to adrenalectomy (Arm A) or a conservative approach (Arm B). Fifty-five patients completed the 6-month follow-up, 25 patients in Arm A (17 female patients, aged 62.5 ± 10.4 years) and 30 patients in Arm B (24 female patients, 66.1 ± 9.1 years). Plasma adrenocorticotroph hormone (ACTH), 24-h urinary free cortisol, 24-h urinary free cortisone, F-1mgDST, glucose, lipids, glycated hemoglobin (HbA1c) levels, blood pressure (BP), body weight, and treatment variations were assessed. The 24-h urinary free cortisol/cortisone ratio (an 11-beta hydroxysteroid dehydrogenase type 2 activity marker), BclI, and the N363S variants of glucocorticoid receptor (GR) polymorphisms were also evaluated. <strong>Results:</strong> BP control improved in 68% and 13% of the subjects in Arm A and Arm B, respectively (<em>p</em> = 0.001), and the glycometabolic control improved in 28% and 3.3% of the subjects in Arm A and Arm B patients, respectively (<em>p</em> = 0.02). Arm A subjects more rarely showed the BP and/or glycometabolic control worsening than Arm B patients (12% and 40%, respectively, <em>p</em> = 0.03). The surgical approach was independently associated with BP amelioration (OR 3.0, 95% CI 3.8–108.3, <em>p</em> < 0.001) but not with age, F-1mgDST levels, BMI, and hypertension and diabetes mellitus presence at baseline. The 24-h urinary free cortisol/cortisone ratio and the presence of sensitizing GR polymorphisms were not associated with the surgical outcome. The receiver operating characteristic (ROC) curve analysis showed that the BP control amelioration was associated with F-1mgDST [area under the curve (AUC), 0.82 ± 0.09 <em>p</em> = 0.012]. The F-1mgDST cutoff with the best compromise in predicting the BP amelioration was set at 75 nmol/L (sensitivity 77%, specificity 75%). <strong>Conclusions:</strong> AI patients with PACS benefit from surgery in terms of BP and glycometabolic control.</p>
Telomere length and salivary cortisol stress reactivity in very preterm infants
<p>Raw data of the study "Telomere length and salivary cortisol stress reactivity in very preterm infants" In this study, we prospectively examined the relationship between NICU pain-related stress and HPA axis reactivity to an age-appropriate socio-emotional condition (i.e., the Still-Face Procedure, SFP) in healthy VPT infants at 3-month corrected age. NICU pain-related stress was computed as the ratio between the number of skin-breaking procedures and length of NICU stay. A differential score (i.e., ∆TL) was obtained subtracting TL at birth from TL at discharge. A normalized (log10) cortisol reactivity index (CRI) was obtained by averaging post-stress (20 min after SFP) salivary cortisol sample on baseline value. A regression model controlling for neonatal and socio-demographic confounders showed that ∆TL was the only significant predictor of CRI. Although preliminary, these findings contribute to our knowledge of the mechanisms linking early exposures to adversity and later in life regulation of the HPA axis in VPT infants.</p>
Mental Health in Patients With Adrenal Incidentalomas: Is There a Relation With Different Degrees of Cortisol Secretion?
<p>Dataset for the paper Mental Health in Patients With Adrenal Incidentalomas: Is There a Relation With Different Degrees of Cortisol Secretion? </p>
The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
<p>This is a database used for a retrospective observational study, about patients with nonfuncioning adrenal tumors. We recorded the available clinical and biochemical data of all patients with adrenal incidentalomas and without mild autonomous cortisol secretion referred to the participating centres from December 2003 to December 2021.</p>
ADHD Hair Cortisol & Cognition
<p>Dataset of 53 adolescents with ADHD that explored cognitive abilities and hair cortisol concentrations.</p>
Increased risk of vertebral fractures in patients with mild autonomous cortisol secretion
<p>This is a database used for a retrospective observational study focused on patients diagnosed with adrenal incidentalomas. </p> <p>We recorded the available clinical and biochemical data (e.g cortisol levels after 1mg dexamethasone suppression test, ACTH levels, urine free cortisol) of all patients with adrenal incidentalomas with and without mild autonomous cortisol secretion referred to the participating centres from January 1997 to June 2013. </p> <p> </p>
Correlation between diminished vagal tone and somatic dysfunction severity in very and extremely low birth weight preterm infants assessed with frequency spectrum heart rate variability and salivary cortisol
<p>Dataset</p>
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