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4,004
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4,004 results for “In vivo”
Optimization of an ex vivo gene transfer to the hamstrings tendons muscle remnants: potential for genetic enhancement of bone healing
<p>Human muscle tissue samples obtained from 31 patients was used in this in vitro analytical and experimental study. To optimize transduction protocol, samples from 28 patients were transduced with the adenoviral vector carrying firefly luciferase cDNA (Ad.luc) using different doses, times of transduction and addition of positive ions for transduction enhancement. The optimized protocol was further tested on muscle samples from 3 new patients, which were transduced with Ad.BMP-2. Released bone morphogenetic protein 2 (BMP-2) levels in osteogenic medium were measured every 3 days during the period of 21 days. Expression of osteogenic markers was at day 14 and 21. After 21 days of cultivation, muscle tissue was prepared for immunohistochemical staining for collagen type I (COL-I). </p>
Instalações VIVO
<p>Websites list for VIVO software instances</p>
Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo - Data Set 2
<p>The data set was analyzed in main figures 2, 3 and supplementary figure 5.</p>
Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo - Data Set 1
<p>24.01.2014 fish 5 was analyzed in main figures 1,2 and supplementary figure 4</p> <p>21.03.2014 fish 1 was analyzed in main figures 2,3 and supplementary figure 4</p>
dataset for root canal configuration of mandibular first and second premolars using in vivo cone-beam computed tomography imaging
<p>dataset for root canal configuration of mandibular first and second premolars using in vivo cone-beam computed tomography imaging</p>
MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles
<p>Dataset accompanying figures published in the publication DOI: 10.3390/bios8040127</p>
Fig. 2. A in Microstructural Impact of Ischemia and Bone Marrow-Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo
Fig. 2. A picture of four male - female pairs of Amblyomma variegatum attached on a cow examined during this survey. © Anne Laudisoit.
Fig. 1 in Microstructural Impact of Ischemia and Bone Marrow-Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo
Fig. 1. Map of Kisangani and Major transhumance routes from probable departure location to Kisangani city, DR Congo.
Xylitol is associated with cardiovascular event risks and enhances platelet responsiveness and thrombosis potential in vivo
Open the record for dataset details and reuse information.
Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications
Open the record for dataset details and reuse information.
Dataset for the article : Non-invasive estimation of in vivo optical properties and hemodynamic parameters of domestic animals: a preliminary study on horses, dogs, and sheep
<div> <div> <div> <div> </div> </div> </div> </div> <div> <div> <div> <div> <div> <div> <p>This dataset includes all the necessary data to understand and replicate the figures and tables presented in the article titled "Non-invasive Estimation of In Vivo Optical Properties and Hemodynamic Parameters of Domestic Animals: A Preliminary Study on Horses, Dogs, and Sheep." Specifically, it contains the raw measurement curves, along with the optical and hemodynamic parameters derived from the analysis of these raw data.</p> </div> </div> </div> </div> </div> </div>
Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair
<div> <p>Database for paper:</p> <p><a href="https://doi.org/10.7554/eLife.87949.2">doi.org/10.7554/eLife.87949.2</a></p> <p>The scripts for using our deep learning algrithm to detect cell divisions via a napari plugin can be found here:</p> <p>https://github.com/turleyjm/cell-division-dl-plugin</p> <p>The notebooks and analysis for training and evaluating the model are also given in this repository.</p> </div>
SESIÓN EN VIVO: LA CIENCIA Y SUS TENSIONES. ¿UN NUEVO CONTRATO SOCIAL? Doctor Hernán Jaramillo Salazar, Prof
<p>SESIÓN EN VIVO: LA CIENCIA Y SUS TENSIONES. ¿UN NUEVO CONTRATO SOCIAL? Doctor Hernán Jaramillo Salazar, Prof</p> <p>Presentación </p> <div> <div> <div> <div> <p>el concepto de un "nuevo contrato social de la ciencia", surgido de la Conferencia Mundial de la Ciencia en Budapest, que plantea una mayor vinculación de la investigación científica con las necesidades sociales. Se menciona la transición de la producción científica tradicional (modo 1), que se centra en disciplinas individuales y universidades, a una nueva forma (modo 2), que busca resolver problemas multidisciplinarios aplicando el conocimiento a situaciones concretas. Este cambio exige que los países en desarrollo combinen ambos enfoques, adaptándose a las nuevas demandas sociales y económicas, mientras mantienen altos estándares de calidad científica.</p> </div> </div> </div> </div> <p>Hernán Jaramillo Salazar & Manuel Rey, 2003. "<strong><a href="https://ideas.repec.org/p/col/000091/002947.html">La ciencia y sus tensiones: ¿un nuevo contrato social de la ciencia?</a></strong>," <a href="https://ideas.repec.org/s/col/000091.html">Borradores de Investigación</a> 2947, Universidad del Rosario. https://repository.urosario.edu.co/server/api/core/bitstreams/4fd8c77e-19c9-4332-8f01-cc78f38b3001/content </p>
Data from "GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes"
<p>Data from "GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes". Folders contain data corresponding to each figure. Additional readme files are included with each figure folder to explain the data contained there.</p>
Example dataset for in vivo blood sO2 imaging with ultrasound-aided large-scale optoacoustic microscopy
<p>"mouse1_r_5um_dualwave.mat" and "mouse1_r_10um_us.mat" contain the raw datasets in dual-wavelength optoacoustic and ultrasound modes acquired with ultrasound-aided large-scale optoacoustic microscopy on mouse dorsal skin.</p> <p>"mouse1_r.mat" contains the estimated skin surface based on the ultrasound dataset.</p> <p>After downloading the above 3 files, make a subfolder under the current working folder and name it "skinCropDepths", and put "mouse1_r.mat" under that subfolder.</p> <p>The code can be fetched from this Github repository: https://github.com/razanskylab/dualwaveProcessor. Refer to README file for explanation on the code base.</p> <p>The datasets shared here were acquired on healthy mouse dorsal skin and are intended for testing the unmixing scripts.</p> <p>The longitudinal datasets acquired during dorsal skin wound healing are too large to be publically shared, but is available for research purposes upon reasonable request: weiye.li@uzh.ch.</p> <p> </p> <p> </p>
In Vivo Rodent Cervicothoracic Vasculature Imaging Using Photoacoustic Computed Tomography
<p>These video clips are the supplementary video for the manuscript "<em>In Vivo</em> Rodent Cervicothoracic Vasculature Imaging Using Photoacoustic Computed Tomography" submitted to <em>Photonics</em>.</p>
Targeted genome editing in vivo corrects a Dmd duplication restoring wild‐type dystrophin expression
<p class="Paragraph">Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately, animal models recapitulating such mutations are scarce, limiting our ability to study them and develop genome editing-based therapies. Here, we describe the generation of the <em>Dup18-30 </em>mouse model, harbouring a multi-exonic tandem duplication in the <i>Dmd</i> gene which recapitulates a human mutation. Duplication correction of this mouse was achieved by implementing a single-guide RNA (sgRNA) CRISPR/Cas9 approach. This strategy precisely removed a duplication mutation <i>in vivo</i>, restored full-length dystrophin expression, and was accompanied by improvements in both histopathological and clinical phenotypes. We conclude that CRISPR/Cas9 represents a powerful tool to accurately model and treat tandem-duplication mutations. </p> <p class="Paragraph">This dataset includes the deep amplicon sequencing analysis performed to detect single-sgRNA/Cas9 off-target and on-target effects in the <em>Dup18-30</em> mice after treatment.</p>
Dataset for Subnormothermic ex vivo lung perfusion attenuates ischemia reperfusion injury from donation after circulatory death donors
<p>Use of normothermic <i>ex vivo</i> lung perfusion (EVLP) was adopted in clinical practice to assess the quality of marginal donor lungs. Subnormothermic perfusion temperatures are in use among other solid organs to improve biochemical, clinical and immunological parameters. In a rat EVLP model of donation after circulatory death (DCD) lung donors, we tested the effect of four subnormothermic EVLP temperatures that could further improve organ preservation. Warm ischemic time was of 2 hours. EVLP time was of 4 hours. Lung physiological data were recorded and metabolic parameters were assessed. Lung oxygenation at 21°C and 24°C were significantly improved whereas pulmonary vascular resistance and edema formation at 21°C EVLP were significantly worsened when compared to 37°C EVLP. The perfusate concentrations of potassium ions and lactate exiting the lungs with 28°C EVLP were significantly lower whereas sodium and chlorine ions with 32°C EVLP were significantly higher when compared to 37°C EVLP. Also compared to 37°C EVLP, the pro-inflammatory chemokines MIP2, MIP-1α, GRO-α, the cytokine IL-6 were significantly lower with 21°C, 24°C and 28°C EVLP, the IL-18 was significantly lower but only with 21°C EVLP and IL-1β was significantly lower at 21°C and 24°C EVLP. Compared to the 37°C EVLP, the lung tissue ATP content after 21°C, 24°C and 28°C EVLP were significantly higher, the carbonylated protein content after 28°C EVLP was significantly lower and we measured significantly higher myeloperoxidase activities in lung tissues with 21°C, 24°C and 32°C. The 28°C EVLP demonstrated acceptable physiological variables, significantly higher lung tissue ATP content and decreased tissue carbonylated proteins with reduced release of pro-inflammatory cytokines. In conclusion, the 28°C EVLP is a non inferior setting in comparison to the clinically approved 37°C EVLP and significantly improve biochemical, clinical and immunological parameters and may reduce I/R injuries of DCD lung donors.</p>
Data from: 7 Tesla MRI of the ex vivo human brain at 100 micron resolution
<p>We present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic resolution using a custom-built 31-channel receive array coil. Single-echo multi-flip Fast Low-Angle SHot (FLASH) data were acquired over 100 hours of scan time (25 hours per flip angle), allowing derivation of synthesized FLASH volumes. This dataset provides an unprecedented view of the three-dimensional neuroanatomy of the human brain. To optimize the utility of this resource, we warped the dataset into standard stereotactic space. We now distribute the dataset in both native space and stereotactic space to the academic community via multiple platforms. We envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance understanding of human brain anatomy in health and disease.</p>
Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM
<p>Macrophages (ΜΦs) are important immune effector cells that promote (M1 ΜΦs) or inhibit (M2 ΜΦs) inflammation and are involved in numerous physiological and pathogenic immune responses. Their precise role and relevance, however, are not fully understood for lack of non-invasive quantification methods. Here, we show that two-photon excited fluorescence lifetime imaging (TPE-FLIM), a label-free non-invasive method, can visualize ΜΦs in the human dermis in vivo. We demonstrate in vitro that human dermal ΜΦs exhibit specific TPE-FLIM properties that distinguish them from the main components of the extracellular matrix and other dermal cells. We visualized ΜΦs, their phenotypes and phagocytosis in the skin of healthy individuals in vivo using TPE-FLIM. Additionally, machine learning identified M1 and M2 MФs with a sensitivity of 0.88±0.04 and 0.82±0.03 and a specificity of 0.89±0.03 and 0.90±0.03, respectively. In clinical research, TPE-FLIM can advance the understanding of the role of MФs in health and disease.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.