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630
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ShareScore release 0.9.0
Dataset results
630 results for “Mycobacterium Tuberculosis”
Gene expression analysis of mouse alveolar macrophages infected with Mycobacterium tuberculosis isolated from BCG-vaccinated mice [balRNAseq]
GEO Series GSE212202. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis (ChIP-Seq)
GEO Series GSE242285. Mycobacterium tuberculosis H37Rv. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A multi-omics investigation into the mechanisms of hyper-virulence in Mycobacterium tuberculosis
GEO Series GSE203662. Mycobacterium tuberculosis. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome and chromatin accessibility mapping reveals a type I Interferon response triggered by Mycobacterium tuberculosis infection [ATAC-Seq]
GEO Series GSE211976. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome wide expession analysis of mouse bone marrow derive macrophage (Bmdm) cell stimulated with cytokine and infected with mycobacterium tuberculosis
GEO Series GSE56736. Mus musculus. 36 samples. Type: Expression profiling by array.
RNA Sequencing of macrophages harboring redox-diverse Mycobacterium tuberculosis.
GEO Series GSE283664. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A Novel Gene Regulates Vesiculogenesis and Immunomodulation in Mycobacterium tuberculosis
GEO Series GSE50050. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
GEO Series GSE54239. Mycobacterium tuberculosis H37Rv. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transciptomic changes in Mycobacterium tuberculosis (Mtb) infected hepatocytes at early and late time points of infection
GEO Series GSE256184. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic changes associated with deletion of Rv3143 from Mycobacterium tuberculosis H37Rv in relation to wild-type strain grown in 7H9/OADC medium
GEO Series GSE193950. Mycobacterium tuberculosis H37Rv. 6 samples. Type: Expression profiling by high throughput sequencing.
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis
GEO Series GSE267774. Homo sapiens. 3076 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterium tuberculosis transcription factor, EmbR regulates expression of virulence factors that aid in ex vivo and in vivo survival
GEO Series GSE154673. Mycobacterium tuberculosis. 8 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic control of replication, gene expression and growth phase by ADP-ribosylation of DNA in Mycobacterium tuberculosis [RNAseq_LogStationary]
GEO Series GSE283124. Mycobacterium tuberculosis. 16 samples. Type: Expression profiling by high throughput sequencing.
Accelerating early anti-TB drug discovery by creating mycobacterial indicator strains that predict mode of action [Mycobacterium tuberculosis]
GEO Series GSE107831. Mycobacterium tuberculosis H37Rv. 36 samples. Type: Expression profiling by high throughput sequencing.
Data from: Exposure to Mycobacterium tuberculosis during flexible bronchoscopy in patients with unexpected pulmonary tuberculosis
Objective: Recent guidelines recommend the use by healthcare personnel of a fit-tested N95 particulate respirator or higher-grade respiratory precaution in a patient undergoing bronchoscopy when pulmonary tuberculosis (PTB) is suspected. However, PTB may be unexpectedly diagnosed in this setting and therefore not evaluated, resulting in the unexpected exposure to Mycobacterium tuberculosis (MTB) of healthcare workers in the bronchoscopy suite. Here, we examined the incidence of unexpected exposure to MTB during flexible bronchoscopy and determined the exposure-related factors. Methods: Between 2011 and 2013, a retrospective study was conducted to evaluate unexpected diagnoses of PTB in the bronchoscopy suite. During the study period, 1650 consecutive patients for whom previous CT scans were available and who underwent bronchoscopy for respiratory disease other than PTB were included. The results of bronchial washing, bronchoalveolar lavage, and post-bronchoscopic sputum were reviewed. Results: PTB was unexpectedly diagnosed in 76 patients (4.6%). The presence of anthracofibrosis [odds ratio (OR), 3.878; 95% confidence interval (CI), 1.291–11.650; P = 0.016), bronchiectasis (OR, 1.974; 95% CI, 1.095–3.557; P = 0.024), or atelectasis (OR, 1.740; 95% CI, 1.010–2.903; P = 0.046) as seen on chest CT scan was independently associated with unexpected PTB. Patients with both anthracofibrosis and atelectasis were at much higher risk of unexpected PTB (OR, 4.606; 95% CI, 1.383–15.342; P = 0.013). Conclusions: The risk of MTB exposure by healthcare personnel in the bronchoscopy suite due to patients with undiagnosed PTB has been underestimated. Therefore, in geographic regions with an intermediate PTB prevalence, such as South Korea (97/100,000 persons per year), higher-grade respiratory precaution, such as a fit-tested N95 particulate respirator, should be considered to prevent occupational exposure to MTB during routine bronchoscopy, especially in patients with CT-confirmed anthracofibrosis, bronchiectasis, or atelectasis.
Data from: NK-CD11c+ cell crosstalk in diabetes enhances IL-6-mediated inflammation during mycobacterium tuberculosis infection
In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice. Levels of IL-6 also increased. Anti-IL-6 monoclonal antibody treatment of Mtb-infected acute- and chronic-T2DM mice increased survival (to 100%) and reduced pro- and anti-inflammatory cytokine expression. CD11c+ cells were the major source of IL-6 in Mtb-infected T2DM mice. Pulmonary natural killer (NK) cells in Mtb-infected T2DM mice further increased IL-6 production by autologous CD11c+ cells through their activating receptors. Anti-NK1.1 antibody treatment of Mtb-infected acute-T2DM mice increased survival and reduced pro- and anti-inflammatory cytokine expression. Furthermore, IL-6 increased inflammatory cytokine production by T lymphocytes in pulmonary tuberculosis patients with T2DM. Overall, the results suggest that NK-CD11c+ cell interactions increase IL-6 production, which in turn drives the pathological immune response and mortality associated with Mtb infection in diabetic mice.
Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis
<p>The repository contains the processed Seurat object generated from SELECT-seq data of ESAT-6/CFP-10-specific T cells sorted from PBMC of household contacts of sputum culture-positive cases of pulmonary TB (four subjects with latent TB infection (LTBI) and three <em>M. tuberculosis </em>'resisters' (RSTR)).</p> <p>Information on how the Seurat object was analyzed can be found in this GitHub respository: https://github.com/ttsunmeng/TB_RSTR_ESAT6CFP10_SelectSeq_analysis_pipeline.</p> <p>The full details of this cohort have been previously published here:</p> <ul> <li>Stein, C.M., et al. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda. Clin Infect Dis 68, 1705-1712 (2019).</li> <li>Stein, C.M., et al. Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. Am J Epidemiol 187, 1477-1489 (2018).</li> </ul>
A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis
ClinicalTrials.gov study NCT01600963. IPD Sharing: Not stated. Countries: 17. Publications: 0.
Clinical Trial to Evaluate the Efficacy and Safety of EEC for the Diagnosis of Mycobacterium Tuberculosis Infection in People Aged 3 Years and Above
ClinicalTrials.gov study NCT07152639. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Time-to-Detection in Culture of Mycobacterium Tuberculosis
ClinicalTrials.gov study NCT05568368. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.