Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,260
datasets available to search
ShareScore release 0.9.0
Dataset results
1,260 results for “Pharmacology”
Supplementary material 1 from: Kadushkin AG, Tahanovich AD, Movchan LV, Dziadzichkina VV, Levandovskaya OV, Shman TV (2022) Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease. Research Results in Pharmacology 8(1): 59-70. https://doi.org/10.3897/rrpharmacology.8.75467
Table S1
Papers 2022 . Research Group Pharmacology and Toxicology. University of Antioquia
<p>Papers 2022 . Research Group Pharmacology and Toxicology. University of Antioquia</p>
ASSESSMENT OF PHARMACOLOGICAL PROPERTIES OF A NEW PHYTOCOMPOSITION
Open the record for dataset details and reuse information.
Network pharmacology combined with gene chip to explore the targets of sanguinarine in ovarian cancer
Open the record for dataset details and reuse information.
ANALYSIS OF PHARMACOLOGICAL PROPERTIES OF ANTITUSSIVE DRUGS
Open the record for dataset details and reuse information.
Data from: Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors
S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate's action at AMPA receptors on human and rat receptors and was inactive at NMDA and kainate receptors. Potentiation did not differ among the different AMPA receptors subtypes (GluA1/2/4 flip and flop variants) (EC50 between 2.5–5.4 μM), except a higher EC50 value for GluA4 flop (0.7 μM) and a greater amount of potentiation on GluA1 flop. A low concentration of S 47445 (0.1 μM) decreased receptor response decay time of GluA1flop/GluA2flip AMPA receptors and increased the sensitivity to glutamate. Furthermore, S 47445 (0.1 and 0.3 μM) in presence of repetitive glutamate pulses induced a progressive potentiation of the glutamate-evoked currents from the second pulse of glutamate confirming a rapid-enhancing effect of S 47445 at low concentrations. The potentiating effect of S 47445 (1 μM) was concentration-dependently reversed by the selective AMPA receptor antagonist GYKI52466 demonstrating the selective modulatory effect of S 47445 on AMPA receptors. Using an AMPA-kainate chimera approach, it was confirmed that S 47445 binds to the common binding pocket of AMPA-PAMs. S 47445 did not demonstrate neurotoxic effect against glutamate-mediated excitotoxicity in vitro, in contrast significantly protected rat cortical neurons at 10 μM. S 47445 was shown to improve both episodic and spatial working memory in adult rodents at 0.3 mg/kg, as measured in the natural forgetting condition of object recognition and T-maze tasks. Finally, no deleterious effect on spontaneous locomotion and general behavior was observed up to 1000 mg/kg of S 47445 given acutely in rodents, neither occurrence of convulsion or tremors. Collectively, these results indicate that S 47445 is a potent and selective AMPA-PAM presenting procognitive and potential neuroprotective properties. This drug is currently evaluated in clinical phase 2 studies in Alzheimer's disease and in Major Depressive Disorder.
Figure 1 from: Pavliuk B, Stechyshyn I, Chubka M, Hroshovyi T (2021) Preclinical safety evaluation of drone brood homogenate and justification of pharmacological action. Pharmacia 68(4): 771-777. https://doi.org/10.3897/pharmacia.68.e70678
Figure 1 Relationships between metabolic syndrome, insulin resistance, pre-diabetes and type 2 diabetes mellitus.
Supplementary material 1 from: Indradi RB, Pitaloka DAE, Suryani (2022) Network pharmacology to uncover potential anti-inflammatory and immunomodulatory constituents in Curcuma longa rhizome as complementary treatment in COVID-19. Pharmacia 69(4): 995-1003. https://doi.org/10.3897/pharmacia.69.e89799
Datasets of Network Pharmacology Process
Supplementary material 1 from: Rahmadi M, Ardianto C, Nurhan AD, Chasanah RA, Krismonika DI, Puspitasari AD, Suprapti B, Segaran S, Phan C-W, Khotib J (2022) Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression. Research Results in Pharmacology 8(4): 65-75. https://doi.org/10.3897/rrpharmacology.8.82242
The representative photos of feces with high water content and low water content
Supplementary material 1 from: Kozuharova E, Simeonov V, Batovska D, Stoycheva C, Valchev H, Benbassat N (2023) Chemical composition and comparative analysis of lavender essential oil samples from Bulgaria in relation to the pharmacological effects. Pharmacia 70(2): 395-403. https://doi.org/10.3897/pharmacia.70.e104404
Lavender essential oil from Bulgaria and its pharmacological effects
Fig. 5 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 5. The mechanisms of anti-tumor activity of hyperforin.
Fig. 4 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 4. The mechanisms of anti-dementia activity of hyperforin.
Fig. 1 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 1. The structure of hyperforin.
Fig. 6 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 6. The mechanisms of immune regulatory and anti-inflammatory activity of hyperforin.
Fig. 3 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 3. The mechanisms of anti-depression activity of hyperforin.
Fig. 2 in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
Fig. 2. Structures of canthinone alkaloids isolated from P. quassioides.
Fig. 1 in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
Fig. 1. Structures of β-carboline alkaloids isolated from P. quassioides.
Fig. 4 in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
Fig. 4. The putative biosynthetic pathway of β-carboline and canthinone alkaloids.
Fig. 3 in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
Fig. 3. Structures of alkaloid dimers isolated from P. quassioide.
Fig. 7 in Carvone and its pharmacological activities: A systematic review
Fig. 7. Risk-of-bias assessment of the trials in vitro included in this systematic review.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.