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598
datasets available to search
ShareScore release 0.9.0
Dataset results
598 results for “Small molecules”
Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
GEO Series GSE176091. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Small-Molecule-Induced ERBB4 Activation to Treat Heart Failure
GEO Series GSE256024. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs with in vivo activity in hematological malignancies [RNA-Seq]
GEO Series GSE78930. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcoma.
GEO Series GSE283602. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Small molecules modulate chromatin accessibility to promote NEUROG2-mediated fibroblast-to-neuron reprogramming [ATAC-seq]
GEO Series GSE80639. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
HEK293T cells treated with a G9a small molecule inhibitor (UNC0638) or vehicle (DMSO), WIZ siRNA, G9a siRNA, or scrambled (control) siRNA
GEO Series GSE70914. Homo sapiens. 13 samples. Type: Expression profiling by array.
Small molecule-inducible RNA-targeting systems for temporal control of RNA regulation
GEO Series GSE149555. Homo sapiens. 2 samples. Type: Other.
RNA sequencing of PTEN,Rb1 double knockout (DKO) mouse prostate organoids treated with vehicle or the small molecule mitochondrial pyruvate carrier (MPC) inhibitor UK5099
GEO Series GSE221021. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Treatment of multiple myeloma cells with EZH2 small molecule inhibitor
GEO Series GSE57478. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Studying the selectivity of a targeted small molecule degrading a hypoxia-associated non-coding RNA
GEO Series GSE129307. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Chemo- versus immuno-precipitation of G-quadruplex-DNA (G4- DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture
GEO Series GSE200171. Oryza sativa. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation [RNA-Seq STM]
GEO Series GSE262731. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial small molecule treatment enhances the in vitro maturation of pluripotent stem cell-derived myotubes
GEO Series GSE130592. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Hijacking intrinsic resistance in Mycobacterium abscessus with small molecule prodrugs
GEO Series GSE273574. Mycobacteroides abscessus; Mycobacteroides abscessus ATCC 19977. 33 samples. Type: Expression profiling by high throughput sequencing.
Small-molecule-induced epigenetic rejuvenation overcomes myelinogenic barriers and stimulates myelin repair [HiChIP]
GEO Series GSE232954. Rattus norvegicus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Inhibition of CDK8/CDK19 with the small molecule inhibitor SEL120-34A in prostate cancer cell lines (3’ tag DGE)
GEO Series GSE269071. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition
GEO Series GSE51352. Homo sapiens. 36 samples. Type: Methylation profiling by genome tiling array.
Blockade of oncogenic IkappaB kinase activity in ABC DLBCL by small molecule BET protein inhibitors
GEO Series GSE58791. Homo sapiens. 12 samples. Type: Expression profiling by array.
Supporting video for "Temperature Modulated Micromechanical Thermal Analysis with Microstring Resonators Detects Multiple Coherent Features of Small Molecule Glass Transition"
<p>Supporting video for "Temperature Modulated Micromechanical Thermal Analysis with Microstring Resonators Detects Multiple Coherent Features of Small Molecule Glass Transition" . 720p Version. </p>
A small molecule that promotes cellular senescence prevents fibrogenesis and tumorigenesis
<p>Uncontrolled proliferative diseases such as fibrosis or cancer can be fatal. We previously found that a compound containing the chromone scaffold (SC), ONG41008, had potent anti-fibrogenic effects associated with EMT or cell cycle control resembling tumorigenesis. We investigated the effects of ONG41008 on tumor cells and compared these effects with those in pathogenic myofibroblasts. Stimulation of A549 (lung carcinoma epithelial cells) or PANC1 (pancreatic ductal carcinoma cells) with ONG41008 resulted in robust cellular senescence, indicating dysregulated cell proliferation is common to fibrotic cells and tumor cells. The senescence was followed by multinucleation, a manifestation of mitotic slippage. There were significant upregulation of expression and rapid nuclear translocation of p-TP53 and p16 in the treated cancer cells which thereafter died after 72hr confirmed by 6-day live imaging. ONG41008 exhibited a comparable senogenic potential to that of dasatinib. Interestingly, ONG41008 was only able to activate caspase3,7 in comparison with quercetin and fisetin also containing SC in A549. ONG41008 did not seem to be essentially toxic to normal human lung fibroblasts or primary prostate epithelial cells, suggesting ONG41008 can distinguish the intracellular microenvironment between normal cells and aged or diseased cells. This effect might occur as a result of the increased NAD/NADH ratio because ONG41008 restored this important metabolic ratio in cancer cells.</p> <p>Taken together, this is the first study to demonstrate that a small molecule can arrest uncontrolled proliferation during fibrogenesis or tumorigenesis via both senogenic and senolytic potential. ONG41008 could be a potential drug for a broad range of fibrotic or tumorigenic diseases.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.