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651 results for “autophagy”
An mRNA vaccine induces antimycobacterial immunity by activating DNA damage repair and autophagy
GEO Series GSE269547. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice
C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. Impaired autophagy is known to exacerbate renal ischemia-reperfusion injury (IRI). We examined whether the pathogenic role of CRP in AKI is associated with reduction of autophagy. We mated transgenic rabbit CRP over-expressing mice (Tg-CRP) with two autophagy reporter mouse lines, Tg-GFP-LC3 mice (LC3) and Tg-RFP-GFP-LC3 mice (RG-LC3) respectively to generate Tg-CRP-GFP-LC3 mice (PLC3) and Tg-CRP-RFP-GFP-LC3 mice (PRG-LC3). AKI was induced by IRI. Compared with LC3 mice, PLC3 mice developed more severe kidney damage after IRI. Renal tubules were isolated from LC3 mice at baseline for primary culture. OKP cells were transiently transfected with GFP-LC3 plasmid. CRP addition exacerbated lactate dehydrogenase release from both cell types. Immunoblots showed lower LC-3 II/I ratios and higher levels of p62, markers of reduced autophagy flux, in the kidneys of PLC3 mice compared to LC3 mice after IRI, and in primary cultured renal tubules and OKP cells treated with CRP and H2O2 compared to H2O2 alone. Immunohistochemistry showed much fewer LC-3 punctae, and electron microscopy showed fewer autophagosomes in kidneys of PLC3 mice compared to LC3 mice after IRI. Similarly, CRP addition reduced GFP-LC3 punctae induced by H2O2 in primary cultured proximal tubules and in GFP-LC3 plasmid transfected OKP cells. Rapamycin, an autophagy inducer, rescued impaired autophagy and reduced renal injury in vivo. In summary, it was suggested that CRP be more than mere biomarker in AKI, and render the kidney more susceptible to ischemic/oxidative injury, which is associated with down-regulating autophagy flux.
Autophagy Induction After Bortezomib for Myeloma
ClinicalTrials.gov study NCT01594242. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autophagy in Paediatric Crohn's Disease
ClinicalTrials.gov study NCT05842564. IPD Sharing: NO. Countries: 1. Publications: 0.
The Influence of Autophagy on Fatty Liver
ClinicalTrials.gov study NCT01988441. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients
ClinicalTrials.gov study NCT01292408. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autophagy and Inflammasome in Obesity: Effect of Weight Loss and Potential Therapeutic Implications
ClinicalTrials.gov study NCT05071391. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy of KH-1 for Stimulating Autophagy in Non-diabetic Adults With Elevated Blood Glucose Concentration
ClinicalTrials.gov study NCT06445569. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm
ClinicalTrials.gov study NCT03211000. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autophagy Maintenance (AUTOMAIN)
ClinicalTrials.gov study NCT06971744. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ezurpimtrostat Autophagy Inhibitor in Association With Atezolizumab-Bevacizumab in First Line Treatment of Unresectable Hepatocellular Carcinoma
ClinicalTrials.gov study NCT05448677. IPD Sharing: NO. Countries: 1. Publications: 0.
Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease
ClinicalTrials.gov study NCT05986136. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autophagy and Venous Endothelial Function
ClinicalTrials.gov study NCT04138134. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ethanol Induces Skeletal Muscle Autophagy
ClinicalTrials.gov study NCT03209791. IPD Sharing: NO. Countries: 1. Publications: 0.
Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma
ClinicalTrials.gov study NCT01510119. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MEK and Autophagy Inhibition in Metastatic/Locally Advanced, Unresectable Neuroblastoma RAS (NRAS) Melanoma
ClinicalTrials.gov study NCT03979651. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mitophagy and Autophagy in Elderly Subjects
ClinicalTrials.gov study NCT02472340. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine
ClinicalTrials.gov study NCT05421546. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chloroquine as an Anti-Autophagy Drug in Stage IV Small Cell Lung Cancer (SCLC) Patients
ClinicalTrials.gov study NCT00969306. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing Surgery or Active Surveillance
ClinicalTrials.gov study NCT02421575. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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