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2,967 results for “secondary”
Data from: Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progression
<p>Constitutive Androstane Receptor (CAR, <em>Nr1i3</em>), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid and lipid metabolizing enzymes, stimulates liver hypertrophy and hyperplasia, and ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to later disease development are poorly understood. Here we show that exposure of CD-1 mice to TCPOBOP, a halogenated xenochemical and selective CAR agonist ligand, induces pericentral steatosis marked by hepatic accumulation of cholesterol and neutral lipid, and elevated circulating alanine aminotransferase, indicating hepatocyte damage. TCPOBOP-induced steatosis was weaker in the pericentral region but stronger in the periportal region in females compared to males. Early (1-day) TCPOBOP transcriptional responses were enriched for CAR-bound primary response genes, and for lipogenesis and xenobiotic metabolism and oxidative stress protection pathways; late (2-wk) TCPOBOP responses included many CAR binding-independent secondary response genes, with enrichment for macrophage activation, immune response and cytokine and reactive oxygen species production. Late upstream regulators specific to TCPOBOP-exposed male liver were linked to pro-inflammatory responses and hepatocellular carcinoma progression. TCPOBOP administered weekly to male mice using a high corn oil vehicle activated carbohydrate-responsive transcription factor (MLXIPL)-regulated target genes, dysregulated mitochondrial respiratory and translation regulatory pathways, and induced more advanced liver pathology. Overall, TCPOBOP exposure recapitulates histological and gene expression changes characteristic of emerging steatotic liver disease, including secondary gene responses in liver non-parenchymal cells indicative of transition to a more advanced disease state. Upstream regulators of both the early and late TCPOBOP response genes include novel biomarkers for foreign chemical-induced metabolic dysfunction-associated steatotic liver disease.</p>
Secondary data_exploration depth and size of outside patch
<p>Dataset containing secondary data regarding cell distribution. This data was used for the generation the plots about cell distribution related to the article: <strong>The distinctive chemotactic responses of three marine herbivore protists to DMSP and related compounds.</strong> Therefore, provides information about the spatial distribution and the zones of accumulation of three cultured dinoflagellates (<em>Karlodinium armiger, Gyrodinium dominans</em> and<em> Oxyrrhis marina</em>) responding DMSP gradients diffusing from a microcapillary. </p> <p>Nomenclature:</p> <p>lambda_in: <span>the depth of exploration inside the capillary (λ<sub>in</sub>) </span></p> <p>lambda_out: <span>the size of the cell patch outside of it (λ<sub>out</sub>)</span></p> <p>concentration: uM</p>
Secondary data_Cell density distributions histograms
<p>Dataset containing secondary data regarding cell density. This data was used for the generation of histograms of cell density related to the article: <strong>The distinctive chemotactic responses of three marine herbivore protists to DMSP and related compounds.</strong> Therefore, provides information about the spatial distribution of three cultured dinoflagellates (<em>Karlodinium armiger, Gyrodinium dominans</em> and<em> Oxyrrhis marina</em>) responding to three chemical cues diffusing from a microcapillary. </p> <p>Nomenclature:</p> <p>bin_edge_um: spatial postion (um2) / counts: cell/um2 (density9 / concentration: uM</p>
Secondary_data_Maximum chemotactic indices (Icmax) to DMSP, DMS and acrylate
<p>Dataset containing secondary data regarding Chemotactic Indexes (Ic). This data was used for the generation the plot about Ic related to the article: <strong>The distinctive chemotactic responses of three marine herbivore protists to DMSP and related compounds.</strong> Therefore, provides information about the chemotaxis indexes obtained three cultured dinoflagellates (<em>Karlodinium armiger, Gyrodinium dominans</em> and<em> Oxyrrhis marina</em>) responding to gradients of DMSP, DMS and and acrylate diffusing from a microcapillary. </p> <p>Nomenclature:</p> <p>Cap: Capillary (C=control, E=experimental (with the chemical cue).</p> <p>D=DMSP/ M=DMS/ A=ACRYLATE</p> <p>2=2uM / 20= 20uM / 200= 200uM</p> <p>_1, _2, _3 = replicates 1, 2 or 3 </p>
Remagnetization of upper Triassic limestone from the central Lhasa terrane (Tibet): identification, mechanisms, and implications for diagnosing secondary remanent magnetization in carbonate rocks
<p>Raw data and supplementary material for manuscript titleted "Remagnetization of Upper Triassic limestone from the central Lhasa terrane (Tibet): identification, mechanisms, and implications for diagnosing secondary remanent magnetization in carbonate rocks".</p>
STING OPS: BJ1 Secondary Screen Single-Cell Features
<p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for BJ1 fibroblast secondary screen.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_BJ1.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p>
STING OPS: HeLa cGAMP (6 hours) Secondary Screen Single-Cell Features
<div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, 6 hours post-cGAMP, with or without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div>
STING OPS: HeLa Unstimulated Secondary Screen Single-Cell Features
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, unstimulated, without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div> <p> </p> </div>
STING OPS: HeLa Unstimulated Secondary Screen Single-Cell Features (Background-Subtracted)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, unstimulated, with rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div> <p> </p> </div>
STING OPS: HeLa cGAMP (4 hours) Secondary Screen Single-Cell Features
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, 4 hours post-cGAMP, with or without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
Fig. 2 in Formation Dynamics Of Herpetocomplexes On Sections Of Secondary Succession In Terrestrial Ecosystems Of Belarus
Fig. 2. Dynamics of number the herpetoсomplexes on the plots of secondary succession.
Biogenic secondary organic aerosol participates in plant interactions and herbivory defense
<p>Biogenic secondary organic aerosols (SOAs) can be formed from the oxidation of plant volatiles in the atmosphere. Herbivore-induced plant volatiles (HIPVs) can elicit plant defenses, but whether such ecological functions persist after they form SOAs was previously unknown. Here we show that Scots pine seedlings damaged by large pine weevils feeding on their roots release HIPVs that trigger defenses in neighboring conspecific plants. Interestingly, the biological activity persisted after HIPVs had been oxidized to form SOAs, which was indicated by receivers displaying enhanced photosynthesis, primed volatile defenses, and reduced weevil damage. The elemental composition and quantity of SOAs likely determines their biological functions. This work demonstrates that plant-derived SOAs can mediate interactions between plants, highlighting its ecological significance in ecosystems.</p>
GCK variants and their annotations for "Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes"
<p>This file provides annoatations for GCK variants as dsecribed in "Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes"</p>
Modelling Amorphization and Dissolution of Zr(Fe,Cr)2 Secondary Phase Precipitates in Zircaloys
<p>Data and accompanying paper "Modelling Amorphization and Dissolution of Zr(Fe,Cr)2 Secondary Phase Precipitates in Zircaloys" J. D. Robson, Journal of Nuclear Materials</p>
Рис. 2. Вторичный копуΛятивный аппарат самца Fig. 2. Secondary male genitalia in First record of the dragonfly Leucorrhinia albifrons (Burmeister, 1839) (Odonata: Libellulidae) in Yakutia
Рис. 2. Вторичный копуΛятивный аппарат самца Fig. 2. Secondary male genitalia
Determination of secondary species in solution through pump-selective transient absorption spectroscopy and explicit-solvent TDDFT
<p>Explicit and implicit solvent TDDFT of alizarin and tautomers of alizarin in methanol. Transient electronic absorption spectroscopy of alizarin in methanol at different pH values. </p>
Löhr-Limpens, M., Göhringer, F., Schenk, T., & Hesse, C. (2019). 'Grasping and perception are both affected by irrelevant information and secondary tasks: new evidence from the Garner paradigm'. Psychological Research. DOI: 10.1007/s00426-019-01151-z
<p>This repository contains 6 data files and one readme file describing the content of the data files.</p> <p> </p>
Predominance of Secondary Organic Aerosol to Particle-bound Reactive Oxygen Species Activity in Fine Ambient Aerosol
<p>Reactive oxygen species (ROS) are believed to contribute to the adverse health effects of aerosols. This may happen by inhaled particle-bound (exogenic) ROS (PB-ROS) or by ROS formed within the respiratory tract by certain aerosol components (endogenic ROS). We investigated the chemical composition of aerosols and their exogenic ROS content at the two contrasting locations Beijing (China) and Bern (Switzerland). We apportioned the ambient organic aerosol to different sources and attributed the observed water-soluble PB-ROS to them. The oxygenated organic aerosol (OOA, a proxy for secondary organic aerosol, SOA) explained the highest fraction of the exogenic ROS concentration variance at both locations. We also characterized primary and secondary aerosol emissions generated from different biogenic and anthropogenic sources in smog chamber experiments. The exogenic PB-ROS content in the OOA from these emission sources was comparable to that in the ambient measurements. Our results imply that SOA from gaseous precursors of different anthropogenic emission sources is a crucial source of water-soluble PB-ROS and should be additionally considered in toxicological and epidemiological studies in an adequate way besides primary emissions. The importance of PB-ROS may be connected to the seasonal trends in health effects of PM reported by epidemiological studies, with elevated incidences of adverse effects in warmer seasons, which are accompanied by more intense atmospheric oxidation processes.</p>
MORAL DEVELOPMENT AND APOROPHOBIA IN TEACHING IN PUBLIC SECONDARY SCHOOLS IN A PERUVIAN DISTRICT
<p><strong><span>Abstract</span></strong></p> <p><strong><span>Background:</span></strong><span> Aporophobia, or the rejection of the poor, has become increasingly relevant in contemporary societies, particularly amidst technological and communicational advancements. It is understood that this phenomenon often influences the moral development of individuals. Therefore, the research aims to determine whether the level of moral development correlates with aporophobic behavior among educators in public secondary educational institutions in the district of Abancay.</span></p> <p><strong><span>Methods: </span></strong><span>This research was of a basic-theoretical nature, employing a hypothetical-deductive, correlational approach with a quantitative, non-experimental, and cross-sectional design. The study involved 198 appointed teachers in the District of Abancay, using a questionnaire as the instrument.</span></p> <p><strong><span>Results: </span></strong><span>It was evident that the level of moral development significantly influences aporophobic behavior (Wald = 17.358; p = 0.000). Furthermore, significant correlations were identified between aporophobic behavior and the processes of socialization (Wald = 9.569; p = 0.000), preconventional moral development (Wald = 7.354; p = 0.008), and conventional moral development (Wald = 20.198; p = 0.000).</span></p> <p><strong><span>Conclusion: </span></strong><span>The level of moral development significantly impacts the aporophobic behavior of teachers in public secondary educational institutions in the district of Abancay.</span></p> <p><strong><span>Keywords: </span></strong><span>Rejection, discrimination, development, aporophobia, teachers</span><strong><span> </span></strong></p>
Fig. 1 in Camera Trapping The Indochinese Tiger, Panthera Tigris Corbetti, In A Secondary Forest In Peninsular Malaysia
Fig. 1. Map of FJB and infra red sensored camera locations.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.