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3,576 results for “strain”
The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (Rattus norvegicus) Wistar strain
<p>Raw data for manuscript with the title <strong>The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (<em>Rattus norvegicus</em>) Wistar strain </strong></p>
Second-strain gradient elasticity parameters for centrosymmetric materials
<p>This is a collection of material parameters sets describing 999, thermodynamically admissible, isotropic, centrosymmetric, elastic materials featuring second-strain gradient elasticity. The notations are according to Mindlin R.D. (1965) Second-gradient theory of strain and surface tension in linear elasticity. Int. J. Solids Structures<br> 1:417-438.</p>
Electrostatically Driven Polarization Flop and strain-induced Curvature in free-standing Ferroelectric Superlattices
<p>Supporting data for publication: "Electrostatically Driven Polarization Flop and strain-induced Curvature in free-standing Ferroelectric Superlattices"</p> <p>DOI: 10.1002/adma.202106826</p> <p>This repository contains higher resolution STEM images published in the paper.</p>
Long-read DNA-Seq of SmAP1 knockout strains
<p>Halobacterium salinarum knockout strains (delta-Ura3: control; delta-Ura3/delta-SmAP1: SmAP1 knockout) were cultured in uracil-supplemented (50 μg/mL) complex medium (CM) until mid-exponential phase (OD600nm = 0.5). The cultures were grown at 37C, under light exposure, and with constant agitation (125 RPM). We collected 2 mL samples and submitted them to DNA extraction using the DNeasy Blood & Tissue kit (QIAGEN), according to the manufacturer's instructions for Gram-negative bacteria. We tested DNA samples for purity and quantity using spectrophotometric and fluorimetric methods, respectively. The samples were prepared for long-read sequencing following the 1D native barcoding genomic DNA protocol using SQK-LSK108 and EXP-NBD103 (Oxford Nanopore Technologies). The equimolar pool of barcoded samples was sequenced using a MinION Mk1B instrument (Oxford Nanopore Technologies) in an FLO-MIN106 flow cell for 24 hours. Three biological replicates were sequenced for each one of the strains (control and SmAP1 knockout). This repository stores the partitioned (eleven parts: aa-ak) compressed directory (tar.gz) containing all the raw reads (fast5 format) output by the MinKNOW software.</p> <p><strong>Experimental design:</strong></p> <table> <tbody> <tr> <td><strong>Barcode</strong></td> <td><strong>Description</strong></td> </tr> <tr> <td>Barcode 01</td> <td>Control, biological replicate 1</td> </tr> <tr> <td>Barcode 02</td> <td>Control, biological replicate 2</td> </tr> <tr> <td>Barcode 03</td> <td>Control, biological replicate 3</td> </tr> <tr> <td>Barcode 04</td> <td>SmAP1 knockout, biological replicate 1</td> </tr> <tr> <td>Barcode 05</td> <td>SmAP1 knockout, biological replicate 2</td> </tr> <tr> <td>Barcode 06</td> <td>SmAP1 knockout, biological replicate 3</td> </tr> </tbody> </table> <p><strong>Instructions to merge files and extract:</strong></p> <p>1. Download all the files available in this Zenodo entry (smap1_ko_exp_fast5.tar.gz.part_a*; from aa to ak; eleven files) to your preferred directory;</p> <p>2. Execute the following commands using a Linux or OSX terminal:</p> <pre><code class="language-bash"># concatenate all the files into a single one cat smap1_ko_exp_fast5.tar.gz.part_a* > smap1_ko_exp_fast5.tar.gz # extract the merged file tar zxvf smap1_ko_exp_fast5.tar.gz</code></pre> <p> </p>
Large-scale fungal strain sequencing unravels the molecular diversity in mating loci maintained by long-term balancing selection
<p><span>Balancing selection, an evolutionary force that retains genetic diversity, has been detected in multiple genes and organisms, such as the sexual mating loci in fungi. However, to quantify the strength of balancing selection and define the mating-related genes require a large number of strains. In tetrapolar basidiomycete fungi, sexual type is determined by two unlinked loci, <em>MATA </em>and <em>MATB</em>. Genes in both loci define mating type identity, control successful mating and completion of the life cycle. These loci are usually highly diverse. Previous studies have speculated, based on culture crosses, that species of the non-model genus <em>Trichaptum </em>(Hymenochaetales, Basidiomycota) possess a tetrapolar mating system, with multiple alleles. Here, we sequenced a hundred and eighty strains of three <em>Trichaptum </em>species. We characterized the chromosomal location of <em>MATA </em>and <em>MATB</em>, the molecular structure of <em>MAT </em>regions and their allelic richness. The sequencing effort was sufficient to molecularly characterize multiple <em>MAT </em>alleles segregating before the speciation event of <em>Trichaptum </em>species. Analyses suggested that long-term balancing selection has generated trans-species polymorphisms. Mating sequences were classified in different allelic classes based on an amino acid identity (AAI) threshold supported by phylogenetics. 17,550 mating types were predicted based on the allelic classes. <em>In vitro </em>crosses allowed us to support the degree of allelic divergence needed for successful mating. Even with the high amount of divergence, key amino acids in functional domains are conserved. We conclude that the genetic diversity of mating loci in <em>Trichaptum </em>is due to long-term balancing selection, with limited recombination and duplication activity. The large number of sequenced strains highlighted the importance of sequencing multiple individuals from different species to detect the mating-related genes, the mechanisms generating diversity and the evolutionary forces maintaining them.</span></p>
Raw Data for the article: Usefulness of longitudinal systolic strain and delayed enhancement cardiac magnetic resonance in depicting risk of supraventricular arrythmias in patients with acute myocarditis and preserved left ventricular function
<p><strong>Background: </strong>Myocarditis have variable clinical presentation, evolution and prognosis. Aim of our study was to evaluate the value of speckle tracking echocardiography and cardiac magnetic resonance (CMR) in the short-term prediction of supraventricular arrhythmias (SVA) in patients with acute myocarditis.</p> <p><strong>Methods: </strong>Seventy patients (mean age 31±14 years old) with acute myocarditis and preserved left ventricular ejection fraction (LVEF) were enrolled. Longitudinal systolic strain (LS) of the left ventricle (LV), mechanical dispersion (MD) and CMR with quantitative measurement of delayed enhancement (DE) were performed in a subset of 43 patients. Logistic regression and ROC analysis were used to identify predictors of SVA RESULTS: Only LS measured at sup-epicardial, mid-wall and sub-endocardial level of the apical 4-chamber view was significantly lower in patients with SVA, while MD was marginally prolonged in this setting. A value of LS > - 16.1% measured at LV mid-wall in the apical 4-chamber view (ROC-AUC .75, Sensitivity 63%, Specificity 85%) was the most accurate measure to identify patients with SVA. DE mass was also helpful with a ROC-AUC .76; a DE-Mass > 18.9 gr. had a Sensitivity 63% and a Specificity 77%, to identify patients at risk of SVA.</p> <p><strong>Conclusions: </strong>Both DE mass and LS were associated with higher risk of SVA in patients with acute myocarditis and preserved LVEF. However, LS measured at the mid-wall level and limited to LV segments included in the apical 4-chamber view was the most accurate measure and did not show interaction with DE mass.</p>
Processed MinION genome sequencing data for strains ILHA G3AG5 and ILHA G3AA5
<p>Strain G3AA5 datasets include:</p> <p>Galaxy2750, Galaxy2754, Galaxy3522, Galaxy3523, Galaxy3524, Galaxy3541</p> <p> </p> <p>Strain G3AG4 datasets include:</p> <p>Galaxy2404, Galaxy2408, Galaxy3517, Galaxy3518, Galaxy3519, Galaxy3539</p>
Genome and gene annotation for yeast strain SK1 used in "Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling"
<p>Genome and gene annotation used in "Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling" provided by Schraga Schwartz from his time at the Broad Institute.</p>
Hydractinia strain 236-21 genome assembly and Alr domain predictions
<p>This dataset is related to the preprint "A family of unusual A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex" (<a href="https://www.biorxiv.org/content/10.1101/2022.03.04.482883v2">https://www.biorxiv.org/content/10.1101/2022.03.04.482883v2</a>).</p> <p><strong>Preprint Abstract:</strong></p> <p>Most colonial marine invertebrates are capable of allorecognition, the ability to distinguish between themselves and conspecifics. One long-standing question is whether invertebrate allorecognition genes are homologous to vertebrate histocompatibility genes. In the cnidarian <em>Hydractinia symbiolongicarpus, </em>allorecognition is controlled by at least two genes, <em>Allorecognition 1</em> (<em>Alr1</em>) and <em>Allorecognition 2 </em>(<em>Alr2</em>), which encode highly polymorphic cell surface proteins that serve as markers of self. Here, we show that <em>Alr1</em> and <em>Alr2</em> are part of a family of 41 <em>Alr </em>genes, all of which reside a single genomic interval called the Allorecognition Complex (ARC). Using sensitive homology searches and highly accurate structural predictions, we demonstrate that the Alr proteins are members of the immunoglobulin superfamily (IgSF) with V-set and I-set Ig domains unlike any previously identified in animals. Specifically, their primary amino acid sequences lack many of the motifs considered diagnostic for V-set and I-set domains, yet they adopt secondary and tertiary structures nearly identical to canonical Ig domains. Thus, the V-set domain, which played a central role in the evolution of vertebrate adaptive immunity, was present in the last common ancestor of cnidarians and bilaterians. Unexpectedly, several Alr proteins also have immunoreceptor tyrosine-based activation motifs (ITAMs) and immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic tails, suggesting they could participate in pathways homologous to those that regulate immunity in humans and flies. This work expands our definition of the IgSF with the addition of a family of unusual members, several of which play a role in invertebrate histocompatibility.</p> <p><strong>This dataset contains:</strong></p> <ol> <li><strong>Hsym-236-21-genome-assembly.fa.gz</strong>: A gzip-compressed FASTA-formatted file of the genome assembly generated in the paper. </li> <li><strong>Alr-domain-structure-predictions.zip:</strong> a zip-compressed file with structural predictions produced with Colabfold for all domains of the Alr proteins described in that manuscript.</li> </ol>
Strain specific genome scale metabolic models for 1011 Saccharomyces cerevisiae
<p>This is generated strain-specific genome scale metabolic models for 1011 S.cerevisiae. This is linked with the paper: Lu, H. et al. <em>A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism.</em> Nature Communications 10, 3586 (2019). <a href="https://doi.org/10.1038/s41467-019-11581-3">doi:10.1038/s41467-019-11581-3</a></p>
Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage ΦD5 results in fitness tradeoffs for the bacterium during infection - microscopic dataset
<p>Microscopic datasets (TEM, SEM and AFM) supporting the manuscript entitled: <strong>Resistance of </strong><em><strong>Dickeya solani</strong></em><strong> strain IPO 2222 to lytic bacteriophage </strong><strong>Φ</strong><strong>D5 results in fitness tradeoffs for the bacterium during infection.</strong></p>
Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage ΦD5 results in fitness tradeoffs for the bacterium during infection - mutants genomes dataset
<p>Raw genome sequence (genomes of the phage-resistant D. solani Tn5 mutants) dataset supporting the manuscript entitled: <strong>Resistance of </strong><em><strong>Dickeya solani</strong></em><strong> strain IPO 2222 to lytic bacteriophage </strong><strong>Φ</strong><strong>D5 results in fitness tradeoffs for the bacterium during infection.</strong></p>
Full-field displacements and strains obtained by digital image correlation during fatigue crack growth experiments
<p>This data publication contains full-field displacements and strains obtained by 3D digital image correlation (DIC) using a GOM Aramis 12M system including three fatigue crack propagation (fcp) experiments of AA2024-T3 aluminium sheet material.</p> <p>The repository consists of three datasets of different experiments named </p> <ul> <li>S<sub>950,1.6 </sub>- MT950 specimen, 1.6 mm sheet thickness, load ratios R=0.3, 1.0</li> <li>S<sub>160,2.0 </sub>- MT160 specimen, 2.0 mm sheet thickness, load ratios R=0.1, 0.25, 0.5, 0.75, 1.0</li> <li>S<sub>160,4.7 </sub>- MT160 specimen, 4.7 mm sheet thickness, load ratios R=0.1, 0.25, 0.5, 0.75, 1.0</li> </ul> <p>where S<sub>w,t</sub> denotes a middle tension (MT) specimen with width w and thickness t. The nodal DIC measurements at different times during the experiments are provided as .txt files we call <em>"nodemaps" </em>and stored in subfolders "<strong>Nodemaps</strong>". Each <em>nodemap</em> consists of a header containing meta data information like a running number (current stage index) or the applied force, followed by the nodal displacements and strains in tabular form. Additionally, the dataset S<sub>160,4.7</sub> contains crack path and crack tip labels for each nodemap in the subfolder "<strong>GroundTruth</strong>". The ground truth is provided as arrays of size 256x256. Each pixel of the array contains the label "2" for the class "crack tip", "1" for the class "crack path", or "0" for the class "background". These labels were created in a semi-manual fashion and can be used for machine learned crack detection using supervised training.</p> <p>These datasets were recently used to evaluate neural attention of convolutional neural networks trained on fatigue crack tip detection in <a href="https://www.nature.com/articles/s41598-022-13275-1">Melching et al. (Sci Rep, 2022)</a>. Additional guidance on data loading and usage can also be found at <a href="https://github.com/dlr-wf/explainable-crack-tip-detection">https://github.com/dlr-wf/explainable-crack-tip-detection</a>.</p> <p>The experiments S<sub>160,2.0</sub> and S<sub>160,4.7 </sub>were conducted and analysed by <a href="https://doi.org/10.1111/ffe.13433">Strohmann et al. (FFEMS, 2021)</a>.</p> <p>The experiment S<sub>950,1.6</sub> was conducted and analysed by <a href="https://doi.org/10.1111/ffe.13335">Breitbarth et al. (FFEMS, 2020)</a>.</p>
Data from: Bighorn sheep show similar in-host responses to the same pathogen strain in two contrasting environments
<p>Ecological context – the biotic and abiotic environment, along with its influence on population mixing dynamics and individual susceptibility – are thought to have major bearing on epidemic outcomes. However, direct comparisons of disease events in contrasting ecological contexts in wildlife systems are often confounded by concurrent differences in host genetics, exposure histories, or pathogen strains. Here, we compare disease dynamics of a <em>Mycoplasma ovipneumoniae</em> spillover event that affected bighorn sheep populations in two contrasting ecological contexts. One event occurred on the herd's home range near the Rio Grande Gorge in New Mexico, while the other occurred in a captive facility at Hardware Ranch in Utah. While data collection regimens varied between the two sites, general patterns of antibody signal strength and symptom emergence were consistent. Symptoms appeared in the captive setting an average of 12.9 days post-exposure, average time to seroconversion was 24.9 days, and clinical signs peaked at approximately 36 days post-infection. These patterns were consistent with serological testing and subsequent declines in symptom intensity in the free-ranging herd. At the captive site, older animals exhibited more severe declines in body condition and loin thickness, higher symptom burdens, and slower antibody response to the pathogen than younger animals.<span class="Apple-converted-space"> </span>Younger animals were more likely than older animals to clear infection by the time of sampling at both sites. The patterns presented here suggest that environment may not be a major determinant of epidemiological outcomes in the bighorn sheep - <em>M. ovipneumoniae</em> system, elevating the possibility that host- or pathogen-factors may be responsible for observed variation.</p>
Finite-strain Visco-elastic Visco-plastic model identification of PA12 material printed along different directions
<p>The data provide the identification of PA12 bulk material for a finite-strain visco-elastic-visco-plastic (VE-VP) model printed along two directions.</p> <p>Tests were conducted in L. Cobian, M. Rueda-Ruiz, J.P. Fernandez-Blazquez, V. Martinez, F. Galvez, F. Karayagiz, T. Lück, J. Segurado, M.A. Monclus, Micromechanical characterization of the material response in a PA12-SLS fabricated lattice structure and its correlation with bulk behaviour, Polymer Testing 110 (2022) 107556: <a href="https://doi.org/10.1016/j.polymertesting.2022.107556">https://doi.org/10.1016/j.polymertesting.2022.107556</a> (in Open access), see also <a href="http://dx.doi.org/10.5281/zenodo.6136935">http://dx.doi.org/10.5281/zenodo.6136935</a> (in Open access)</p> <p>Material model follows V. D. Nguyen, F. Lani, T. Pardoen, X. Morelle, L. Noels, A large strain hyperelastic viscoelastic-viscoplastic-damage constitutive model based on a multi-mechanism non-local damage continuum for amorphous glassy polymers. International Journal of Solids and Structures 96 (2016): 192-216; <a href="https://dx.doi.org/10.1016/j.ijsolstr.2016.06.008">https://dx.doi.org/10.1016/j.ijsolstr.2016.06.008</a>, Open access: <a href="https://orbi.uliege.be/handle/2268/197898">https://orbi.uliege.be/handle/2268/197898</a>.</p> <p>The model</p> <ul> <li>Is implemented as a cross platform UMAT subroutine that is openly available on <a href="https://gitlab.uliege.be/moammm/moammmpublic/-/tree/master/code/MaterialModels/FiniteStrain/Finite_VEVP">https://gitlab.uliege.be/moammm/moammmpublic/-/tree/master/code/MaterialModels/FiniteStrain/Finite_VEVP</a> (Licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) (<a href="https://creativecommons.org/licenses/by/4.0">https://creativecommons.org/licenses/by/4.0</a>).) and referenced on the project web-site <a href="https://www.moammm.eu/index.php/developed-code/">https://www.moammm.eu/index.php/developed-code/</a>.</li> <li>The model is also implemented at the cm3 laboratory, who provides efficient algorithms for homogenisation implemented in a parallel setting in the open source finite element code base on <a href="http://gmsh.info/">Gmsh</a>. In order to have access to the sources follows <a href="https://www.moammm.eu/index.php/developed-code/">https://www.moammm.eu/index.php/developed-code/</a>.</li> </ul> <p>If you use these data or model, we would be grateful if you could cite the related papers:</p> <ul> <li>L. Cobian, M. Rueda-Ruiz, J.P. Fernandez-Blazquez, V. Martinez, F. Galvez, F. Karayagiz, T. Lück, J. Segurado, M.A. Monclus, Micromechanical characterization of the material response in a PA12-SLS fabricated lattice structure and its correlation with bulk behaviour, Polymer Testing 110 (2022) 107556: https://doi.org/10.1016/j.polymertesting.2022.107556 (in Open access)</li> <li>Data of “. Cobian, M. Rueda-Ruiz, J.P. Fernandez-Blazquez, V. Martinez, F. Galvez, F. Karayagiz, T. Lück, J. Segurado, M.A. Monclus, Micromechanical characterization of the material response in a PA12-SLS fabricated lattice structure and its correlation with bulk behaviour, Polymer Testing 110 (2022) 107556” http://dx.doi.org/10.5281/zenodo.6136935 (in Open access)</li> <li>V. D. Nguyen, F. Lani, T. Pardoen, X. Morelle, L. Noels, A large strain hyperelastic viscoelastic-viscoplastic-damage constitutive model based on a multi-mechanism non-local damage continuum for amorphous glassy polymers. International Journal of Solids and Structures 96 (2016): 192-216; https://dx.doi.org/10.1016/j.ijsolstr.2016.06.008, Open access: https://orbi.uliege.be/handle/2268/197898</li> </ul> <p>This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862015</p>
Beyond bold versus shy: Zebrafish exploratory behavior falls into several behavioral clusters and is influenced by strain and sex
<p>Individual differences in exploratory behavior have been found across a range of taxa and are thought to contribute to evolutionary fitness. Animals that explore more of a novel environment and visit areas of high predation risk are considered bold, whereas animals with the opposite behavioral pattern are shy. Here, we determined whether this bimodal characterization of bold versus shy adequately captures the breadth of behavioral variation in zebrafish or if there are more than these two subtypes. To identify behavioral categories, we applied unsupervised machine to three-dimensional swim traces from over 400 adult zebrafish across four strains (AB, TL, TU, and WIK) and both sexes. We found that behavior stratified into four distinct clusters: previously described bold and shy behavior and two new behavioral types we call wall-huggers and active explorers. Clusters were stable across time and influenced by strain and sex where we found that TLs were shy, female TU fish were bold, male TU fish were active explorers, and male ABs were wall-huggers. Our work suggests that zebrafish exploratory behavior has greater complexity than previously recognized and lays the groundwork for the use of zebrafish in understanding the biological basis of individual differences in behavior.</p>
Draft Genome sequencing of Nocardia sp. strain WB46 Isolated from Salix purpurea Growing in a Site Chronically Contaminated by Petroleum Hydrocarbons
<p>Assembled contigs of the genome of <em>Nocardia</em> sp. strain WB46 isolated from <em>the rhizosphere of Salix purpurea </em>growing in a site chronically contaminated by petroleum hydrocarbons located at Varennes, Qubec, Canada.</p>
Enterobacter cloacae complex (E. bugandensis species, ST599) strain associated with a catheter-related bloodstream infection (CRBSI) (genome assembly and annotation dataset)
<p>This dataset includes the assembled contigs (.fasta and .gbk files), the nucleotide sequences of the prediction transcripts (.ffn files) and the respective amino acid sequences of the translated CDS sequences (.faa files) of a <em><strong>Enterobacter cloacae </strong></em><strong>complex</strong><em><strong> (E. bugandensis </strong></em><strong>species</strong><em><strong>, </strong></em><strong>ST599</strong><em><strong>) </strong></em>strain associated with a catheter-related bloodstream infection (CRBSI) (genome anotation was performed using Prokka v1.14.5; https://github.com/tseemann/prokka)</p> <p>The raw sequence reads were deposited in the European Nucleotide Archive (ENA) (BioProject PRJEB45360; Run Accession: ERR10044433).</p>
Data for the article "Effective strain manipulation of the antiferromagnetic state of polycrystalline NiO"
<p>Data for the article "Effective strain manipulation of the antiferromagnetic state of polycrystalline NiO"</p> <p>(<a href="https://aip.scitation.org/doi/abs/10.1063/5.0046255">https://aip.scitation.org/doi/abs/10.1063/5.0046255</a> and <a href="https://arxiv.org/abs/2105.13653">https://arxiv.org/abs/2105.13653</a>)</p> <p> </p> <p>Barra, Andrew Ross, Olena Gomonay, Lorenzo Baldrati, A Chavez, Romain Lebrun, JD Schneider, Paymon Shirazi, Q Wang, Jairo Sinova, Gregory P Carman, Mathias Kläui</p>
DNA Methyltransferase regulates nitric oxide homeostasis and virulence in a chronically adapted Pseudomonas aeruginosa strain
<p><span>Opportunistic pathogens such as <em>Pseudomonas aeruginosa </em>adapt their genomes rapidly during chronic infections. Understanding their epigenetic regulation may provide biomarkers for diagnosis and reveal novel regulatory mechanisms. We performed single-molecule real-time sequencing (SMRT-seq) to characterize the methylome of a chronically adapted P. aeruginosa clinical strain TBCF10839. Two </span><span>N6-methyl-adenine (6mA) methylation recognition motifs (RCC<strong>A</strong>NNNNNNN<strong>T</strong>GAR and </span><span>TRG<strong>A</strong>NNNNNN<strong>T</strong>GC)</span><span> were identified and predicted as </span><span>new type I methylation sites using REBASE analysis. We confirmed that motif </span><span>TRG<strong>A</strong>NNNNNN<strong>T</strong>GCwas methylated by MTase M.PaeTBCFII, according to methylation sensitivity assays <em>in vivo </em>and <em>vitro</em>. Transcriptomic analysis showed that <em>Δ</em></span><em><span>M.PaeTBCFII</span></em><span><em> </em>knockout mutant significantly downregulated nitric oxide reductase (NOR) regulating and coding gene expression such as </span><span>nosR </span><span>and norB,</span><span> which contain</span><span> methylated motifs in their promoters or coding regions.</span><span> Δ</span><span>M.PaeTBCFII </span><span>exhibited </span><span>reduced intercellular survival capacity in NO-producing RAW 264.7 macrophages and attenuated virulence in <em>Galleria mellonella</em> infection model; the </span><span>complemented strain recovered these defective phenotypes</span><span>. Further phylogenetic analysis demonstrated that homologs of M.PaeTBCFII occur frequently in P. aeruginosa sp as well as other bacterial species. Our work therefore provided new insights on the relationship between DNA methylation, NO detoxification, and bacterial virulence, </span><span>laying a foundation for further exploring the molecular mechanism of DNA methyltransferase in regulating the pathogenicity of <em>P. aeruginosa</em></span><span>.</span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.