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3,476 results for “Parkinsons Disease”
Data associated to the study entitled:"Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI"
<p>Parkinson’s disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology.</p> <p>We performed a unilateral injection of 6-OHDA in the striatum of Sprague Dawley rats to produce retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta. We carried out a longitudinal study with a multi-modal approach combining structural and functional MRI together with quantitative histological validation to follow the effects of the lesion. Functional and structural connectivity were assessed in the brain of 6-OHDA rats and sham rats (NaCl injection) at 3 and 6 weeks post-lesioning using resting-state functional MRI and diffusion-weighted.</p> <p>The shared datafile corresponds to the MRI biomarkers extracted from diffusion and functional acquisitions as well as from histological mesaurements within striatum and substantia nigria.</p>
Data from: Axial symptoms predict mortality in patients with Parkinson disease with subthalamic stimulation
Objective: To characterize how disease progression is associated with mortality in a large cohort of PD patients with long-term follow-up after STN-DBS. Methods: Motor and cognitive disabilities were assessed before, and 1, 2, 5 and 10 years after STN-DBS in 143 consecutive PD patients. We measured motor symptoms Off and On levodopa and STN-DBS, and recorded causes of death. We used linear mixed-models to characterize symptom progression, including interactions between treatment conditions and time to determine how treatments changed efficacy. We used joint models to link progression to mortality. Results: Median observation time was 12 years after surgery, during which akinesia, rigidity and axial symptoms worsened, with mean increases of 8.8 (SD 6.5), 1.8 (3.1) and 5.4 (4.1) points from year 1 to 10 after surgery (On dopamine/On STN-DBS), respectively. Responses to dopaminergic medication and STN-DBS were attenuated with time, but remained effective for all except axial symptoms, for which both treatments and their combination were predicted to be ineffective 20 years after surgery. Cognitive status significantly declined. Forty-one patients died with a median time to death of 9 years after surgery. The current level of axial disability was the only symptom that significantly predicted death (HR=4.30 [SE 1.50] per unit of square-root transformed axial score). Conclusions: We quantified long-term symptom progression and attenuation of dopaminergic medication and STN-DBS treatment efficacy in PD patients, and linked symptom progression to mortality. Axial disability significantly predicts individual risk of death after surgery, which may be useful for planning therapeutic strategies in PD.
Data from: Substantia nigra integrity correlates with sequential working memory in Parkinson's disease
<p>Maintaining and manipulating sequential information online is essential for daily activities such as planning. In Parkinson's disease (PD), deficits in sequential working memory have been associated with altered regional activation and functional connectivity within the basal ganglia. This study demonstrated that the substantia nigra (SN) integrity correlates with basal ganglia dysfunction during sequential working memory. We included 29 patients with PD and 29 healthy controls (HC). We assessed the SN integrity using neuromelanin-sensitive MRI and sequential working memory using functional MRI and a digit ordering task. In this task, participants either recalled a sequence of digits in the original order ('pure recall') or rearranged the digits in ascending order and recalled the new sequence ('reorder & recall'). PD showed smaller SN areas than HC, especially on the left side. Compared to HC, PD showed lower task accuracy, hyper-activation of the subthalamic nucleus, hypo-activation of the caudate nucleus and globus pallidus, and weakened functional connectivity between the bilateral SN and all three basal ganglia regions. Moreover, PD showed distinct brain-behavior and structure-function relationships. Ordering-related accuracy cost ('reorder & recall' <i>versus</i> 'pure recall') correlated with the ordering-related subthalamic activation in HC, but with the ordering-related caudate activation in PD. In PD, the caudate activation correlated with the total SN area, whereas the subthalamic activation correlated with daily exposure to D2/3 receptor agonists. In conclusion, damage to the SN may lead to basal ganglia dysfunction sequential working memory deficits even in early PD.</p>
Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures--Gene Validation FCS
<p>FCS files corresponding to the gene validation experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures"</p> <p>Funding provided in part by the Aligning Science Across Parkinson’s ASAP-000375</p>
A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation
<p>Deep brain stimulation (DBS) is indicated when motor disturbances in patients with idiopathic Parkinson's disease (PD) are refractory to current treatment options and significantly impair quality of life. However, post-DBS rehabilitation is essential, with particular regard to gait. Rhythmic auditory stimulation (RAS)-assisted treadmill gait rehabilitation within conventional physiotherapy program plays a major role in gait recovery. We explored the effects of a monthly RAS-assisted treadmill training within a conventional physiotherapy program on gait performance and gait-related EEG dynamics (while walking on the RAS-aided treadmill) in PD patients with (<em>n</em> = 10) and without DBS (<em>n</em> = 10). Patients with DBS achieved superior results than those without DBS concerning gait velocity, overall motor performance, and the timed velocity and self-confidence in balance, sit-to-stand (and vice versa) and walking, whereas both groups improved in dynamic and static balance, overall cognitive performance, and the fear of falling. The difference in motor outcomes between the two groups was paralleled by a stronger remodulation of gait cycle-related beta oscillations in patients with DBS as compared to those without DBS. Our work suggests that RAS-assisted gait training plus conventional physiotherapy is a useful strategy to improve gait performance in PD patients with and without DBS. Interestingly, patients with DBS may benefit more from this approach owing to a more focused and dynamic re-configuration of sensorimotor network beta oscillations related to gait secondary to the association between RAS-treadmill, conventional physiotherapy, and DBS. Actually, the coupling of these approaches may help restoring a residually altered beta-band response profile despite DBS intervention, thus better tailoring the gait rehabilitation of these PD patients.</p>
DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease
<p>Raw data sets for the manuscript "<strong>DOPA pheomelanin is increased in nigral neuromelanin of Parkinson’s disease"</strong></p>
Apathy and impulsiveness in Parkinson's disease: Two faces of the same coin?
<p>Apathy and impulsiveness are 2 common non-motor symptoms in Parkinson disease that could occur in different periods or simultaneously. Apathy and impulsiveness could be interpreted as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, in which, impulsivity, is a result of a hyperdopaminergic state, whereas apathy is viewed as a hypodopaminergic. The study aimed to investigate the presence of impulsiveness and other neuropsychiatric symptoms in Parkinson disease patients with apathy symptoms. Eighty-one patients with Parkinson disease were enrolled in this retrospective study. All subjects were evaluated by the Italian version of the Dimensional Apathy Scale and the Barratt Impulsiveness Scale-version 11, to assess, respectively, apathy and impulsiveness; they were divided into 2 groups (apathy and no apathy). All patients were administered also with questionnaires assessing depressive and anxious symptoms. Statistical analyses showed relevant results. In no-apathy group, education was a significant predictor on impulsiveness (attentional and motor) and apathy (executive and emotional); depression was a significant predictor on planning impulsivity and apathy. This study aimed to consider the importance of apathy and impulsivity in Parkinson disease. Although these are considered as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, these can also occur separately. Moreover, several variables could represent important predictors of apathy and impulsiveness, such as depression. Future investigations should deepen the role of other demographics and psychological variables.</p>
Parkinson disease validation algorithms
<p>The primary objective of this study was to validate two algorithms for the identification of persons with PD using clinical diagnosis as the reference standard on an Italian sample of people with PD. </p> <p>Two algorithms (index tests) applied to health administrative databases (hospital discharge, drug prescriptions, exemptions for medical costs) were validated against clinical diagnosis of PD by an expert neurologist (reference standard) in a cohort of consecutive outpatients.</p> <p>The two algorithms showed high accuracy for identifying patients with PD: one with greater sensitivity 94.2% (95% CI 88.4 – 97.6) and the other with greater specificity 98.1% (95% CI 97.7 – 98.5).</p>
Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease
<p>Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem control and PD brain tissue. We found a dramatic association of oligodendrocytes and oligodendrocyte precursor cells with PD-linked risk loci and reported several dysregulated genes and pathways, including regulation of tau-protein kinase activity, regulation of inclusion body assembly and protein processing involved in protein targeting to mitochondria.</p>
Intensive training programme improves handwriting in a community cohort of people with Parkinson's disease
<p><strong>Background</strong>: People with Parkinson’s disease (PwP) often report problems with their handwriting before they receive a formal diagnosis. Many PwP suffer from deteriorating handwriting throughout their illness, which has detrimental effects on many aspects of their quality of life. </p> <p><strong>Aims:</strong> To assess a 6-week online training programme aimed at improving handwriting of PwP. </p> <p><strong>Methods</strong>: Handwriting samples from a community-based cohort of PwP (n=48) were analysed using Systematic Detection of Writing Problems (SOS-PD) by two independent raters, before and after a 6-week remotely-monitored Physiotherapy-led training programme. Inter-rater variability on multiple measures of handwriting quality was analysed. The handwriting data was analysed using pre/post design in the same individuals. Multiple aspects of the handwriting samples were assessed, including writing fluency, transitions between letters, regularity in letter size, word spacing, and straightness of lines. </p> <p><strong>Results</strong>: Analysis of inter-rater reliability showed high agreement for total handwriting scores, letter size, as well as speed and legibility scores, whereas there were mixed levels of inter-rater reliability for other handwriting measures. Overall handwriting quality (p=0.001) and legibility (p=0.009) significantly improved, while letter size (p=0.012), fluency (p=0.001), regularity of letter size (p=0.009) and straightness of lines (p=0.036) were also enhanced. </p> <p><strong>Conclusions</strong>: The results of this study show that this 6-week intensive remotely-monitored Physiotherapy-led handwriting programme, improved handwriting in PwP. This is the first of its kind study using this tool remotely and it demonstrated that the SOS-PD is reliable for measuring handwriting in PwP.</p> <p><strong>Background</strong>: People with Parkinson’s disease (PwP) often report problems with their handwriting before they receive a formal diagnosis. Many PwP suffer from deteriorating handwriting throughout their illness, which has detrimental effects on many aspects of their quality of life. </p> <p><strong>Aims:</strong> To assess a 6-week online training programme aimed at improving handwriting of PwP. </p> <p><strong>Methods</strong>: Handwriting samples from a community-based cohort of PwP (n=48) were analysed using Systematic Detection of Writing Problems (SOS-PD) by two independent raters, before and after a 6-week remotely-monitored Physiotherapy-led training programme. Inter-rater variability on multiple measures of handwriting quality was analysed. The handwriting data was analysed using pre/post design in the same individuals. Multiple aspects of the handwriting samples were assessed, including writing fluency, transitions between letters, regularity in letter size, word spacing, and straightness of lines. </p> <p><strong>Results</strong>: Analysis of inter-rater reliability showed high agreement for total handwriting scores, letter size, as well as speed and legibility scores, whereas there were mixed levels of inter-rater reliability for other handwriting measures. Overall handwriting quality (p=0.001) and legibility (p=0.009) significantly improved, while letter size (p=0.012), fluency (p=0.001), regularity of letter size (p=0.009) and straightness of lines (p=0.036) were also enhanced. </p> <p><strong>Conclusions</strong>: The results of this study show that this 6-week intensive remotely-monitored Physiotherapy-led handwriting programme, improved handwriting in PwP. This is the first of its kind study using this tool remotely and it demonstrated that the SOS-PD is reliable for measuring handwriting in PwP.</p>
Generalizable electroencephalographic classification of Parkinson's disease using deep learning
<p>This is the data originally accessed from http://predict.cs.unm.edu/downloads.php </p> <p>Here, we provide the pre-processed data from our manuscript to allow for the easy replication of our experiments. </p> <p>Here is the repo associated with our paper: https://github.com/diamandis-lab/CNN_EEG_PD </p>
Omics data integration suggests a potential idiopathic Parkinson's disease signature
<p>Dataset linked to the manuscript under revision: <strong>Omics data integration suggests a potential idiopathic Parkinson's disease signature.</strong><i><strong> </strong>Complete manuscript information can be found here: https:/doi.org/</i>10.17881/v8jg-pw83</p>
Split-belt Treadmill Training for Freezing of Gait in Parkinson's Disease
ClinicalTrials.gov study NCT05511597. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of WB-EMS on Parkinson's Disease
ClinicalTrials.gov study NCT04878679. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Efficacy of Nano-PSO in Parkinson's Disease.
ClinicalTrials.gov study NCT05142085. IPD Sharing: NO. Countries: 1. Publications: 12.
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease
ClinicalTrials.gov study NCT00180037. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Selegiline for the Treatment of Excessive Daytime Sleepiness in Parkinson's Disease
ClinicalTrials.gov study NCT04870372. IPD Sharing: NO. Countries: 1. Publications: 2.
Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease
ClinicalTrials.gov study NCT01155492. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Riluzole to Treat Parkinson's Disease
ClinicalTrials.gov study NCT00013624. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Galantamine Executive Function in Parkinson's Disease
ClinicalTrials.gov study NCT00211588. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.