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993 results for “Traumatic brain injury”
Data from: Age-at-injury influences the glial response to traumatic brain injury in the cortex of male juvenile rats
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Expository and narrative discourse summary statistics and demographic information for adolescents with and without traumatic brain injury
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Sex, Race, and Risk of Dementia after Traumatic Brain Injury among Older Veterans
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Neurofilament light as a biomarker in traumatic brain injury
<p><strong>Objective:</strong> To determine whether serum neurofilament light (NfL) correlates with CSF NfL, traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) estimates of traumatic axonal injury (TAI).</p> <p><strong>Methods:</strong> Participants were prospectively enrolled in Sweden and the United States between 2011 and 2019. The Swedish cohort included 45 hockey players with acute concussion sampled at 6 days, 31 with repetitive concussion with persistent postconcussive symptoms (PCS) assessed with paired CSF and serum (median 1.3 years after concussion), 28 preseason controls, and 14 nonathletic controls. Our second cohort included 230 clinic-based participants (162 with TBI and 68 controls). Patients with TBI also underwent serum, functional outcome, and imaging assessments at 30 (n=30), 90 (n=48), and 180 (n=59) days and 1 (n=84), 2 (n=57), 3 (n= 46), 4 (n = 38), and 5 (n = 29) years after injury.</p> <p><strong>Results:</strong> In athletes with paired specimens, CSF NfL and serum NfL were correlated (r = 0.71, p < 0.0001). CSF and serum NfL distinguished players with PCS >1 year from PCS ≤1 year (area under the receiver operating characteristic curve [AUROC] 0.81 and 0.80). The AUROC for PCS >1 year vs preseason controls was 0.97. In the clinic-based cohort, NfL at enrollment distinguished patients with mild from those with moderate and severe TBI (p < 0.001 and p = 0.048). Serum NfL decreased over the course of 5 years (ß = −0.09 log pg/mL, p < 0.0001) but remained significantly elevated compared to controls. Serum NfL correlated with measures of functional outcome, MRI brain atrophy, and DTI estimates of TAI.</p> <p><strong>Conclusions:</strong> Serum NfL shows promise as a biomarker for acute and repetitive sports-related concussion and patients with subacute and chronic TBI.</p> <p><strong>Classification of Evidence: </strong>This study provides Class III evidence that increased concentrations of NfL distinguish patients with TBI from controls.</p>
Data from: Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in mice
The debilitating effects of repetitive concussive traumatic brain injury (rcTBI) have been increasingly recognized in both military and civilian populations. rcTBI may result in significant neurological, cognitive, and affective sequelae, and is often followed by physical and/or psychological post-injury stressors that may exacerbate the effects of the injury and prolong the recovery period for injured patients. However, the consequences of post-injury stressors and their subsequent effects on social and emotional behavior in the context of rcTBI have been relatively little studied in animal models. Here, we use a mouse model of rcTBI with two closed-skull blunt impacts 24 hours apart and social and emotional behavior testing to examine the consequences of a stressor (foot shock fear conditioning) following brain injury (rcTBI). rcTBI alone did not affect cued or contextual fear conditioning or extinction compared to uninjured sham animals. In the sucrose preference test, rcTBI animals had decreased preference for sucrose, an anhedonia-like behavior, regardless of whether they experienced foot shock stress or were non-shocked controls. However, rcTBI and post-injury foot shock stress had synergistic effects in tests of social recognition and depression-like behavior. In the social recognition test, animals with both injury and shock were more impaired than either non-shocked injured mice or shocked but uninjured mice. In the tail suspension test, injured mice had increased depression-like behavior compared with uninjured mice, and shock stress worsened the depression-like behavior only in the injured mice with no effect in the uninjured mice. These results provide a model of subtle emotional behavioral deficits after combined concussive brain injury and stress, and may provide a platform for testing treatment and prevention strategies for social behavior deficits and mood disorders that are tailored to patients with traumatic brain injury.
Data from: Characteristics of patients included and enrolled in studies on the prognostic value of serum biomarkers for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review
Objective: Mild traumatic brain injury (mTBI) has been insufficiently researched and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalizability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict post-concussion symptoms following a mTBI. Data sources: Searches of MEDLINE, EMBASE, CENTRAL, CINAHL, Web of Science, PsycBITE, and PsycINFO up to October 2016. Data selection and extraction: Two reviewers independently screened for potentially eligible studies, extracted data and assessed the overall quality of evidence by outcome using the Grading of Recommendations Assessment, Development and Evaluation approach. Results: A total of 23,298 citations were obtained from which 166 manuscripts were reviewed. Thirty-six cohort studies (2,812 patients) having enrolled between 7 and 311 patients (median 89) fulfilled our inclusion criteria. Most studies excluded patients based on advanced age (n=10 (28%)), neurologic disorders (n=20 (56%)), psychiatric disorders (n=17 (47%)), substance abuse disorders (n=13 (36%)) or previous TBI (n=10 (28%)). Twenty-one studies (58%) used at least two of these exclusion criteria. The pooled mean age of included patients was 39.3 (SD 4.6) years old (34 studies). The criteria used to define a mTBI were inconsistent. The most frequently reported outcome was post-concussion syndrome (PCS) using the Rivermead Post-Concussion Symptoms Questionnaire (n=18 (50%)) with follow-ups ranging from 7 days to 5 years after the mTBI. Conclusions: Most studies have recruited samples that are not representative and generalizable to the mTBI population. These exclusion criteria limit the potential use and translation of promising serum protein biomarkers to predict post-concussion symptoms.
Figure 4 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 4 Immunohistochemical staining of Caspase-3 400× microscope magnification. Picture of caspase 3 expression in the cerebral cortex area shows a picture of caspase 3 expression in the cytoplasm of neuron cells (yellow arrow). A. The normal control group showed a score of 0; B. The negative control group shows a score of 4; C. Group A shows a score of 3; D. Group B shows a score of 2; E. Group C shows a score of 1.
Figure 5 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 5 Histopathological picture of brain tissue damage with HE staining, 400× microscope magnification. Description: Histopathological picture of the cerebral cortex area shows degeneration of neuron cells (yellow arrows). A. The normal control group shows a score of 0; B. The negative control group shows a score of 2; C. Group A shows a score of 2; D. Group B shows a score of 1; E. Group C shows a score of 1.
Figure 2 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 2 TLR4 immunohistochemical staining with a microscope magnification of 400×. Description: TLR4 expression in the cerebral cortex area shows TLR4 expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 20%; C. Group A expressed 15%; D. Group B expressed 15%; E. Group C expressed 10%.
Figure 3 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 3 TNF-α immunohistochemical staining with a microscope magnification of 400×. TNF-α expression in the cerebral cortex area shows TNF-α expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 15%; C. Group A was depressed 10%; D. Group B expressed 10%; E. Group C expressed 5%.
"Quacking for Noggin": Farm Animal–Assisted Therapy for Traumatic Brain Injury Survivors
<p>The aim of this study was to examine the effects of animal-assisted therapies with farm animals (AATF), in this case domesticated ducks, on depression, anxiety, and self-efficacy in patients with traumatic brain injury (TBI). Furthermore, the following hypothesis was tested: Engaging in AATF with domesticated ducks will be associated with decreased depression, decreased anxiety, and increased self-efficacy. The study examined the effects of AATF on anxiety, depression, and self-efficacy among nine patients with TBI. A time series quasi-experimental design was utilized. Participants completed the Hospital Anxiety and Depression Survey (HADS) and General Self-Efficacy (GSE) questionnaires at baseline, followed by the AAFT intervention. The AAFT intervention consisted of two one-hour sessions interacting with ducks every week for 12 weeks. Participants repeated baseline measures immediately following the intervention, and again four weeks post intervention to evaluate the residual effects of the intervention. A general linear model was employed to examine changes in anxiety, depression, and selfefficacy. Participants’ anxiety scores decreased significantly from baseline to post intervention measure (p = .009); however, there were no statistically significant differences between anxiety levels immediately post intervention and four weeks later. There were no statistically significant differences in depression or self-efficacy levels at pre-, post-, and retest. Our study hypothesis was partially supported in that statistically significant decreases in anxiety were observed from baseline to immediate posttest. Mastery of skills, vicarious experiences, and verbal persuasion may be the factors that contributed to the beneficial outcomes of the interactions between persons with TBI and domesticated ducks</p>
Dataset related to article "Mapping Brain Small Metabolite Changes After Traumatic Brain Injury using AP-MALDI MSI"
<p>Raw data for figures 2,3 and 4 regarding mass spectrometry imaging dataset</p>
Dataset related to article "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"
<p>Dataset related to manuscript "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"</p> <p>Each excel file contains raw data relative to data shown in Figures</p>
Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury
ClinicalTrials.gov study NCT02629588. IPD Sharing: NO. Countries: 0. Publications: 21.
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
ClinicalTrials.gov study NCT06644131. IPD Sharing: YES. Countries: 1. Publications: 0.
Role of Electrocardiogram Abnormalities in Prediction of Mortality in Patients with Isolated Traumatic Brain Injury
ClinicalTrials.gov study NCT06701279. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
ClinicalTrials.gov study NCT01021137. IPD Sharing: NO. Countries: 1. Publications: 0.
Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
ClinicalTrials.gov study NCT00973674. IPD Sharing: NO. Countries: 1. Publications: 0.
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.
ClinicalTrials.gov study NCT00766038. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI)
ClinicalTrials.gov study NCT02367521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.