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809
datasets available to search
ShareScore release 0.9.0
Dataset results
809 results for “complement”
A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors
ClinicalTrials.gov study NCT04434092. IPD Sharing: YES. Countries: 23. Publications: 2.
Complement Inhibition With Eculizumab for the Treatment of Non-Exudative Macular Degeneration (AMD)
ClinicalTrials.gov study NCT00935883. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Complement and Cardiovascular Risk in Adolescents
ClinicalTrials.gov study NCT02821104. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of ALXN1210 in Complement Inhibitor Treatment-Naïve Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
ClinicalTrials.gov study NCT02949128. IPD Sharing: Not stated. Countries: 14. Publications: 5.
ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
ClinicalTrials.gov study NCT02946463. IPD Sharing: Not stated. Countries: 26. Publications: 6.
Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation
ClinicalTrials.gov study NCT01327573. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhib
ClinicalTrials.gov study NCT04654468. IPD Sharing: YES. Countries: 1. Publications: 2.
Study to Evaluate the Safety, Tolerability of BCX9930 in Participants With Either Complement 3 Glomerulopathy (C3G), Immunoglobulin A Nephropathy (IgAN), or Primary Membranous Nephropathy (PMN)
ClinicalTrials.gov study NCT05162066. IPD Sharing: NO. Countries: 4. Publications: 1.
Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders
ClinicalTrials.gov study NCT02502903. IPD Sharing: YES. Countries: 1. Publications: 5.
A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)
ClinicalTrials.gov study NCT04435366. IPD Sharing: NO. Countries: 20. Publications: 3.
Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration
ClinicalTrials.gov study NCT01115231. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Plant-derived environmental DNA complements diversity estimates from traditional arthropod monitoring methods but outperforms them detecting plant-arthropod interactions
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Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
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FT TFL1 bimolecular luciferase complementation assays
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Data from: Energetic fitness: field metabolic rates assessed via 3D accelerometry complement conventional fitness metrics
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Leech-derived iDNA complements traditional surveying methods, enhancing species detections for rapid biodiversity sampling in the tropics
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Dataset: DNA barcodes and microsatellites: how they complement for species identification in the complex genus Tamarix (Tamaricaceae)
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Data from: Citizen science can complement professional invasive plant surveys and improve estimates of suitable habitat
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Data from: Delivered complementation in planta (DCIP) enables measurement of peptide-mediated protein delivery efficiency in plants
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REV-ERBalpha mediates complement expression and circadian regulation of microglial synaptic phagocytosis
<p>The circadian clock has been shown to regulate various aspects of brain health including microglial and astrocyte activation. Here we report that deletion of the master clock protein BMAL1 induces robust increases in the expression of complement genes such as <i>C3, C4b </i>and <i>C1q</i> in the hippocampus. Loss of downstream REV-ERBa-mediated transcriptional repression led to increases in <i>C4b </i>in neurons and astrocytes as well as C3 protein in microglia and astrocytes. REV-ERBa deletion induced complement <i>C3/C4b </i>gene expression and increased microglial phagocytosis of synapses in the CA3 region of the hippocampus. Finally, we observed diurnal variation in the degree of microglial synaptic phagocytosis in wild type mice which was abrogated by REV-ERBα deletion. This work uncovers the BMAL1-REV-ERBa axis as a regulator of complement expression and synaptic phagocytosis in the brain, thereby illuminating a novel mechanism of synaptic regulation by the circadian clock.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.