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361
datasets available to search
ShareScore release 0.9.0
Dataset results
361 results for “regurgitation”
Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation
ClinicalTrials.gov study NCT04595448. IPD Sharing: NO. Countries: 1. Publications: 0.
Ambulant Monitoring to Detect Hemodynamic and Electrical Impact of Severe Tricuspid Valve Regurgitation
ClinicalTrials.gov study NCT07043465. IPD Sharing: NO. Countries: 1. Publications: 0.
A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation
ClinicalTrials.gov study NCT04147884. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
SATURN Transcatheter Mitral Valve Replacement for Functional Mitral Regurgitation
ClinicalTrials.gov study NCT04464876. IPD Sharing: NO. Countries: 3. Publications: 0.
Dataset related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation"
<p>This record contains raw data related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients—candidates for mitral valve repair (MVRep)—showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 controls. Oxidized (GSSG) and reduced (GSH) forms of glutathione, and L-arginine metabolic pathway were analyzed using liquid chromatography-tandem mass spectrometry methods while osteoprotegerin (OPG) through the ELISA kit and circulating endothelial microparticles (EMP) by flow cytometry. Six-month post surgery, in MVP patients, the GSSG/GSH ratio decreased while symmetric and asymmetric dimethylarginines levels remained comparable to the baseline. Conversely, OPG levels significantly increased when compared to their baseline. Finally, pre-MVRep EMP levels were significantly higher in patients than in controls and did not change post surgery. Overall, these results highlight that MVRep completely restores the increased oxidative stress levels, as evidenced in MVP patients. Conversely, no amelioration of endothelial dysfunction was evidenced after surgery. Thus, therapies aimed to restore a proper endothelial function before and after surgical repair could benefit MVP patients.</p>
Partial dataset related to the article "Structural and functional abnormalities of left-sided cardiac chambers in Barlow's disease without significant mitral regurgitation"
<p>This record contains raw data related to the article "Structural and functional abnormalities of left-sided cardiac chambers in Barlow’s disease without significant mitral regurgitation".</p> <p><strong>Aims </strong>This study aims to explore the presence of left ventricular (LV) and left atrial (LA) morphological and functional abnormalities in patients with Barlow’s disease (BD) without significant mitral regurgitation (MR) and to investigate whether these abnormalities may predict MR progression.<span> </span></p> <p><strong>Methods and results </strong>Consecutive patients with BD were retrospectively identified from two tertiary centres; those with MR graded from trivial to mild-to-moderate were selected and matched with healthy controls in a 1:1 ratio. Conventional and speckle-tracking echocardiographic data were collected. The development of moderate-to-severe or greater MR was evaluated on follow-up echocardiograms. Patients with BD (<em>n </em>= 231) showed increased LV dimensions and indexed LV mass (LVMi) in comparison with controls (<em>P </em>< 0.001); LV remodelling worsened with higher MR severity and was accompanied by an increased prevalence of eccentric LV hypertrophy (eLVH). Moreover, BD patients had larger LA volumes and more impaired LA reservoir strain vs. controls (<em>P </em>< 0.001), while LV strain was similar between the two groups. Multivariable linear regression analyses in the overall population identified BD and MR grade as independent predictors of remodelling markers (LV dimensions, LVMi, and LA volume) and BD as independent correlate of LA strain. MR progression was observed in 51 BD subjects (out of 170 patients with available follow-up). On Cox regression analysis, age, eLVH, mild-to-moderate MR, and mitral annular disjunction (MAD) emerged as independent predictors of MR progression.<span> </span></p> <p><strong>Conclusion </strong>BD patients without significant MR show early LV and LA remodelling, together with reduced LA strain. MR progression was associated with eccentric LV remodelling, MAD, and MR severity.<span> </span></p>
Haemodynamic assessment and the outcomes of aortic valvuloplasty for aortic regurgitation in patients with bicuspid aortic valve
Open the record for dataset details and reuse information.
Study on the Tolerance and Efficacy of a New Anti Regurgitation Formula
ClinicalTrials.gov study NCT02425423. IPD Sharing: Not stated. Countries: 2. Publications: 0.
SWAN: Study on the Tolerance and Efficacy of a New Anti-regurgitation Formula (PC-2016-01)
ClinicalTrials.gov study NCT02710955. IPD Sharing: Not stated. Countries: 1. Publications: 0.
EXPLORE FMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation
ClinicalTrials.gov study NCT04679714. IPD Sharing: NO. Countries: 0. Publications: 0.
Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF
ClinicalTrials.gov study NCT02985268. IPD Sharing: NO. Countries: 0. Publications: 0.
European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation
ClinicalTrials.gov study NCT05425628. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Evaluation of the Impact of Tricuspid Regurgitation on Patients Lives. Exploration of Experience and Impact on a Daily Basis.
ClinicalTrials.gov study NCT05532956. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Coronary Heart Disease Complicated With Ischemic Mitral Regurgitation in China
ClinicalTrials.gov study NCT07230756. IPD Sharing: NO. Countries: 0. Publications: 0.
HighLife Clarity Treatment of Severe Mitral Regurgitation
ClinicalTrials.gov study NCT06683729. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR
ClinicalTrials.gov study NCT02701972. IPD Sharing: NO. Countries: 0. Publications: 0.
Surgical Correction of Moderate Ischemic Mitral Regurgitation
ClinicalTrials.gov study NCT00394797. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imagin
ClinicalTrials.gov study NCT04795856. IPD Sharing: NO. Countries: 0. Publications: 0.
Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation
ClinicalTrials.gov study NCT04098328. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Haemodynamics of Mitral Regurgitation Reduction
ClinicalTrials.gov study NCT05403840. IPD Sharing: NO. Countries: 0. Publications: 0.
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OpenNeuro
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