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334
datasets available to search
ShareScore release 0.9.0
Dataset results
334 results for “targeted cancer therapy”
Autophagy Inhibition via Targeting of PIKfyve Potentiates Immune Checkpoint Blockade in Prostate Cancer Therapy
GEO Series GSE174644. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing.
Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
GEO Series GSE302284. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Rise in KRT17 sensitizes platinum-resistant ovarian cancer organoids to targeted therapies
GEO Series GSE288422. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer [RNA-Seq]
GEO Series GSE70046. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Immunogenic Senescence Sensitizes Lung Cancer to LUNX-Targeting Therapy [A549]
GEO Series GSE185207. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
LncRNA HAND2-AS1 controls liver cancer stem cell functions and serves as a potential therapy target (RNA microarray)
GEO Series GSE126121. Homo sapiens. 8 samples. Type: Expression profiling by array.
Telomerase-mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Multi-drug Chemotherapy Resistance
GEO Series GSE109821. Homo sapiens. 54 samples. Type: Expression profiling by high throughput sequencing.
LncRNA HAND2-AS1 controls liver cancer stem cell functions and serves as a potential therapy target (ChiRP-Seq)
GEO Series GSE126122. Homo sapiens. 6 samples. Type: Other.
Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer [ChIP-Seq]
GEO Series GSE70045. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Patient-derived primary xenografts in the preclinical development of novel targeted therapies for bladder cancer
GEO Series GSE67312. Homo sapiens; Mus musculus. 10 samples. Type: Expression profiling by array.
Final efficacy and biomarker analysis of the sorafenib arm of the BATTLE (Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination) trial
GEO Series GSE31428. Homo sapiens. 37 samples. Type: Expression profiling by array.
Immunogenic Senescence Sensitizes Lung Cancer to LUNX-Targeting Therapy
GEO Series GSE185209. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Adaptive Volumetric-Modulated Arc Radiation Therapy for Head and Neck Cancer: Evaluation of Benefit on Target Coverage and Sparing of Organs at Risk"
<p>This record contains raw data related to article "Adaptive Volumetric-Modulated Arc Radiation Therapy for Head and Neck Cancer: Evaluation of Benefit on Target Coverage and Sparing of Organs at Risk"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>Radiotherapy is essential in the management of head-neck cancer. During the course of radiotherapy, patients may develop significant anatomical changes. Re-planning with adaptive radiotherapy may ensure adequate dose coverage and sparing of organs at risk. We investigated the consequences of adaptive radiotherapy on head-neck cancer patients treated with volumetric-modulated arc radiation therapy compared to simulated non-adaptive plans: Materials and methods: We included in this retrospective dosimetric analysis 56 patients treated with adaptive radiotherapy. The primary aim of the study was to analyze the dosimetric differences with and without an adaptive approach for targets and organs at risk, particularly the spinal cord, parotid glands, oral cavity and larynx. The original plan (OPLAN) was compared to the adaptive plan (APLAN) and to a simulated non-adaptive dosimetric plan (DPLAN).</p><p><strong>Results: </strong>The non-adaptive DPLAN, when compared to OPLAN, showed an increased dose to all organs at risk. Spinal cord D2 increased from 27.91 (21.06-31.76) Gy to 31.39 (27.66-38.79) Gy (<i>p</i> = 0.00). V15, V30 and V45 of the DPLAN vs. the OPLAN increased by 20.6% (<i>p</i> = 0.00), 14.78% (<i>p</i> = 0.00) and 15.55% (<i>p</i> = 0.00) for right parotid; and 16.25% (<i>p</i> = 0.00), 18.7% (<i>p</i> = 0.00) and 20.19% (<i>p</i> = 0.00) for left parotid. A difference of 36.95% was observed in the oral cavity V40 (<i>p</i> = 0.00). Dose coverage was significantly reduced for both CTV (97.90% vs. 99.96%; <i>p</i> = 0.00) and PTV (94.70% vs. 98.72%; <i>p</i> = 0.00). The APLAN compared to the OPLAN had similar values for all organs at risk.</p><p><strong>Conclusions: </strong>The adaptive strategy with re-planning is able to avoid an increase in dose to organs at risk and better target coverage in head-neck cancer patients, with potential benefits in terms of side effects and disease control.</p>
New Strategy for the Development of Targeted Drug Delivery Systems in Cancer Therapy
<p>Rare dataset of the experiments performed during the investigation of our newly developed SREKA pentapeptide, and its use for liposome preparation.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.