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3,476 results for “Parkinson disease”
MicroRNA (miRNA) expression profiling of blood leukocytes of Parkinson's disease (PD) patients pre- and post-deep brain stimulation treatment and of healthy control volunteers
GEO Series GSE38385. synthetic construct; Homo sapiens. 13 samples. Type: Non-coding RNA profiling by array.
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [RNA-Seq]
GEO Series GSE271115. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
A novel approach for investigating Parkinson's Disease personality and its association with clinical and psychological aspects.
<p><strong>Objective:</strong> A complex relationship between neuropsychiatric symptoms, personality traits and neurochemical changes in patients with Parkinson’s disease (PD) has been highlighted in the past several decades. In particular, a specific Parkinson personality with obsessive traits has been described. However, despite the great amount of anecdotal evidence, this aspect, together with its neurobiological, psychological and clinical correlates, are still not clearly defined. Therefore, we performed a case-control study in order to investigate the presence and rate of obsessive personality traits in PD patients within the theoretical framework of cognitive-constructivist model. Moreover, the relationship between PD personality and clinical, psychological and quality of life (QoL) aspects in PD were investigated.</p> <p><strong>Methods:</strong> Fifty-one non-demented patients with probable or possible PD (not demented) were recruited at the inpatient-outpatient San Luca Hospital, IRCCS Istituto Auxologico Italiano. Control group was composed by forty-eight age- and education-matched healthy volunteers. Patients underwent a neurological investigation including Unified PD Rating Scale (UPDRS), Modified Hoehn and Yahr and Schwab and England staging scales. The following psychological questionnaires were administered to the overall sample: Personal Meaning Questionnaire (PMQ), State-Trait Anxiety Inventory-Form Y (STAI-Y), Beck Depression Inventory (BDI), Symptom Check List-90 (SCL-90), Short-Form Health Survey-36 (SF-36).</p> <p><strong>Results:</strong> No significant differences in personality styles were observed in PD patients and controls, with a prevalence of phobic personal meaning organization (PMO) in both groups. However, PD patients showed more anxiety, depression and obsessive-compulsive (OC) symptoms than controls at the psychological questionnaires, as well as poorer QoL levels. The intensity of personality traits, and in particular for the obsessive personality style, were negatively associated with QoL and positively with disease severity. No significant relationships were observed between personality and other clinical aspects, such as side of onset and disease duration.</p> <p><strong>Conclusion:</strong> Parkinson’s disease patients did not show a different personality profile according to the cognitive-constructivist model with respect to controls. However, in this population, a general enhancement in the tendency to codify experience by means of specific cognitive and emotional patterns was associated to disease progression and to a poorer QoL.</p>
Defective Tool Embodiment in Body Representation of Individuals Affected by Parkinson's Disease
<p>Data set associated with the article "Defective Tool Embodiment in Body Representation of Individuals Affected by Parkinson's Disease"</p>
Performance at the clock drawing test of individuals affected by Parkinson's disease and healthy subjects
<p>Data set associated with the article "Performance at the clock drawing test of individuals affected by Parkinson's disease and healthy subjects"</p>
Mental representation of the body in action in Parkinson's disease
<p>Data set associated with the article "Mental representation of the body in action in Parkinson's disease"</p>
Sleep microstructure in Parkinson's disease: cycling alternating pattern (CAP) as a sensitive marker of early NREM sleep instability.
<p>Data set related to the journal article:</p> <p>Priano L, Bigoni M, Albani G, Sellitti L, Giacomotti E, Picconi R, Cremascoli R, Zibetti M, Lopiano L, Mauro A. Sleep microstructure in Parkinson's disease: cycling alternating pattern (CAP) as a sensitive marker of early NREM sleep instability. Sleep Med. 2019 Sep;61:57-62. doi: 10.1016/j.sleep.2019.03.025. Epub 2019 Apr 20. PMID: 31307885.</p>
Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand
<p>Dataset associated with the article:</p> <p>Scarpina F, Bruno V, Rabuffetti M, Priano L, Tagini S, Gindri P, Mauro A, Garbarini F. Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand. <em>Neuropsychologia.</em> 2020 Dec 10;151:107718. doi: 10.1016/j.neuropsychologia.2020.107718.</p> <p> </p>
DATASET RELATED TO ARTICLE "The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells"
<p>RAW DATA RELATED TO ARTICLE AT TITLE</p>
Reliable change indices for the Italian version of the Montreal Cognitive Assessment (MoCA) in non-demented Parkinson's disease patients
<p>Dataset associated with the paper "Reliable change indices for the Italian version of the Montreal Cognitive Assessment (MoCA) in non-demented Parkinson's disease patients". These datasets cannot be made publicly available on ethical legal grounds but can be made available upon reasonable request of interested researchers to the Corresponding Author(s), who will forward a request for a data transfer agreement to the relevant Ethical Committee(s). Please, write to Dr. Barbara Poletti (b.poletti@auxologico.it)</p>
Rest and Postural Tremor in Parkinson's Disease
<p>This protocol was designed to measure rest tremor and postural tremor for Parkinson's disease studies. </p> <p> </p> <p>The project is a joint collaboration between the Centre for Innovation and Technology Assessment in Health (NIATS) at Federal University of Uberlndia Uberlndia, the Signal Analysis Research (SAR) group at Ryerson University, and the Associao Parkinson do Tringulo.</p> <p><br> This work is funded by the National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel (CAPES Program CAPES/DFATD-88887.159028/2017-00) and the Foundation for Research Support of the State of Minas Gerais (FAPEMIG-APQ-00942-17), Ryerson University, Canadian Natural Sciences and Engineering Research Council (NSERC), and Canadian Bureau for International Education Canada. A. O. Andrade is a Fellow of CNPq, Brazil (304818/2018).</p>
Datase related to article "NOVEL DEEP INTRONIC MUTATION IN PLA2G6 CAUSING EARLY-ONSET PARKINSON'S DISEASE WITH BRAIN IRON ACCUMULATION THROUGH PSEUDO-EXON ACTIVATION"
<p>The database contains the sequencing data included in the article at title</p>
Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson's and Huntington's disease
<p>Dataset associated with the paper: "Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease".</p>
Dataset_A Psychometric Tool for Evaluating Executive Functions in Parkinson's Disease
<p>Dataset of raw data used in the paper "A Psychometric Tool for Evaluating Executive Functions in Parkinson’s Disease"</p>
Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson's disease patients
<p>Dataset associated with the paper: "Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients"</p>
Ecological Validity of the Montreal Cognitive Assessment in Non-Demented Parkinson's Disease Patients
<p>Dataset associated with the paper: "Ecological Validity of the Montreal Cognitive Assessment in Non-Demented Parkinson’s Disease Patients".</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.