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5,856 results for “B cells”
Healthy and B-cell precursor Acute Lymphoblastic Leukemia (ALL) cells analyzed via CyTOF
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A B cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation
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Data from: Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells
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Quantification of hair cell number, ribeye b and nuclei in the zebrafish inner ear endorgans
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B cell receptor parent-child pairs for studying somatic hypermutation
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An amphipol-stabilized multi-pass transmembrane protein as an immunogen to generate mouse memory B cells against native VMAT2
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Data from: Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells
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Profiling of linear B-cell epitopes against human coronaviruses in pooled sera sampled early in the COVID-19 pandemic
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Data from: Targeted checkpoint control of B cells undergoing positive selection in germinal centers by follicular regulatory T cells
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Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
<p>This repository contains necessary files for reproducing the analysis in Rabilloud, Potier et al. (2020). The instructions for reproducing the analysis are given in github (https://github.com/Delphine-Potier/B-ALL-CAR-T) and extra files are available in GEO/SRA (GSE153697 ; SRP269742).</p>
Data from: Human circulating antibody-producing B cell as a predictive measure of mucosal immunity to poliovirus
Background: The "gold standard" for assessing mucosal immunity after vaccination with poliovirus vaccines consists in measuring virus excretion in stool after challenge with oral poliovirus vaccine (OPV). This testing is time and resource intensive, and development of alternative methods is a priority for accelerating polio eradication. We therefore evaluated circulating antibody-secreting cells (ASCs) as a potential means to evaluate mucosal immunity to poliovirus vaccine. Methods: 199 subjects, aged 10 years, and previously immunized repeatedly with OPV, were selected. Subjects were assigned to receive either a booster dose of inactivated poliovirus vaccine (IPV), bivalent OPV (bOPV), or no vaccine. Using a micro-modified whole blood-based ELISPOT assay designed for field setting, circulating poliovirus type-specific IgA- and IgG-ASCs, including gut homing ?4?7+ ASCs, were enumerated on days 0 and 7 after booster immunization. In addition, serum samples collected on days 0, 28 and 56 were tested for neutralizing antibody titers against poliovirus types 1, 2, and 3. Stool specimens were collected on day 28 (day of bOPV challenge), and on days 31, 35 and 42 and processed for poliovirus isolation. Results: An IPV dose elicited blood IgA- and IgG-ASC responses in 84.8 to 94.9% of subjects, respectively. In comparison, a bOPV dose evoked corresponding blood ASC responses in 20.0 to 48.6% of subjects. A significant association was found between IgA- and IgG-ASC responses and serum neutralizing antibody titers for poliovirus type 1, 2, 3 (p<0.001). In the IPV group, ?4?7+ ASCs accounted for a substantial proportion of IgA-ASCs and the proportion of subjects with a positive ?4?7+ IgA-ASC response to poliovirus types 1, 2 and 3 was 62.7%, 89.8% and 45.8%, respectively. A significant association was observed between virus excretion and ?4?7+ IgA- and/or IgG-ASC responses to poliovirus type 3 among immunized children; however, only a weak association was found for type 1 poliovirus. Discussion: Our results suggest that virus-specific blood ASCs, especially for type 3 poliovirus, can serve as surrogate of mucosal immunity after vaccination. Further studies are needed to evaluate the duration of such memory responses and to assess the programmatic utility of this whole blood-based mucosal ASC testing for the polio eradication program.
Data from: A public database of memory and naive B-cell receptor sequences
The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics.
Simulated B-cells Rep-Seq datasets (called SIMULATED) from "Reconstructing antibody repertoires from error-prone immunosequencing datasets" paper
<p>Simulated test datasets used for benchmarking of immunorepertoire construction tools</p>
Gluten-free diet exposure prohibits pathobiont expansion and gluten sensitive enteropathy in B cell deficient mice
<p>In humans, celiac disease (CeD) is a T-cell-driven gluten-sensitive enteropathy (GSE) localized to the small bowel (duodenum). The presence of antibodies specific for gluten- and self-antigens are commonly used diagnostic biomarkers of CeD and are considered to play a role in GSE pathogenesis. Previously, we have described an apparent T-cell-mediated GSE in CD19<sup>-/-</sup> mice, which develop weak and abnormal B cell responses. Here, we expand on this observation and use a mouse model of complete B cell deficiency (J<sub>H</sub><sup>-/-</sup> mice), to show that absence of a humoral immune response also promotes development of a GSE. Furthermore, 16S analysis of microbial communities in the small intestine (SI) demonstrates that a gluten-free diet (GFD) suppresses the expansion of anaerobic bacteria in the SI and colonization of the SI by a specific pathobiont. Finally, we also observe that SI enteropathy in mice fed a gluten-rich diet (GRD) is positively correlated with the abundance of several microbial peptidase genes, which supports that bacterial metabolism of gluten may be an important driver of GSE in our model. Collectively, results from our experiments indicate that J<sub>H</sub><sup>-/-</sup> mice will be a useful resource to investigators seeking to empirically delineate the contribution of humoral immunity on GSE pathogenesis, and support the hypothesis that humoral immunity promotes tolerance to gluten.</p>
FIGURE 2. Anthoceros subtilis. A. Whole plants. B. Antheridia with tiered jacket cell arrangement. C in Anthoceros subtilis and A. telaganus (Anthocerotaceae): two new records for America from the hornwort flora of Mexico
FIGURE 2. Anthoceros subtilis. A. Whole plants. B. Antheridia with tiered jacket cell arrangement. C. Thallus transverse section with schizogenous (Sc) cavities and Nostoc colonies (Nos). D. Dorsal surface cells with chloroplasts displaying central pyrenoids. E. Sporophyte transverse section with epidermal layer (ep), assimilative layer (as) and spores (sp). F. Epidermal layer of capsule with stomata. G. Spore ornamentation on distal surface (i), proximal surface (ii) and pseudoelaters.
FIGURE 4. Anthoceros telaganus. A. Whole plant. B. Thallus transverse section with schizogenous cavities. C. Antheridia with tiered jacket cell arrangement. D. Involucre transverse section with schizogenous cavities. E in Anthoceros subtilis and A. telaganus (Anthocerotaceae): two new records for America from the hornwort flora of Mexico
FIGURE 4. Anthoceros telaganus. A. Whole plant. B. Thallus transverse section with schizogenous cavities. C. Antheridia with tiered jacket cell arrangement. D. Involucre transverse section with schizogenous cavities. E. Sporophyte transverse section with epidermal layer (ep), assimilative layer (as), spore (sp) and columella (co). F. Epidermal layer of capsule with stomata. G. Spore ornamentation on distal surface (i), proximal surface (ii) and pseudoelaters.
FIGURE. Microscopic structures of Rhodocollybia tablensis a, b, e, f (PAN238), c, d (KaiR343) a. Basidia. b. Basidiospores. c. Cheilocystidia. d. Pleurocystidia. e. Stipitipellis with caulocystidia. f. Pileipellis with terminal cells. Bars a, b and c = 10 µm, d, e and f = 20 µm. Drawings by H. Lotz-Winter. in New and interesting species of Agaricomycetes from Panama
FIGURE. Microscopic structures of Rhodocollybia tablensis a, b, e, f (PAN238), c, d (KaiR343) a. Basidia. b. Basidiospores. c. Cheilocystidia. d. Pleurocystidia. e. Stipitipellis with caulocystidia. f. Pileipellis with terminal cells. Bars a, b and c = 10 µm, d, e and f = 20 µm. Drawings by H. Lotz-Winter.
FIGURE. Coprolites preserved in an early Permian fern mesophyll. A, Gross morphology of a fragmentary fern frond, specimen PB23532. B, Basal part of a penultimate pinna showing sphenopteroid vegetative pinnules. C, Polished surface showing two sporangia with typical annulus structures (white arrowheads). D, SEM image showing an in situ trilete spore. E, The fertile pinnule which contains numerous coprolites along a transverse wound area. F, Enlargement showing coprolites filled with brown to black contents. G, SEM image of the same part in E. H, SEM image showing locally preserved epidermal cells and nearby coprolites. in Discovery of coprolites in an Early Permian fern mesophyll
FIGURE. Coprolites preserved in an early Permian fern mesophyll. A, Gross morphology of a fragmentary fern frond, specimen PB23532. B, Basal part of a penultimate pinna showing sphenopteroid vegetative pinnules. C, Polished surface showing two sporangia with typical annulus structures (white arrowheads). D, SEM image showing an in situ trilete spore. E, The fertile pinnule which contains numerous coprolites along a transverse wound area. F, Enlargement showing coprolites filled with brown to black contents. G, SEM image of the same part in E. H, SEM image showing locally preserved epidermal cells and nearby coprolites.
Dataset for Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
<p>This data set provides:</p> <p>a) Details about plasmids used in this study. It is a pdf file, describing expressed sequences and other features of plasmids listed in Supplementary Table 2.</p> <p>b) An Excel file with data used to make graphs of the publication</p>
FIGURE 3. Asteridiella elaeocarpicola var. gadgilii. a. Appressorium. b. Phialide. c. Perithecial wall cells. d in A new species and a new variety of Meliolaceae fungi from India
FIGURE 3. Asteridiella elaeocarpicola var. gadgilii. a. Appressorium. b. Phialide. c. Perithecial wall cells. d. Ascospores. Illustrator: Aliyarukunju Sabeena.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.