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Flight Data For Tail 684

The following zip files contain individual flight recorded data in Matlab file format. There are 186 parameters each with a data structure that contains the following: <pre> -sensor recordings -sampling rate -units -parameter description -parameter ID </pre>

Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data

RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver tissues from RR-1 mice (female C57Bl6/J 16wk old at time of launch) including eight from the Flight group and eight from the Ground Control group. From each group two liver samples were collected and frozen immediately after euthanasia (Flight mice dissected on-orbit after total 37 days after launch Samples FLT-M21 M22 and corresponding Ground Control samples GC-M31,M32). An additional six samples from each group were collected from frozen carcasses dissected post-flight (Samples FLT-M25,M26,M27,M28,M29,M30 and corresponding Ground Control samples GC-M35,M36,M37,M38,M39,M40). RNA-Seq whole genome and RNA BS-Seq (bisulfite sequencing) and proteomic expression profiling were performed.

Rodent Research-1 (RR1) NASA Validation Flight: Mouse kidney transcriptomic proteomic and epigenomic data

NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS) it is imperative to use crew time efficiently while maximizing high-quality science return. NASA s GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics systems biology-based approach and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA DNA and protein extracted from archived RR-1 tissue samples for epigenomic transcriptomic and proteomic assays. During the first RR spaceflight experiment a variety of tissue types were harvested from subjects snap-frozen or RNAlater-preserved and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands quadriceps gastrocnemius tibialis anterior extensor digitorum longus soleus eye and kidney. We report here protocols for and results of these tissue extractions and thus the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.

Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic, proteomic, epigenomic and histology data

Translating fundamental biological discoveries from NASA Space Biology program into health risk from space flights has been an ongoing challenge. We propose to use NASA GeneLab database to gain new knowledge on potential systemic responses to space. Unbiased systems biology analysis of transcriptomic data from seven different rodent datasets reveals for the first time the existence of potential 'master regulators' coordinating a systemic response to microgravity and/or space radiation with TGF-β1 being the most common regulator. We hypothesized the space environment leads to the release of biomolecules circulating inside the blood stream. Through datamining we identified 13 candidate microRNAs (miRNA) which are common in all studies and directly interact with TGF-β1 that can be potential circulating factors impacting space biology. This study exemplifies the utility of the GeneLab data repository to aid in the process of performing novel hypothesis-based research.

Rodent Research-1 (RR1) NASA Validation Flight: Mouse eye transcriptomic and epigenomic data

NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.

MMS 2 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Energy by Time of Flight, Level 2 (L2), Burst Mode, 0.605 s Data

Energetic Particle Detector (EPD), Energetic Ion Spectrometer (EIS) Energy by Time of Flight, Level 2, Burst Survey, 0.605 s Data. The EIS provides ion composition measurements (protons versus oxygen ions) and angular distributions over the energy range from approximately 45 to 500 keV.

MMS 3 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Pulse Height by Time of Flight, Level 2 (L2), Survey Mode, 2.42 s Data

Energetic Particle Detector (EPD), Energetic Ion Spectrometer (EPD EIS) Pulse Height by Time of Flight, Level 2, Quick-Look Survey, 2.42 s Data. The EIS provides ion composition measurements (protons versus oxygen ions) and angular distributions over the energy range from approximately 45 to 500 keV.

MMS 2 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Energy by Time of Flight, Level 2 (L2), Survey Mode, 2.42 s Data

Energetic Particle Detector (EPD), Energetic Ion Spectrometer (EIS) Energy by Time of Flight, Level 2, Quick-Look Survey, 2.42 s Data. The EIS provides ion composition measurements (protons versus oxygen ions) and angular distributions over the energy range from approximately 45 to 500 keV.

MMS 3 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Energy by Time of Flight, Level 2 (L2), Burst Mode, 0.605 s Data

MMS 1 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Energy by Time of Flight, Level 2 (L2), Burst Mode, 0.605 s Data

MMS 2 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Pulse Height by Time of Flight, Level 2 (L2), Burst Mode, 0.605 s Data

Energetic Particle Detector (EPD), Energetic Ion Spectrometer (EIS) Pulse Height by Time of Flight, Level 2, Burst Survey, 0.605 s Data. The EIS provides ion composition measurements (protons versus oxygen ions) and angular distributions over the energy range from approximately 45 to 500 keV.

Flight Data For Tail 657

MMS 4 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Pulse Height by Time of Flight, Level 2 (L2), Survey Mode, 2.42 s Data

Flight Data For Tail 667

MMS 1 Energetic Particle Detector, Energetic Ion Spectrometer (EPD-EIS) Pulse Height by Time of Flight, Level 2 (L2), Survey Mode, 2.42 s Data

Flight Data For Tail 676

Flight Data For Tail 662