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361
datasets available to search
ShareScore release 0.9.0
Dataset results
361 results for “respiratory disease”
REspiratory diSEAse cohoRt Studies of CHinese Medicine for Pneumonia (RESEARCH-Pneumonia)
ClinicalTrials.gov study NCT06220019. IPD Sharing: NO. Countries: 0. Publications: 0.
Innovations in Respiratory Muscles Training in Patients With Chronic Obstructive Pulmonary Disease. (INNOTORIO)
ClinicalTrials.gov study NCT02935166. IPD Sharing: YES. Countries: 0. Publications: 0.
EPI-743 for Mitochondrial Respiratory Chain Diseases
ClinicalTrials.gov study NCT01370447. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard
ClinicalTrials.gov study NCT00515606. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Respiratory Biofeedback Added to Strengthening Training in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT07369973. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Application of Chemical Sensors for Diagnosis of Inflammatory Bowel Diseases and Irritable Bowel Syndrome by Respiratory Samples
ClinicalTrials.gov study NCT01242163. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expression data of induced sputum from Unbiased BIOmarkers in Prediction of REspiratory Disease outcomes (U-BIOPRED) Project
GEO Series GSE76262. Homo sapiens. 139 samples. Type: Expression profiling by array.
Regulatory KIR+RA+ T cells accumulate with age and are highly activated during viral respiratory disease
GEO Series GSE174779. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Olfactomedin 4 serves as a marker for disease severity in pediatric Respiratory Syncytial Virus (RSV) infection
GEO Series GSE69606. Homo sapiens. 43 samples. Type: Expression profiling by array.
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease (worm)
GEO Series GSE119696. Caenorhabditis elegans. 28 samples. Type: Expression profiling by high throughput sequencing.
Longitudinal blood transcriptomic analysis to identify molecular regulatory patterns of Bovine Respiratory Disease in beef cattle
GEO Series GSE150706. Bos taurus. 72 samples. Type: Expression profiling by high throughput sequencing.
Characterization of Risks and Pathogenesis of Respiratory Diseases Caused by Rural Atmospheric PM2.5
GEO Series GSE246730. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize NSAID-exacerbated respiratory disease
GEO Series GSE189690. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease (human)
GEO Series GSE119699. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article: Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson's Disease: Triggers for Respiratory Rehabilitation?
<p>Dataset related to the article:</p> <p>Vitacca, M.; Olivares, A.; Comini, L.; Vezzadini, G.; Langella, A.; Luisa, A.; Petrolati, A.; Frigo, G.; Paneroni, M. Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson’s Disease: Triggers for Respiratory Rehabilitation? <em>Int. J. Environ. Res. Public Health</em> <strong>2021</strong>, <em>18</em>, 12298.</p> <p>Abstract: The role that oxygen desaturation plays in exercise tolerance and its rehabilitative implications<br> in patients with Parkinson’s disease (PD) are unclear. We aimed to test exercise tolerance and<br> oxygen saturation levels both during exercise and at night in PD patients to better define their rehabilitative<br> needs. In clinically stable PD patients, undergoing inpatient rehabilitation, and in “ON” phase,<br> we prospectively assessed clinical data, sleepiness, comorbidities, PD severity (Hoehn&Yahr, HY),<br> motor function (ADLs, UPDRSII and UPDRSIII, Barthel Index, Functional Independence Measure),<br> balance, spirometry, respiratory muscles (MIP/MEP), peak cough expiratory flow (PCEF), continuous<br> night oxygen monitoring, and meters at 6MWT. Of 55 patients analyzed (28 with moderate–severe PD,<br> HY 2.5), 37% and 23% showed moderate–severe impairment on UPDRSII and UPDRSIII, respectively;<br> 96% had reduced exercise tolerance and severe respiratory muscles impairment (MIP/MEP<br> < 45% pred.); 21.8% showed desaturations during exercise; and 12.7% showed nocturnal desaturations.<br> At multiple regression, low exercise tolerance and low mean nocturnal and exercise-induced<br> saturation correlated with several respiratory and motor function and disability indices (all p <<br> 0.03). Exercise tolerance, exercise-induced desaturations, and nocturnal desaturations were extremely<br> frequent in PD patients and were worse in more severe PD patients. This suggests considering a<br> combined role for motor and respiratory rehabilitation in these patients.</p>
Dataset related to: Voice alterations, dysarthria and respiratory derangements in patients with Parkinson's disease
<p>Dataset related to the article:</p> <p>Di Pietro DA, Olivares A, Comini L, Vezzadini G, Luisa A, Petrolati A, Boccola S, Boccali E, Pasotti M, Danna L, Vitacca M. Voice Alterations, Dysarthria, and Respiratory Derangements in Patients With Parkinson's Disease. J Speech Lang Hear Res. 2022 17;65(10):3749-3757.</p> <p>Purpose: Almost 90% of people with Parkinson’s disease (PD) develop voice and speech disorders during the course of the disease. Ventilatory dysfunction is one of the main causes. We aimed to evaluate relationships between respiratory impairments and speech/voice changes in PD.<br> Method: At Day 15 from admission, in consecutive clinically stable PD patients in a neurorehabilitation unit, we collected clinical data as follows: comorbidities, PD severity, motor function and balance, respiratory function at rest (including muscle strength and cough ability), during exercise-induced desaturation and at night, voice function (Voice Handicap Index [VHI] and acoustic analysis [Praat]),<br> speech disorders (Robertson Dysarthria Profile [RDP]), and postural abnormalities. Based on an arbitrary RDP cutoff, two groups with different dysarthria degree were identified—moderate–severe versus no–mild dysarthria—and compared.<br> Results: Of 55 patients analyzed (median value Unified Parkinson’s Disease Rating Scale Part II 9 and Part III 17), we found significant impairments in inspiratory and expiratory muscle pressure (> 90%, both), exercise tolerance at 6-min walking distance (96%), nocturnal (12.7%) and exercise-induced (21.8%) desaturation, VHI (34%), and Praat Shimmer% (89%). Patients with moderate–severe dysarthria (16% of total sample) had more comorbidities/disabilities and worse respiratory pattern and postural abnormalities (camptocormia) than those with no–mild dysarthria. Moreover, the risk of presenting nocturnal desaturation,<br> reduced peak expiratory flow, and cough ability was about 11, 13, and 8 times higher in the moderate–severe group.<br> Conclusions: Dysarthria and respiratory dysfunction are closely associated in PD patients, particularly nocturnal desaturation and reduced cough ability. In addition, postural condition could be at the base of both respiratory and voice impairments.</p>
Identifying target genes involved in subclinical respiratory disease that develop in athletes: an insight from the horse athlete and the use of microarrays
GEO Series GSE22843. Equus caballus. 24 samples. Type: Expression profiling by array.
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease
GEO Series GSE119723. Caenorhabditis elegans; Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Precision Cut Lung Slices: A Novel Method for Examining Respiratory Diseases
GEO Series GSE41684. Mus musculus. 167 samples. Type: Expression profiling by array.
Polymorphism in exercise genes and respiratory function in late-onset Pompe disease
<p>This database includes the raw data linked with the paper “ Polymorphism in exercise genes and respiratory function in late-onset Pompe disease ” published on “JOURNAL OF APPLIED PHYSIOLOGY”. In this paper, we reported the influence of polymoprhisms in exercise genes and muscle metabolism, on the clinical phenotype of late onset pomep disease, especially on the respiratory phenotype</p> <p>We included 43 patients with LOPD (25 males, age 50.8 ± 13.6 yr) with a 2-yr follow-up since the beginning of enzyme replacement therapy (ERT). Twenty-two patients showed a postural drop >25% T0, seven other patients developed it during the follow-up. We analyzed the relationship between the progression of respiratory dysfunction and genetic polymorphisms affecting muscle function and structure [angiotensin converting enzyme (ACE), a-actinin 3 (ACTN3), peroxisome proliferator-activated receptor a (PPR-a), angiotensin (AGT)], glycogen metabolism [glycogen synthase (GYS), glycogen synthase kinase-3 isoform b (GSK3b)], and autophagy [sirtuin 1 (SIRT1), autophagy-related gene 7 (ATG7)].</p> <p>ACE-DD and ACTN3-XX polymorphisms, possibly influencing muscle properties and fiber composition, were associated with more severe respiratory phenotypes</p> <p> </p> <table align="left"> <tbody> <tr> <td> <p> </p> </td> </tr> </tbody> </table>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.