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1,154 results for “Pooling”
Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort
<p>Background: While numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk, few have assessed this association for concentrations >40 ng/ml.</p> <p> </p> <p>Objective: To investigate the relationship between 25(OH)D concentration and breast cancer risk across a broad range of 25(OH)D concentrations among women aged 55 years and older.</p> <p> </p> <p>Methods: Analyses used pooled data from two randomized clinical trials (N=1129, N=2196) and a prospective cohort (N=1713) to examine a broad range of 25(OH)D concentrations. The outcome was diagnosis of breast cancer during the observation periods (median: 4.0 years). Three analyses were conducted: 1) Incidence rates were compared according to 25(OH)D concentration from <20 to ≥60 ng/ml (<50 to ≥150 nmol/L), 2) Kaplan-Meier plots were developed and 3) multivariate Cox regression was used to examine the association between 25(OH)D and breast cancer risk using multiple 25(OH)D measurements.</p> <p> </p> <p>Results: Within the pooled cohort (N=5038), 77 women were diagnosed with breast cancer (age-adjusted incidence: 512 cases per 100,000 person-years). Results were similar for the three analyses. First, comparing incidence rates, there was an 82% lower incidence rate of breast cancer for women with 25(OH)D concentrations ≥60 vs <20 ng/ml (Rate Ratio=0.18, <em>P</em>=0.006). Second, Kaplan-Meier curves for concentrations of <20, 20-39, 40-59 and ≥60 ng/ml were significantly different (<em>P</em>=0.02), with the highest proportion breast cancer-free in the ≥60 ng/ml group (99.3%) and the lowest proportion breast cancer-free in the <20 ng/ml group (96.8%). The proportion with breast cancer was 78% lower for ≥60 vs <20 ng/ml (<em>P</em>=0.02). Third, multivariate Cox regression revealed that women with 25(OH)D concentrations ≥60 ng/ml had an 80% lower risk of breast cancer than women with concentrations <20 ng/ml (HR=0.20, <em>P</em>=0.03), adjusting for age, BMI, smoking status, calcium supplement intake, and study of origin.</p> <p> </p> <p>Conclusions: Higher 25(OH)D concentrations were associated with a dose-response decrease in breast cancer risk with concentrations ≥60 ng/ml being most protective.</p>
FIGURE 5 in Three new species of spinicaudatan clam shrimps from Australia, all from gnammas (rock pools)
FIGURE 5. Ozestheria pellucida sp. nov. Male. A, carapace. B, sculpturing between growth lines on the carapace. C, head and antennae. D, dorsum of trunk segments VI to XVIII. E, telson. F, clasper with an enlargement of the apex of the moveable finger. Scale bars 1 mm.
FIGURE 2 in Three new species of spinicaudatan clam shrimps from Australia, all from gnammas (rock pools)
FIGURE 2. Eulimnadia kimberleyensis sp. nov.. Female, A, carapace. B, head. C, second antenna dorsal flagellum. D, telson. Scale bars 1 mm.
FIGURE 1 in Three new species of spinicaudatan clam shrimps from Australia, all from gnammas (rock pools)
FIGURE 1. Scanning Electron Micrographs of Eggs. A, B,C, Eulimnadia kimberleyensis sp. nov.; D,E,F, Paralimnadia laharum sp. nov.
FIGURE 4 in Three new species of spinicaudatan clam shrimps from Australia, all from gnammas (rock pools)
FIGURE 4. Paralimnadia laharum sp. nov. Digital images of individuals in AM P101152. A, male whole animal. B, male head. C,male rostrum. D, male telson. E, male clasper 1. F, female whole animal. G, female head and rostrum. H, female telson. J, female posterior dorsum of trunk. Scales as shown for each image.
FIGURE 3 in Three new species of spinicaudatan clam shrimps from Australia, all from gnammas (rock pools)
FIGURE 3. Paralimnadia laharum sp. nov. Drawings of Holotype, Allotype and Paratypes NMV J73116-8. A, male carapace. B male telson. C, male head. D, male Ist clasper with large palp of 2nd clasper alongside. E, male second antenna dorsal flagellum. F, female carapace. G, female telson. H, female head. Scale bars 1 mm.
An evaluation of pool-sequencing transcriptome-based exon capture for population genomics of non-model species.
<p>This archive is associated with the article “An evaluation of pool-sequencing transcriptome-based exon capture for population genomics of non-model species.”. Authors: Emeline Deleury, Thomas Guillemaud, Aurelie Blin & Eric Lombaert.</p> <p>The archive contains :<br> - The sequences of the 5,717 Harmonia axyridis randomly selected CDS (5717-targeted-CDS-sequences.gff3, sequence in FASTA format at the end of the file)<br> - For the subset of 3,161 targeted CDS that have a genomic match over their entire length, the positions of exons on transcripts (3161-targeted-CDS-EXON-POSITIONS.csv)</p>
FIGURE 5 in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 5. Plots of effective size trends through time generated by Vareff. The x-axis represents time to the past expressed as the product of the generation time (T) by the mutation rate. The y-axis represents the effective size expressed as the log10 of theta, where theta = 4Neu. For abbreviations, see Fig. 1.
FIGURE 1 in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 1. Geographic location of the 15 naturally occurring vernal pools sampled in Baja California, México. The main map
FIGURE 7 in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 7. Phenotypic traits variation between sexes of B. sandiegonensis individuals in Baja California, México. Asterisks indicates significant differences between sexes at the P<0.0001 level.
FIGURE 6 in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 6. Phenotypic trait variation of B. sandiegonensis individuals across the four geographic regions sampled in Baja California. Data with different uppercase letters are significantly different at the P<0.05 level, according to Tukey post-hoc tests. For abbreviations, see Fig. 1.
FIGURE 3. a in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 3. a, Bayesian phylogenetic tree of B. sandiegonensis based on analysis of mitochondrial COI sequences, showing the two major clades: Clade A and Clade B (sensu Bohonak 2005). The 31 samples obtained in this study are denoted by rectangles, with colors corresponding to the region of collection. The 54 sequences downloaded from GenBank lack colored rectangles, and all are from the northern portion of the species' range in the USA (GenBank accession numbers: FJ439689-FJ439743). The tree was rooted with Branchinecta lynchi (GenBank accession numbers HM568501-HM568505). Numbers on branches indicate Bayesian posterior probabilities ≥0.8. b, Median-joining haplotype network based on 568 bp of the mitochondrial COI sequences. Circle size is proportional to haplotype frequencies; line length is roughly proportional to the estimated number of steps between haplotypes. Each geographic region is represented in a different color. For abbreviations, see Fig. 1.
FIGURE 2 in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 2. Definition of the six morphometric traits measured on 232 individuals of B. sandiegonensis. Drawing modified from Fugate (1993) and morphometric features based on Timms (2012). a, total body length. b, thorax length. c, abdomen length. d, cercopod length. e, antennule length. f, right antenna length for males, and f1 for females.
FIGURE 4. a in Genetic and phenotypic diversity of Branchinecta sandiegonensis (Crustacea: Anostraca) in the vernal pools of Baja California, México
FIGURE 4. a, Principal components analysis of the individual genotypes, where the region was used as class factor for the analysis. Colors correspond to the region. b, Edwards genetic distance Dendrogram. The colors below names correspond to the region. c, plots of the genetic clusters inferred by STRUCTURE (K=2, 3, 4). Each vertical column represented an individual, and pools are indicated by the legend. For abbreviations, see Fig. 1.
Figure 2 in Macroinvertebrate and vertebrate fauna of temporary pools, Hudson River Valley, New York, USA
Figure 2. Ternary diagram of the major cation composition of pool water expressed as the percentage of the total cations (in milliequivalents per litre). Calcium is the dominant cation type for most of the pools, reflecting local geology. Sodium is the dominant cation in Pools 15 and 20, both bordering public roads.
Figure 1 in Macroinvertebrate and vertebrate fauna of temporary pools, Hudson River Valley, New York, USA
Figure 1. Northern Dutchess and Ulster counties, Hudson Valley, New York, USA. Locations of temporary pools sampled in this study are indicated by black circles.
Figure 3 in Macroinvertebrate and vertebrate fauna of temporary pools, Hudson River Valley, New York, USA
Figure 3. Random forest regression plot of the relative importance of environmental variables (predictors) on total taxon richness. Direction (positive or negative) of the relationships is indicated by the + or – sign on the x-axis; direction is not strongly indicated for all the weaker predictors.
Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase
<p>This dataset contains the raw read counts from the CRISPRi-Seq experiments.</p>
Peptide Pool Instability of Precancerous Lesion in Rats with Model of Chronic Pancreatitis and/or Without Type 1 Diabetes Mellitus
<p><span><strong>Supplementary table 1. </strong>Data of Shapiro-Wilk (W) normality test and Homogeneity of Variance Test (Levene's F Test).</span></p> <p> </p> <p><span><strong>Supplementary table 2. </strong>Kruskal-Wallis as the overall test (H-values) and posthoc Dunn's test with Bonferroni correction. The corrected α using the Bonferroni correction method is 0.017</span></p>
FIGURE 3 in Phylogenetic relationships among the Iranian Triticum diploid gene pool as inferred from the loci Acc1 and Pgk1
FIGURE 3. Comparison of partial sequences of Pgk1 gene from the Iranian wild diploid Triticum (haplotypes 1−3) and related species. Indels 1 and 2 occurred at positions 54−59 and 475−476, respectively. Indel 3 was found at positions 509−517. Indel 4 was occurred at positions 558−565. The positions of 29 nucleotide substitutions are indicated.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.