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Dataset results
921 results for “corticosteroid”
Eosinophil-guided Reduction of Inhaled Corticosteroids
ClinicalTrials.gov study NCT04481555. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Corticosteroid Therapy of Septic Shock - Corticus
ClinicalTrials.gov study NCT00147004. IPD Sharing: Not stated. Countries: 9. Publications: 3.
Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury
ClinicalTrials.gov study NCT01093261. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Differential Efficacy of Corticosteroid Solutions for Non-Operative Treatment of Digit Flexor Tenosynovitis
ClinicalTrials.gov study NCT04002037. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review
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Data from: Harsh conditions during early development influence telomere length in an altricial passerine: links with oxidative stress and corticosteroids
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Sex-specific maternal programming of corticosteroid binding globulin by predator odour
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Systemic corticosteroids and mortality in severe and critical COVID-19 patients in Wuhan, China
<p><strong>Background:</strong> Systemic corticosteroids are now recommended in many treatment guidelines, though supporting evidence is limited to one randomised controlled clinical trial (RECOVERY). </p> <p><strong>Objective:</strong> To identify whether corticosteroids were beneficial to COVID-19 patients. </p> <p><strong>Methods:</strong> 1514 severe and 249 critical hospitalized COVID-19 patients from two medical centers in Wuhan, China. Multivariable Cox models, Cox model with time-varying exposure and propensity score analysis (inverse-probability-of-treatment-weighting (IPTW) and propensity score matching (PSM)) to estimate the association of corticosteroid use with risk of in-hospital mortality in severe and critical cases.</p> <p><strong>Results:</strong> Corticosteroids were administered in 531 (35.1%) severe and 159 (63.9%) critical patients. Compared to non-corticosteroid group, systemic corticosteroid use was not associated with beneficial effect in reducing in-hospital mortality in both severe cases (HR=1.77, 95% CI: 1.08-2.89, p=0.023), and critical cases (HR=2.07, 95% CI: 1.08-3.98, p=0.028). Findings were similar in time-varying Cox analysis. For severe COVID-19 patients at admission, corticosteroid use was not associated with improved or harmful outcome in either PSM or IPTW analysis. For critical COVID-19 patients at admission, results were consistent with multivariable Cox model analysis.</p> <p><strong>Conclusion:</strong> Corticosteroid use was not associated with beneficial effect in reducing in-hospital mortality for severe or critical cases in Wuhan. Absence of the beneficial effect in our study in contrast to that was observed in the RECOVERY clinical trial may be due to biases in observational data, in particular prescription by indication bias, differences in clinical characteristics of patients, choice of corticosteroid used, timing of initiation of treatment and duration of treatment. <br> </p>
Data from: Corticosteroid-binding globulin deficiency independently predicts mortality in septic shock
<p>Context Hydrocortisone administration in septic shock remains controversial. Corticosteroid-binding globulin (CBG) transports cortisol to inflammatory sites and is depleted in septic shock. Objective To determine if severely deficient serum CBG <200 nmol/L (Ref range 269-641 nmol/L) independently predicts septic shock mortality. Methods A prospective observational study in patients with septic shock. Patients were categorised into two groups: mean plasma CBG concentrations <200 nmol/L and ≥200 nmol/L (day 1/2), with additional categorisation by nadir CBG. Primary outcome was ICU mortality. Secondary outcomes were 28- and 90-day mortality, norepinephrine requirements, renal-replacement therapy, and clinician-instituted hydrocortisone. Results 135 patients were included. Mortality rates in ICU were higher in the CBG <200 nmol/L vs the CBG ≥200 nmol/L group: 32.4% vs 13.9%; Odds ratio (OR), 2.97, (95% confidence intervals (CI) 1.19,7.41); P=0.02: 28-days; OR 2.25 (95% CI 0.99,5.11): 90-days; OR 2.21 (95% CI 0.99,4.91). Multivariate analysis revealed 4 factors independently associated with ICU mortality: CBG <200 nmol/L (OR 3.23, 95% CI 1.06,9.88), Acute Physiology and Chronic Health Evaluation II >25 (OR 3.58, 95% CI 1.20,10.68); SOFA liver score (OR 1.98, 95% CI 1.04,3.72); and renal-replacement therapy (OR 6.59, 95% CI 2.17,20.01). Nadir CBG levels were associated with higher SOFA cardiovascular scores, norepinephrine total dose (ug) P<0.01 and duration (days) P<0.01. Plasma cortisol concentrations and hydrocortisone administration did not relate to ICU mortality. Conclusion Septic shock patients with CBG <200 nmol/L had higher norepinephrine requirements and 3.2-fold higher ICU mortality. CBG concentration was the only directly reversible independent mortality risk factor.</p>
Supplementary material 1 from: Kadushkin AG, Tahanovich AD, Movchan LV, Dziadzichkina VV, Levandovskaya OV, Shman TV (2022) Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease. Research Results in Pharmacology 8(1): 59-70. https://doi.org/10.3897/rrpharmacology.8.75467
Table S1
Risk of bias assessment for Corticosteroids for leptospirosis treatment
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A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
ClinicalTrials.gov study NCT06143891. IPD Sharing: YES. Countries: 24. Publications: 0.
Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone
ClinicalTrials.gov study NCT03704584. IPD Sharing: NO. Countries: 1. Publications: 0.
Using Tests in Preschool Children With Wheeze to Determine the Need for Inhaled Corticosteroid Therapy.
ClinicalTrials.gov study NCT04942483. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Corticosteroid Dosage for Crohn's Disease Flare
ClinicalTrials.gov study NCT02392286. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Oral AB1010 in Adult Patients With Severe Persistent Corticosteroid Dependent Asthma
ClinicalTrials.gov study NCT00842270. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Subacromial Injection With Corticosteroid Versus Nonsteroidal Anti-inflammatory Drugs (NSAID) in Shoulder Impingement Syndrome
ClinicalTrials.gov study NCT01449448. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study of Gecacitinib-corticosteroid as First-line Therapy for Grade II-IV Acute Graft Versus Host Disease
ClinicalTrials.gov study NCT07185633. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Bepotastine Besilate-corticosteroid Nasal Spray Combination Compared to Placebo, Bepotastine Besilate Nasal Spray, and Corticosteroid Nasal Spray in the Treatment of Patients With Seasonal Allergic Rh
ClinicalTrials.gov study NCT01578278. IPD Sharing: Not stated. Countries: 1. Publications: 0.
BI 671800 in Asthmatic Patients on Inhaled Corticosteroids
ClinicalTrials.gov study NCT01103349. IPD Sharing: Not stated. Countries: 9. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.